ID A0A3B3DHH7_ORYME Unreviewed; 1090 AA.
AC A0A3B3DHH7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=MLLT10 histone lysine methyltransferase DOT1L cofactor {ECO:0000313|Ensembl:ENSOMEP00000029558.1};
GN Name=MLLT10 {ECO:0000313|Ensembl:ENSOMEP00000029558.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000029558.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000029558.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3DHH7; -.
DR STRING; 30732.ENSOMEP00000029558; -.
DR PaxDb; 30732-ENSOMEP00000029558; -.
DR Ensembl; ENSOMET00000032511.1; ENSOMEP00000029558.1; ENSOMEG00000013297.1.
DR GeneTree; ENSGT00940000157711; -.
DR OMA; XFSELLN; -.
DR OrthoDB; 163389at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0060729; P:intestinal epithelial structure maintenance; IEA:Ensembl.
DR CDD; cd20901; CC_AF10; 1.
DR CDD; cd15708; ePHD_AF10; 1.
DR CDD; cd15574; PHD_AF10_AF17; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR049773; AF10-like_CC.
DR InterPro; IPR049781; AF10/AF17_PHD.
DR InterPro; IPR049775; AF10_ePHD.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR PANTHER; PTHR13793:SF93; PROTEIN AF-10; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 23..75
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 80..199
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 135..198
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 203..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1064..1090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 793..827
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 209..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1090 AA; 112065 MW; 50E1E800E5C0B31B CRC64;
MVAGERCLTV HDKLSTSNMK EMIGGCCVCS DERGWAENPL VYCDGHGCNV AVHQACYGIV
QVPTGPWFCR KCESQERAAR VRCELCPHKD GALKRTDNGG WAHVVCALYI PEVEFANVST
MEPIVLQSVP HERYNKTCYI CEEQGRESKA ATGACMTCNK HGCRQAFHVT CAQFAGLLCE
EQGNDADNVK YCGYCKYHHS KLRRSRGRGS RSQSLSDSSS QSMARPPDLD KKKHKERDRH
KPKHKKSAMD MSPSLVLPNI MGPEKPYNSG SSGGAVNSLP ASSQKRLDDN AARFTNANFQ
EVSSSHSGSN SNSKDGLAAD PGKSASEVKN KKNSGAGHAV GSRVGRKSLT SSGKPLPSTV
VTMATSSTSV SASTGPFHQG LLLTSASKTP SAPSTDFISF TDSSLRPGSG TTFSSPPSFS
SCLVKPSSEG GASEGTTTLF GSLMSPSTAS AVGGKLYENS HSHTTGETPS LVGSTGYKRP
QPSSAGLGIG GAPTAGTEDG VKKKKKGNWR NRFGPCFTTD VKPTEPAPSL TLPTSSSASA
SSSTASIAVS ACSTLSGRPG LVSSSGLGVG MGGGAERGLG VMGVGAGIQK SPSLLRNGSL
QSNSSSTSTV SGVFSGDGSS SGSGVVAMGG ASSELSQQPQ PTPSLAPPSP FTATAPLNST
ASTHVSGLPG SVFNLAPPHM FGNRLNPNSS MAALIAQSEA TPADQEVGDG SGGSQGFPVR
ASPKTTPRSP IGGLQIRYDS LGSLPGPGLG LLGSGGGVGE TLPPVATSIE QLLERQWNEG
QSFLLQQGAQ GDVVGMLKSL HQLQEENRRL EEQIKTLTMK KERLQLLSAQ LSVPFTPSTA
CSEVRGTQAG VSDSSLPVAA QDTASCGGHS SNGSTSSLST PPSVSQSPPQ PALNGVATTA
GLSGVTGLIG ALGAGNVLGI GGIVGALNGV IQTPAGTASP HTHTTGAAAG VTLPVNSSSS
ATSKNSTTRL GLLSEQQRLL LQQQQLQQLL ASQPSGDQQQ VLLYQLMQQQ QDLQQLQSLS
SSAQIPSISL SSAQIPINNL LPGTPSQGQG AITANPFLAL QHAHTDTHGS GAQKPRLAEK
AVGVAGQEKT
//
