ID A0A3B3DI93_ORYME Unreviewed; 431 AA.
AC A0A3B3DI93;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Iroquois homeobox 1 {ECO:0000313|Ensembl:ENSOMEP00000029621.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000029621.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000029621.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/IRO homeobox family.
CC {ECO:0000256|ARBA:ARBA00008446}.
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DR AlphaFoldDB; A0A3B3DI93; -.
DR STRING; 30732.ENSOMEP00000029621; -.
DR PaxDb; 30732-ENSOMEP00000029621; -.
DR Ensembl; ENSOMET00000019281.1; ENSOMEP00000029621.1; ENSOMEG00000013396.1.
DR GeneTree; ENSGT00940000160429; -.
DR OMA; ITDRPHH; -.
DR OrthoDB; 2915644at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR003893; Iroquois_homeo.
DR PANTHER; PTHR11211; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX; 1.
DR PANTHER; PTHR11211:SF13; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-1; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00548; IRO; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 119..172
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 121..173
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 185..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..206
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 431 AA; 45807 MW; 756469CEC962C5D0 CRC64;
MSFPQLGYPQ FLGASHDLYG SERPASAREA ATEGGAGSSA AAAAVGSVLG VYGSPWAQNY
SAFLPYSGAA DLALLSQMSS QYELKEPGSH AALPVHAAQS FYPYGQYPYG DPSRAKTATR
ETTSTLKAWL QEHQKNPYPT KGEKIMLAII TRMTLTQVST WFANARRRLK KENKVTWGRS
AEDRDGRIFS SDNEDEHEHG KNGSDGEDEE EIDLETVDIE QSSEAGLPVE ERASESNRTL
SAEAAAPLPP AVKLPAGHSP SAQECQRPPQ SKPKIWSLAE TATTPDSSHK PSAAALAHHA
ALASPGHPAL LPAHGIYTCQ IGKLHNWANT ALLNANSILN MRSLLGGAPG GHLSLQGAVP
AARHDARPAA AAAGNSGTED ESDAESTGSF SPKRDDEESD HGPEPLKSPF QLITDRSHHG
TASQRVLTTT L
//
