ID A0A3B3DIV4_ORYME Unreviewed; 1254 AA.
AC A0A3B3DIV4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Ras/Rap GTPase-activating protein SynGAP-like {ECO:0000313|Ensembl:ENSOMEP00000030038.1};
GN Name=SYNGAP1 {ECO:0000313|Ensembl:ENSOMEP00000030038.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000030038.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000030038.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3DIV4; -.
DR Ensembl; ENSOMET00000020067.1; ENSOMEP00000030038.1; ENSOMEG00000014068.1.
DR GeneTree; ENSGT00940000158438; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR CDD; cd22265; UDM1_RNF168; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR PANTHER; PTHR10194:SF145; RAS_RAP GTPASE-ACTIVATING PROTEIN SYNGAP ISOFORM X1; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT DOMAIN 151..185
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 176..294
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 361..553
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 29..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 818..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 967..1116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1235..1254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1155..1221
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 837..852
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..889
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..1065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1254 AA; 140762 MW; E0BAAEEBAFFC3C27 CRC64;
MDTSSKSWLP HQSQFGLVGQ AEACCGGSGV LTPNQSRRAS FASVRQSSME TPPNTTPQPF
RQPSFLNRRL KGSIKRAKSQ PKLDRTSSFR QMILPRFRSA DQERTRLMQS FKESHSHESL
LSPSSAAEAL DLVLDEDAII KPVHSSILGQ EYCFEVTTNS GTKCFACRSA SERDKWIENL
QRAVKPNKDN SRRVDNVLKL WIIEARDLPA KKRYYCELCL DDMLYARTTS KPRTDTVFWG
EHFEFNNLPT IRSLRLHLYK ETDKKRRKEK STYIGLVSIP ISSITGRQFV EQWYPVIQSS
VLAKGGGVGS TKVINASLRI KSRYQTMNIL PMELYKEFAE YITNNYRTLC AVLEPLLSVK
SKEEVAFALV HILQSTGKTK EFLSDMAMCE VDRFMDREHL IFRENTLATK AVEEYLKLIG
HRYLKEAIGD FIRALYESEE NCEVDPMRVP PSVLADHQAN LRMCCELLLC KIINSLCIFP
RELKEVFASW RARSAERGRE DLADSLISSS LFLRFMCPAI MSPSLFSLMQ EYPAERTSRT
LTLIARVMQN LASFSKFGPK EEYMYFMNEF LEMEWGSMQQ FLYEISNLDT GGNAGGFEGY
IDLGRELSML HSLLWEVMGQ LSKDAILKLG PLPRLLNDIS VALRNPQLHM PTNQQPERPK
DRLFTRPSFN RLMSSDFQSL MMRDLNSSID ISRLPSPTTG LSAVESLSSN LNMRRQAERD
FRSSREVFYV TRPPLARSSP AYCTSSSDIT EPDPKVKGGH YVHSVNKSVS MMDLQDSRMN
SISNLNSVGD MLASSQASIA GLGHSFGNLG GPLRVGGHLP PGSSGSGLRL SQMGHVGGPT
ESISQQQQQA AAAMHFPLSF QNPLFHLAAQ NSPAQSQPPA PPPPLLLAPE HENGHPDYPP
AFGNSAFSRS EDLSALRSQS SLVQPSIVHS HSYSDDFTRQ NQSNDFAWHQ LSLQVQESLQ
QQHLMGVTSH TGTGTGTPAS LATPPTTVHP VRQTSIAPHL KSQRSINTPA TATPPKVRPQ
SRNILLDASD TNMSGSQPKS RPSQQAAQQQ MPQQDAQTVT DSPAPGLPFQ TGAAKENQAP
AAAAEESTDT PTKSGKKSQL QPPQQHLLKP VANKQGNMNE RTVAWVSNMP HLSADIESLR
PDREGQLKEY SKSMDESRLE RVREYEEEIH NLKERLKMSH RKLEEYEQRL VSQEQQTSKI
LQQYQNRLED SERRLKQQQL EKDSQIKGII HSLSARAMGA SQDPDYQLQS DQSS
//
