ID A0A3B3DIW6_ORYME Unreviewed; 609 AA.
AC A0A3B3DIW6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000029424.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000029424.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
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DR AlphaFoldDB; A0A3B3DIW6; -.
DR STRING; 30732.ENSOMEP00000029424; -.
DR PaxDb; 30732-ENSOMEP00000029424; -.
DR Ensembl; ENSOMET00000018892.1; ENSOMEP00000029424.1; ENSOMEG00000013073.1.
DR GeneTree; ENSGT01100000263560; -.
DR OMA; NACEERV; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd05481; retropepsin_like_LTR_1; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 3.10.20.370; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001995; Peptidase_A2_cat.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR PANTHER; PTHR37984:SF10; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF13650; Asp_protease_2; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50175; ASP_PROT_RETROV; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT DOMAIN 24..63
FT /note="Peptidase A2"
FT /evidence="ECO:0000259|PROSITE:PS50175"
SQ SEQUENCE 609 AA; 67922 MW; E656AEE27B9D7DDB CRC64;
MVCSNDSDMD DSWKETVTIK GVPVTFKLDT GADANVLPKS VYTKLPGAPQ LQPTKTVLVA
FGGTRIHPDG VVSLECKTRK CKGVCDFLVS SYADKSILGG QACEELQLVK RVGTIGTTKS
PQPTKPPATK EELIEKYAEV FTGLGEFPGV HHIHTDPNVT PVIHACRNVP LSILEPLKKT
LKDLQDRNVI TPVNEPTDWV NSLVATQKKN GTLRVCLDPC DLNQAVKRQH YSIPTHEDVR
SKLAGKSVFT ILDERDGYWQ IELNEPSSKL CTFNTPWGRY RFLRLPFGIK SASEVFQPKN
CETFGNIPGV FIIADDMIIA ATSEREHDEI LQKVMERAKT ANVKFNKDKI QFKVNTVKYL
GHIITASGQK ADNAKIRAII DMPTPDDKQS LQHQLGMTKF LAQYIQNEAS LTAPLRQLLK
KDTVWQWQPH HTAVLSTLKT ALTRAPVLRF YDHKRPLTLQ ADSSKDGLGA CLLQEGQPVC
YASRALTDTE KRYAQIEKEL LAIVFTTKRF HQYVYGRPVT VQSDHKPLEA IMRKPLSKAP
ARLQGMLLQL QRYELTVTYT PGKDMFIADA LSRATATSDN DTASENACEE RVVYALEATE
ALVKTCSTD
//