ID   A0A3B3DK87_ORYME        Unreviewed;      1295 AA.
AC   A0A3B3DK87;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=TBC1 domain family, member 4 {ECO:0000313|Ensembl:ENSOMEP00000029889.1};
GN   Name=TBC1D4 {ECO:0000313|Ensembl:ENSOMEP00000029889.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000029889.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000029889.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   STRING; 30732.ENSOMEP00000029889; -.
DR   PaxDb; 30732-ENSOMEP00000029889; -.
DR   Ensembl; ENSOMET00000019851.1; ENSOMEP00000029889.1; ENSOMEG00000013864.1.
DR   GeneTree; ENSGT00940000158486; -.
DR   OMA; QQMRDPA; -.
DR   Proteomes; UP000261560; Unplaced.
DR   CDD; cd00934; PTB; 1.
DR   CDD; cd01269; PTB_TBC1D1_like; 1.
DR   Gene3D; 1.10.10.2750; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR   Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR   InterPro; IPR021785; DUF3350.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR000195; Rab-GAP-TBC_dom.
DR   InterPro; IPR035969; Rab-GAP_TBC_sf.
DR   PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR   PANTHER; PTHR47219:SF13; TBC1 DOMAIN FAMILY MEMBER 4 ISOFORM X1; 1.
DR   Pfam; PF11830; DUF3350; 1.
DR   Pfam; PF00640; PID; 1.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00462; PTB; 2.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   DOMAIN          916..1110
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000259|PROSITE:PS50086"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          333..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          610..706
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          731..761
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1276..1295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1190..1266
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        659..706
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        731..755
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1295 AA;  145578 MW;  A7E3F7B78DE31372 CRC64;
     MRMTDRCGCP HAKLTTPPNA QPRAPEPVKE NPCCCQTSFR LQVCLADMEI RDETAGKSFA
     LTYVGWCTLD RRTTLPMLPW LVAEIRRRSE KGGFGPVMQP REVQLLLHSP FIRCVPTSSS
     SSSVFIFEHK AQLVARFIHN SNDLSYFAYL LRGQPDNPES EMSCHVFKAS DPNQVPEVIS
     SIRQVSKSAL KEDAKPKQET EEAFYNSQKF EVLYCGKVTV GHKKAPISLI DDCIDKFRQH
     ETERKRLRLL NGQRGSTESA PVDFLMGEEG DPLSSVLNKN TEESDAPGME DISAGKGLSI
     SSSQSSLRGA FPECILEDSG FEEPQEFRTR CSSLAGSLQR KPGEAGIMGP TRRRHASAPN
     NVQPSDSDKN RTMLFQVGRF EVNLISPDSK TVVLEKNFKD ISSCCQGIKQ TDHFGFICRD
     PLDSGPSQYV CYVFQCASES LVDEVMLTLK QAFSTAAALQ SNKTQIQLCE ACPMHGLHKL
     CERIEGLYPP RAKLAIQQYL SELTDNEQAE VFEKVQKQKP GSDQEENELV ILYLRQICEA
     KQKSHLHIGE SPQNAGNSSA AGDGTAQSSR FKLDIFKSKA RTSLTSSLEN IFARGASRMR
     DRLGSMGSIS SFEKQDEESP GESPPGSPPA FPDNDLESGM QFRRRAHTFS HPPLRKRISF
     ESQLSNPSKQ APLRRQQSVN SELLQSSPAA VPRTRSVSES ESTFGLPSSF SAPTFLKSFY
     QGSLGSLSSL ADSGSLKSNG EGRKRSLSGC SSELVSAGLP PTPRRVSWRQ KIFLRVASPM
     NKPSASMQHT DDSPAGDLLP LSPHALDSSL DHLRRLLPMA HDQSPEGKPK KTGADYRALW
     KTAIHQQILL LRMEKENQRL EASRDELHIR KMKLDYQEVS QCSKETQAMW EKKLTAPGRT
     TNPQDKEDIY RAICQGVPKS RRGDVWLLLS HQHRLQHRLP QRQHAPDTPY HDLLKQLTAQ
     QHAILVDLGR TFPTHQYFSA QLGAGQLSLY NLLKAYSLLD TEVGYCQGIS FVAGVLLLHM
     SEDQAFDMLK FLMYDLGIRR QYRPDMVSLQ IQMYQLSRLL HDYHRDLYSH FEEHEICPSL
     YAAPWFLTLF ASQFPLGFVS RIFDFVFVQG TEVIFKVALC LLSSHEKEII ECDSFESIVD
     FLKTALPTLT EAQMEQTIAK VIEMDISKQL HAYEVEYHVL QDEMLDAGPL PDDSERLDKL
     EKTNTQLKKQ NMDLLEKLQA ARQKIQTLET SVESFLSRES KMKHMIRSLE QERAAHQRTI
     ERMRSCLPPD ALTDVEMTQI KTGPNGKAKT AAKKP
//