ID A0A3B3DLB4_ORYME Unreviewed; 1448 AA.
AC A0A3B3DLB4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=GTPase activating protein and VPS9 domains 1 {ECO:0000313|Ensembl:ENSOMEP00000030165.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000030165.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000030165.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GAPVD1 family.
CC {ECO:0000256|ARBA:ARBA00008489}.
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DR Ensembl; ENSOMET00000020272.1; ENSOMEP00000030165.1; ENSOMEG00000014358.1.
DR GeneTree; ENSGT00940000156611; -.
DR OMA; ENHEIML; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd05129; RasGAP_RAP6; 1.
DR Gene3D; 1.10.246.120; -; 1.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR041545; DUF5601.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR23101:SF25; GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR Pfam; PF18151; DUF5601; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF02204; VPS9; 1.
DR SMART; SM00167; VPS9; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 3: Inferred from homology;
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00023136}.
FT DOMAIN 144..352
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1308..1448
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REGION 446..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 986..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..771
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 935..954
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1006
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1448 AA; 161132 MW; 3E86AE40A7417269 CRC64;
MVKPDIHTLA HHLKQERLYV TSEKQLIQRL NSDVLKTAER LYRAAWIAKQ QRINLDRLIL
TSAEASPAEC CQHAKMLEDT QFVDGYKTLG FQETIYGEFL ARLRENPRLV ASCLVAGERL
NQEPTQGVIH TVFTSLYGNC IMQEDESYLL QVLRYLIEFE LKESDNPRRL LRRGTCAFSI
LFKLFSEGLY SAKLFLTATL HEPIMQLLVE DEDHLETDPA KVVEGLTPAQ RERFGEKGSE
GYKQRVQAAV EANEAKLVAL VNKFIGYLKQ NTYCFPHSLR WIVSQMYKTL SCVERLEVGE
VRTMCTDLLL TCFICPAIVN PEQYGIISDA PINEVARFNL MQVGQLLQKL AMADDDADPR
RKSTLSKFDK SCVAAFLDVV IGGRAVETPP MSAMNLLEGL SRTAVYITHN QLLALVDFVR
VVIGGDHLRE EEQMALETML ANVPQSRATK SNSLELTPSN TPQLSPATTP ANKKNRLPIA
GARSRSRTNI AQEGEAEASS QESIQELMPE EVLVISLGSG PLTVPGMMSE NEVLNMQMAY
GTQVDGHADE AKLHGKPDKT LRFSLCSDNL EGISEGPSNR SNSVSSLDPE VESISDSGAG
PSGSNGVEAL QLLEHEQATT QDNLDDKLRK FEIRDMMGLT DDRDISETVS ETWSTDVLGS
DFDPNMDEDR LQEIPAAENM LGSLLCLPGS GSVLLDPYGS TISETTSEAW SVEVLPSDSE
APDLKQEERL QELESCSGVG STSDDTEVRE VSSRPSTPGL SVVSGISATS EDIPNKIEDL
RSECSSDFGG KDSVTSPDGE ESSHGGHNLT SPPSQPDSLL AMFDPLSTGE GSSTGTIVRP
KVHYVRPPHP PPDPPIPEAS AVAPEIRHSL LGELELIKQR HSFPDRLVRS RSSDIVCPGR
RPTSDPGLNR RVAVEEREPG GAFALGPSSS PSKDSLKGEV EDRKDSDDEK SDRNRPWWKK
RFVSAIPKVL YWTAESDAPA PMAAFRKRDK QEKDDVGQER VLPDEPLHRQ ITQPQAAEDI
LDKYRNIKRT SPSDGTTAGA SYDGSGDICV EDGDCHREDG LQNIPADDLL DSASQTAQQH
DSKFSFSDAK KKLRLALCSA DSVALPIMAP ATTRNGLPDH MDPEDNEIVC FLKIQLAEAI
NLQDKNQMAQ IQETTRCVGR FDPRTCRKLL AAIAEDYRKR APYIAYLTRC RQGLQTSQAH
LERLLQRVLR DKEVANLYFT TVCVRLLLEH MESKMLDFIK AFQGCTAADD KTAAVEDFLR
YLYGAMARDA IWQYASEDQL QDAQMAIERS VMNRIFKLAF YPNQDGDILR DQLFHEHIQR
LTKVVTANHK ALQIPEVYLR EAPWPSAQAE IRSINAYKTP RDKVQCILRM CSTIMNLLSL
ANEDSVPGAD DFVPVLVFVL IRANPPCLLS TVQYINNFYA SRLSGEECYW WMQFTAAVEF
IKTIDDRK
//
