ID   A0A3B3DME0_ORYME        Unreviewed;       915 AA.
AC   A0A3B3DME0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=IQ motif and Sec7 domain ArfGEF 2a {ECO:0000313|Ensembl:ENSOMEP00000031086.1};
GN   Name=IQSEC2 {ECO:0000313|Ensembl:ENSOMEP00000031086.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000031086.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000031086.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the BRAG family.
CC       {ECO:0000256|ARBA:ARBA00006248}.
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DR   AlphaFoldDB; A0A3B3DME0; -.
DR   STRING; 30732.ENSOMEP00000031086; -.
DR   PaxDb; 30732-ENSOMEP00000031086; -.
DR   Ensembl; ENSOMET00000022036.1; ENSOMEP00000031086.1; ENSOMEG00000015738.1.
DR   GeneTree; ENSGT00940000159667; -.
DR   OMA; MSVSHRV; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd13318; PH_IQSEC; 1.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.220.20; -; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR033742; IQSEC_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR10663:SF314; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF16453; IQ_SEC7_PH; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50096; IQ; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   3: Inferred from homology;
FT   DOMAIN          454..646
FT                   /note="SEC7"
FT                   /evidence="ECO:0000259|PROSITE:PS50190"
FT   REGION          195..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          247..450
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..209
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        337..362
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        363..379
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        397..429
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   915 AA;  101829 MW;  05FE62354AFDE560 CRC64;
     ETLTFSDSSF GHPPPFHRYS NNPLPSLCDP YSPASTGRPL GTSYPASLAL RKQEEEESKR
     CKALSDSYEL STDLQDKKVE MLERKYGGQF VSRRAARTIQ TAFRRYRMKK NFERLRSSAS
     ESRMTRRIIL SNMRMQVCVK YPFFYSPTKL RRGLPCLSTS CDKCILGSAL QTVSASLLRT
     SVSLQVKSLA DSMDDSLTCQ NTNTSSRRPA GRAEGIRGGG AAMHEDSTAT SFSDVTLYMD
     DGCLPSSPLS RPASSSDTDY WGGGGAGGRE DSRETEGGSN ASRRSSTPCT ECRGEYRVRA
     AGGGGGHLPV LTIEPPSDSS VDMSDRSVGG CHLQSPPSSP LPSPVPPLTP LSPLPPPLTP
     SPLSSSSSSV LQNMEAQQQH LAHHPHLHHH HLLCSDGDNE SVNSTTTNSN DDTTVNNCSS
     GSSSRDSLRE PVGGATLGKQ TYQRESRHSW DSPAFNNDVV QRRQYRIGLN LFNKKPEKGI
     QYLIERGFVS DTPVGIARFI LERKGLSRQM IGEFLGSRQQ FNKDVLNCVL DEMDFSGMDL
     DDALRKFQAQ IKVQGEAQRV ERLVEAFSQR YCICNPVLIR QFQNPDTIFI LAFAIILLNT
     DMYSPNVKPE RKMKLEDFIK NLRGVDNGQD IPRDLLVAIY GRIQKWELRT NDDHVSQVQA
     VERMVVGKKP RRVFVCLLQV LSLPHRRLVC CCQLFEVPDP NRAQRSGVHQ REVFLFNDLL
     MVTKIFQKKK TSVTYSFRQS FPLLDMQVHT FQNSYYPHGI KLTSANPGGE RKVLIIFTAP
     SQQDRARFTS DLRESIAEVQ EMEKYRVESE LEKQKGVMRP AGSGGGPMKG EVVNGTLGRP
     SLDDTYASVD GLKRTALSSS LRDLSETGKR GRRNSVGSLD STIEVSWSVH EARCACCMFP
     CMFQQNLKSL ISPVY
//