ID A0A3B3DN82_ORYME Unreviewed; 979 AA.
AC A0A3B3DN82;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Toll-like receptor 13 {ECO:0000313|Ensembl:ENSOMEP00000031396.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000031396.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000031396.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR AlphaFoldDB; A0A3B3DN82; -.
DR STRING; 30732.ENSOMEP00000031396; -.
DR PaxDb; 30732-ENSOMEP00000031396; -.
DR Ensembl; ENSOMET00000033667.1; ENSOMEP00000031396.1; ENSOMEG00000016214.1.
DR GeneTree; ENSGT00940000163576; -.
DR OMA; TLDNCCV; -.
DR OrthoDB; 1207361at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0019731; P:antibacterial humoral response; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF522; TOLL-LIKE RECEPTOR 12; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 14.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 6.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..979
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017190755"
FT TRANSMEM 741..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 792..939
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 950..979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 979 AA; 112663 MW; 755A1955B9572CC2 CRC64;
MAFLTRKLLA LTVVLGVVQL VVGYSYRNCI EDQWSQRKSF HCTRRYFGNM SYMTQDLPVT
AVNLTISHCN VSRIDDSLSH LSNLQHLSIS PCNLRIIDMK AFQKLSKLKT LDLSFNELSE
LKPLLFEDLH NLHSLLLAHN KLRALPEEVF LNTLGLETLN MGTNLLTNFF NVAKSVSHLM
NLTVLDLSFN HFTSLSYSNV SLPRSLTKLS LSGNNLLTLG CQATLFNYVK LLDLSNNTKL
TAKAFQGVDL SHLNSLRLQL TNVDILKFLN ISNVSGVHVD FSGTGLKNKT QIEKLCELLK
KKHSIIKNLR LDYNGIRSTS FALHYCPTIT KALDLSHNNL KTIKCLGFLD GQEKITELYA
EHNHLTSLLP CKNKSKPALN KLEKLSYRYN RILSVSADAF HLTPNIKTLQ LNINSIAFFD
HHALKGLKKL HELRLDNNLL TDLFNDTFAN TYNLKILNLR NNRISVIFNG TFHYLKKLTI
LDLGGNKITQ FQAGGFDGLT NLSKLYLDGN NLKQIDTSFY YAFQDTLQVL DLNSNKIRFL
RDDKSSPFMN FSKLTDLKLG SQRPHGLTIL PRTLFRGLHS LKSLYLTNNK ISHIPHDAFD
DLTGLHFLTL DNCCVGRVNL QPGVFKNLRN LTKLVIENMG LQSFTREVFG NLTQLRILQA
NHNAMQSIPV DVLESLTKLQ YLDIRNVSLS CTCENILLQN YTLHNPDLQV IYLYNLQCPE
DKRRTFFNFN TEVCFIDLEK YLFFCTAVVI FLFTVTPLLH IKLYWKVKYG YYVFRAWFSD
HWSRIRDKEE NCQYDAFISY NSSDEEWVMD YLVPNLEGNK SPFKLCLHHR DFELGRDIVD
NIVNAVYSSR KTVCVVSRSF LCSEWCSLEI QLASYRLFDE HRDVLLLVFL EPISERQLSS
YHRMRKVMLK KTYLQWPGPD TTNLLQAQEL FWSQLRRAIR AGNRLETEDG IQESYAATDD
QTEKPCEDQT PDENCPLLV
//
