ID   A0A3B3DNY2_ORYME        Unreviewed;       931 AA.
AC   A0A3B3DNY2;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO3 {ECO:0000313|Ensembl:ENSOMEP00000031646.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000031646.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000031646.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR   AlphaFoldDB; A0A3B3DNY2; -.
DR   Ensembl; ENSOMET00000023124.1; ENSOMEP00000031646.1; ENSOMEG00000016644.1.
DR   GeneTree; ENSGT00940000156257; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF16; ANOCTAMIN-3; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        377..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        454..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        529..553
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        573..596
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        624..647
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        748..770
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        798..822
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          137..363
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          366..913
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
FT   REGION          77..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   931 AA;  108585 MW;  9CCDC513C94B4660 CRC64;
     MVHHSGSIQS FKQQKGMHTS ISEILKEKSL KPSRRSLPCL AQSQTHPINL NHFLSVPLSP
     DPKPEIEGLS QSISTSCSIL PPQTDGRENR VEETEVRTCE TRADQPFLLH KPVSRAKFGA
     RTVSQQEKDP ANSSGLFFRD GKKRIDYILV YKKSSPQVEK RCTFEKNLRA EGLMLEKEPS
     LTNNDIMFVK IHASWDTLCK YAERMNIRMP FRKKCHFSEM RSKGLGSRFH LRCRQIKNWF
     PRNPMKLDKE ALPDLEESDC YTAPFSRARM HHFKISNRET FFSNSTRSRI VHHVLQRTKY
     EDGKSKMGIN RLLGNNTYEA AFPPHEGGYK SRHPIKTHGP QNNRHLLYER WARWGIWYKY
     QPLDLIRRYF GEKIGLYFAW LGWYTGMLIP AALVGVFVFL YGLFTMDSSQ VSKEICEANT
     TTMCPMCEKT CDPWTLSDSC VYAKVTHLFD NGGTVFFAIF MAIWATVFLE FWKRRRAELT
     YDWDLIDWEE EEEELRPQFE AKYSRKERVN PISGKAEPFQ PFSDKLSRLM VSVSGIFFMI
     SLVLTAVFAV VVFRLIAMEK FASFKWHFVT KNLQFATSGT GVCLNFMIIM SLNVVYEKVA
     YLLTNLEHPR TESEWENSFS LKMFLFQFVN LNSSTFYIAF FLGRFAGRPG KYNKLFNRWR
     LEECHPSGCL IDLCLQMGVI MFFKQIWNNF MELGYPLLQN WWSRRKIKKG GGGGQNVESK
     SQLPQWDKDW NLQPMNAHGL VDEYLEMVLQ FGFTTIFVAA FPLAPFLALL NNIIEIRLDA
     YKFVTQWRRP MPARATDIGI WHGILEGIGV LAVITNAFVI AITSDYIPRF VYAFKYGPCM
     DKGHHHENEC LQGYVNSSLS VFDMWEVKNT SQSRYCRYRD YRAPPWSSVP YEFTLQFWHV
     LAARLAFIIV FEVCHRMQLN HNPLLIFLDY F
//