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Database: UniProt
Entry: A0A3B3DP62_ORYME
LinkDB: A0A3B3DP62_ORYME
Original site: A0A3B3DP62_ORYME 
ID   A0A3B3DP62_ORYME        Unreviewed;       714 AA.
AC   A0A3B3DP62;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=NAD(+) hydrolase SARM1 {ECO:0000256|ARBA:ARBA00024128};
DE            EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
DE   AltName: Full=NADP(+) hydrolase SARM1 {ECO:0000256|ARBA:ARBA00032222};
DE   AltName: Full=Sterile alpha and TIR motif-containing protein 1 {ECO:0000256|ARBA:ARBA00031160};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000031907.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000031907.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC         Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00000404};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC         Evidence={ECO:0000256|ARBA:ARBA00000404};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + NADP(+) = ADP-D-ribose 2'-phosphate + H(+) +
CC         nicotinamide; Xref=Rhea:RHEA:19849, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:58673; Evidence={ECO:0000256|ARBA:ARBA00023911};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19850;
CC         Evidence={ECO:0000256|ARBA:ARBA00023911};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NAD(+) = cyclic ADP-beta-D-ribose + H(+) + nicotinamide;
CC         Xref=Rhea:RHEA:38611, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:73672;
CC         Evidence={ECO:0000256|ARBA:ARBA00034259};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38612;
CC         Evidence={ECO:0000256|ARBA:ARBA00034259};
CC   -!- SIMILARITY: Belongs to the SARM1 family.
CC       {ECO:0000256|ARBA:ARBA00008291}.
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DR   AlphaFoldDB; A0A3B3DP62; -.
DR   STRING; 30732.ENSOMEP00000031907; -.
DR   PaxDb; 30732-ENSOMEP00000031907; -.
DR   Ensembl; ENSOMET00000023615.1; ENSOMEP00000031907.1; ENSOMEG00000017036.1.
DR   GeneTree; ENSGT00390000004155; -.
DR   OMA; KSCEVQT; -.
DR   OrthoDB; 5475697at2759; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR   GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR   GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0019677; P:NAD catabolic process; IEA:Ensembl.
DR   GO; GO:0034128; P:negative regulation of MyD88-independent toll-like receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0048679; P:regulation of axon regeneration; IEA:Ensembl.
DR   GO; GO:0048678; P:response to axon injury; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd09501; SAM_SARM1-like_repeat1; 1.
DR   CDD; cd09502; SAM_SARM1-like_repeat2; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001763; Rhodanese-like_dom.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR039184; SARM1.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR22998:SF1; NAD(+) HYDROLASE SARM1; 1.
DR   PANTHER; PTHR22998; SARM1; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   Pfam; PF07647; SAM_2; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   SMART; SM00454; SAM; 2.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50206; RHODANESE_3; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..714
FT                   /note="NAD(+) hydrolase SARM1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017440802"
FT   DOMAIN          356..438
FT                   /note="Rhodanese"
FT                   /evidence="ECO:0000259|PROSITE:PS50206"
FT   DOMAIN          412..476
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   DOMAIN          556..699
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   714 AA;  80658 MW;  E1C533727905D4B5 CRC64;
     MLFTPTFLLW RLFRHLCIMF SSDRLTVPEY VSRLQRGRSS SGGSDSKTAV SPGLSTDIQA
     VLNTSLPALR SAIRRLKSAQ ENSDSNETRR AVAEIYQLVE EAWVLPALGR QVAEEICNRI
     RLDGGLELLL QLQQTPEVEI IYESAKLLEQ ILISENRDYV ARLGLGVILN LARQQEDAQL
     ARSVSGILEH MFKHTEETSV HLISNGALDA LLFWCRGTDP TVLRHCAVAL ANCAMYGGHR
     CQRWMIEKQA AEWLFPLAFS KEDELIRFHA CLAVTVLAAN REIEKEVVKS GTLELVEPFI
     ASLDPDDFAR SLLDSADCMQ GKTASDLQHL LPLLDGTRVE GKCIAAFYLC VEASIKSRQR
     NTKIFQEIGA VQSLKRIVMY CSNGTACLLA KRALSMMGEE VPKRILSCVS NWKTCEVRVW
     LQQVGFSAYC DRFQELQVDG DLLLNITDQD LSSDLGMAAG LTRKRFLREL RVLKTYADYS
     TCDPNNMADW LAEVDPHFRQ YTYGMVQSGV DRNNVLNLND HQLQYDCHIE NGVHRAKILS
     ANRKPAKPCY TDAQPAGPDV FISYRRTTGS QLASLLKVHL QVRGYSVFID VEKLEAGKFE
     DKLIQSVQRA RNFILVLSAS ALDKCMGDTG MKDWVHKEIV TALTCKKNIV PVTDNFMWPE
     PASLPEDMRA ILNFNGIKWS HEYQEATIEK IIRFLKEPQD QTDRPKKSKE QEKK
//
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