ID   A0A3B3DP91_ORYME        Unreviewed;       459 AA.
AC   A0A3B3DP91;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Phosphoinositide-3-kinase regulatory subunit 1 {ECO:0000313|Ensembl:ENSOMEP00000031200.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000031200.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000031200.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC       {ECO:0000256|ARBA:ARBA00009442}.
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DR   AlphaFoldDB; A0A3B3DP91; -.
DR   Ensembl; ENSOMET00000022297.1; ENSOMEP00000031200.1; ENSOMEG00000015946.1.
DR   GeneTree; ENSGT00940000155553; -.
DR   Proteomes; UP000261560; Unplaced.
DR   CDD; cd12924; iSH2_PIK3R1; 1.
DR   CDD; cd09930; SH2_cSH2_p85_like; 1.
DR   CDD; cd09942; SH2_nSH2_p85_like; 1.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 2.
DR   InterPro; IPR044124; ISH2_PIK3R1.
DR   InterPro; IPR032498; PI3K_P85_iSH2.
DR   InterPro; IPR035020; PI3kinase_P85_cSH2.
DR   InterPro; IPR035022; PI3kinase_P85_nSH2.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR   Pfam; PF16454; PI3K_P85_iSH2; 1.
DR   Pfam; PF00017; SH2; 2.
DR   PRINTS; PR00678; PI3KINASEP85.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 2.
DR   SUPFAM; SSF55550; SH2 domain; 2.
DR   PROSITE; PS50001; SH2; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191}.
FT   DOMAIN          66..161
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          359..453
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   COILED          247..295
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   459 AA;  53652 MW;  E442B0DDE6F434E4 CRC64;
     MKWSGGLERS SVGFTVAFGN TADASKRGRI QANMLNSQPL PPKPPKPAAV INNGMNNNMA
     LQDAEWYWGE ISREEVNEKL RDTADGTFLV RDASTKMHGD YTLTLRKGGN NKLIKIFHRD
     GKYGFSDPLT FSSVVELINH YRNESLAQYN PKLDVKLLYP VSKQQQDQVV KEDNIEAVGR
     KLCEYHQQYQ EKNKEYDRLY EEYTRTSQEI QMKRTAIEAF NETIKIFEEQ CQTQERYSKD
     YIERFRKEGN EKEIQRIMGN YEKLKSRISE IVDSKRRLEE DLRKQAADYR EIDKRMNSIK
     PDLIQLRKTR DQYLTWLTQK GVRQKKLNEW LGIKNENTED QYSMVEDDED LPHHDERTWK
     LEKIDRLEAE GLLQGKRDGT FLVRESSKPG CYACSVVVDG EVKHCVINKT PSGYGFAEPY
     NLYSSLKELV LHYQHTSLVQ HNDSLNVTLA YPVFTQQRR
//