ID A0A3B3DPJ1_ORYME Unreviewed; 853 AA.
AC A0A3B3DPJ1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Endothelial PAS domain-containing protein 1-like {ECO:0000313|Ensembl:ENSOMEP00000032037.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000032037.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000032037.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR STRING; 30732.ENSOMEP00000015596; -.
DR PaxDb; 30732-ENSOMEP00000015596; -.
DR Ensembl; ENSOMET00000023815.1; ENSOMEP00000015596.1; ENSOMEG00000017236.1.
DR Ensembl; ENSOMET00000023873.1; ENSOMEP00000032037.1; ENSOMEG00000017236.1.
DR GeneTree; ENSGT00940000155930; -.
DR OMA; SGPNEKP; -.
DR OrthoDB; 5396877at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:Ensembl.
DR GO; GO:0048565; P:digestive tract development; IEA:Ensembl.
DR GO; GO:1990402; P:embryonic liver development; IEA:Ensembl.
DR GO; GO:0031017; P:exocrine pancreas development; IEA:Ensembl.
DR GO; GO:0060218; P:hematopoietic stem cell differentiation; IEA:Ensembl.
DR GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0030182; P:neuron differentiation; IEA:Ensembl.
DR GO; GO:0097150; P:neuronal stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0043523; P:regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0014823; P:response to activity; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR014887; HIF-1_CTAD.
DR InterPro; IPR021537; HIF_alpha-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR23043:SF8; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR Pfam; PF11413; HIF-1; 1.
DR Pfam; PF08778; HIF-1a_CTAD; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 14..67
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 89..151
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 246..297
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 585..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 400
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
FT MOD_RES 532
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
FT MOD_RES 830
FT /note="(3S)-3-hydroxyasparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
SQ SEQUENCE 853 AA; 93724 MW; 6B38C7627AD5F317 CRC64;
MTADKEKKRS SSERRKEKSR DAARCRRSKE TEVFYELAHQ LPLPHSVSSH LDKASIMRLA
ISVLRTRKLL ATRGGSDSDG DAHMDSLYLK SLEGFVTVVT TDGDMIFLSE NINKFMGLTQ
VELTGHSIFD FTHPCDHDEI KENLSLKTTG SVFGKKGKEL NTERDFFMRM KCTVTNRGRT
VNLKSASWKV LHCTGHLKMY DGCASRVLCG YKEPPLTCAV LMCEPIPHPS NIDTPLDSRT
FLSRHSMDMK FTYCDDKVTE LIGYAPEDLL GRSVYDFYHA LDSDSVTKSH HNLCTKGQAV
SGQYRMLAKN GGYVWVETQG TVIYNSRNSQ PQCIVCINYV LSDIEDRAVI LSLEQTESVF
QPQHMSSFFS AGGAGMNGEP GDSLFTTLKE EPDDLAQLAP TPGDTIISLD FGQSQFEEPQ
SSFTPASASG MPPLGASSWP SESHKPGPNA VPGEMATMGG AFTVQQNKPP GSATPSLSSC
STPSSPGDYY SSVDSDLKLE LTEKLFALDT EGNNSANTER DLSDLDLETL APYIPMDGED
FQLNPIIPEP EPLDSPGGAG SMANGSKLNI QQSFSDVASL FQPLTSPPQQ QGCYRPEPQS
SWATRERRGS GQGAVDARER SYMMGRMQTP PYQAPASGPL SSMQWPPDPI ITYQQSTRTP
KACLMDNLPE ERPSCQQNAS YLMQKPRSID NFVQAYKDMS PKASMGSSIK RSFNQMTVGE
MKPAEMIWKK MRDDSCMDRS LSAGSLTESA MGTAMPGSMS PFICSVQQHR KSQYTGSGAN
GKSFAQKSCS YSQYNMQSSS KSEGIASRLL GPSFEPSFLP ELTRYDCEVN VPLQGNLHLL
QGCDLLRALD QAT
//
