ID A0A3B3DPR6_ORYME Unreviewed; 546 AA.
AC A0A3B3DPR6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Wnt ligand secretion mediator {ECO:0000313|Ensembl:ENSOMEP00000031916.1};
DE SubName: Full=Wntless-like protein {ECO:0000313|EMBL:KAF6730786.1};
GN ORFNames=FQA47_003061 {ECO:0000313|EMBL:KAF6730786.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000031916.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000031916.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|EMBL:KAF6730786.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bigg-433 {ECO:0000313|EMBL:KAF6730786.1};
RX PubMed=32938378;
RA Liang P., Saqib H.S.A., Ni X., Shen Y.;
RT "Long-read sequencing and de novo genome assembly of marine medaka (Oryzias
RT melastigma).";
RL BMC Genomics 21:0-0(0).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004439}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the wntless family.
CC {ECO:0000256|ARBA:ARBA00008148}.
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DR EMBL; WKFB01000231; KAF6730786.1; -; Genomic_DNA.
DR STRING; 30732.ENSOMEP00000031916; -.
DR PaxDb; 30732-ENSOMEP00000031916; -.
DR Ensembl; ENSOMET00000023681.1; ENSOMEP00000031916.1; ENSOMEG00000017038.1.
DR GeneTree; ENSGT00390000005897; -.
DR OMA; EGQWKWD; -.
DR OrthoDB; 3016042at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR Proteomes; UP000646548; Unassembled WGS sequence.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017147; F:Wnt-protein binding; IEA:InterPro.
DR GO; GO:0060536; P:cartilage morphogenesis; IEA:Ensembl.
DR GO; GO:0044566; P:chondrocyte activation; IEA:Ensembl.
DR GO; GO:0035988; P:chondrocyte proliferation; IEA:Ensembl.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0001958; P:endochondral ossification; IEA:Ensembl.
DR GO; GO:0021986; P:habenula development; IEA:Ensembl.
DR GO; GO:0001957; P:intramembranous ossification; IEA:Ensembl.
DR GO; GO:0030917; P:midbrain-hindbrain boundary development; IEA:Ensembl.
DR GO; GO:0060872; P:semicircular canal development; IEA:Ensembl.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR047843; WLS-like_TM.
DR InterPro; IPR009551; Wntless.
DR PANTHER; PTHR13449; INTEGRAL MEMBRANE PROTEIN GPR177; 1.
DR PANTHER; PTHR13449:SF2; PROTEIN WNTLESS HOMOLOG; 1.
DR Pfam; PF06664; MIG-14_Wnt-bd; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000646548};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 178..496
FT /note="Wntless-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF06664"
SQ SEQUENCE 546 AA; 62695 MW; FDAAB1FDE3078AA4 CRC64;
MAGAIIENMS TKKLVIVGVT LLLFQALAFM VGGLIAPSPT TAVHYLATKC VDTVKSQQET
KWFMPWGPNQ CDKLQSFDDA MAKRIEANDI VFAVHIPLPK KEMSPWFQFM LVILQFDIAF
KMYNQIEEGA MVNIEVGLAY RDDTVSPWTE MARSFEQRRL NCSFTTAKTV ENEGRHYECD
LLPFMELGSV AHKYYLLNIR LPVNERKKIN VKIGEIKDIR LVSIHQNGGF TKVWFAMKTF
LTPSILIIMI WYWRRISLMS RPPVLLEKVI LALGISMTFI NIPVEWFSIG FNWTWMLLFG
DIRQGIFYSM LLSFWIIFCG EHLMDQTERN RFSVYWKQVG PIVFGSFCLF IFDMCERGVQ
LTNPFYSIWA SDVGTELAMA FIIVAGICAC LYFLFLCFMV YQVFRNISGK RTSLPAMTKA
RRLHYEGLIF RFKFLMLVTL ACAAMTVIFF IISQVNEGHW HWGEHTVQVN SAFFTGIYGM
WNLYVFAIMF LYAPSHKRYG DEQSSGQCIT GDGGANSGED LQLTTTITHV DGPTEIYKMT
GKEAQE
//
