ID A0A3B3DQ08_ORYME Unreviewed; 2142 AA.
AC A0A3B3DQ08;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|RuleBase:RU364134};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000032011.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000032011.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
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DR STRING; 30732.ENSOMEP00000032011; -.
DR PaxDb; 30732-ENSOMEP00000032011; -.
DR Ensembl; ENSOMET00000023798.1; ENSOMEP00000032011.1; ENSOMEG00000017190.1.
DR GeneTree; ENSGT00390000013680; -.
DR OMA; WWGEDPS; -.
DR OrthoDB; 9289at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF4; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF11597; Med13_N; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 11..257
FT /note="Mediator complex subunit Med13 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11597"
FT DOMAIN 1370..1699
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1735..2131
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 437..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 988..1059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1475..1603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1990..2019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..754
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..821
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1008
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1013..1027
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1059
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1491..1586
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2142 AA; 235090 MW; 8060947090090611 CRC64;
MSSCFVPNGA SLEDCHSNLF CLADLTGIKW KMFVWQGPTS APILFPVTEE DPILCSFSRC
LKADVLSVWR RSQRPGRREL WLFWWGDDPN FTELIHHELT AGDDGLWENG LPYECRTLLF
KAIHNLLERC LMNRSFVRIG KWFVKPYEKD EKPVNKSEHL SCAFTFFLHG ESNVCTSVEI
NQHQPIYHLT EEHLTLAQQA SSPFQVILSP FGLNGTLTGQ SFKMSDPPTQ KLIEEWNQFY
PISPSAKETV SEDKPEDMDW EDDSLASVEV LVGGVRMVYP ACLVLVPQSD IPVVAPVGSS
QCTAVYSGGH QVPAMQREPA MSLVTLTPPT SPEEVHTVDS HSAQNWLKMP SSSDVFSVDR
TSHHGGKVPR QLASQVVECV WQECNINRAQ NKRKFSATSN GTCEEEVLEK VGAWDFVEPS
QRSYCVCSRH KSVKQRASAA QGQTQSTGQP SQPLTKHKTG GEKADKGEKQ QKRPQTPFHH
RSLASEETSM EAEATVGQRL SLRGQDGGRF RSADVNTIPK APQLQSGRIS TGPSEQVNSP
QPPPLSPHPC EPGEDSGEGL RNPSTPNSQH FYQPPLEPCH IGVKGGSEDP GGLVCLNQHF
HSSHPHPHSG SSALTEPPEP TMFVGAAINL EDDCSLTPWR LYNLPRAKEA EVPTPVLPVD
RLRDDILPQE PVSATDLMST SKCSLKVSEE RVQKYRARRN QYLSAAISDG GHELEVDPYA
FEEGDDKFVF SSKKDKSGEE REPGNKHKGE DGGAGASDDA QCSVAHNRMA SASLIHVTDL
VVSINDLDNL FNSDEDDLAP GSKRLERTDE KGTKRPSTKE PKPSTLDPVS CISSAELHQM
YPTPPSLEQH IMGYSPMNMS SKEYGSMEPN TGMMLDGIST LGGHFKIEVE ESFCSPKPSE
VKDFSFVYKS ELFQPFVGCS MFAPLKTLPS QCLPPIKTLE DCIYRPSWSM GREMLNQAPV
MTFLHKDSNI PSVGSTMDQD YSQTYTPQTQ APFASSSAPP SNSGAGILPS PATPRFAPTP
RTPRTPRTPR GPSSVQGSLK YENSDLYSPA STPSTCRPLN SVEPATVPSI PEAHSLYVTL
ILSESVMNLF KDCNFDSCCI CVCNMNLKGA DVGVYLSDPV SEAQEPCSCG FSAVVNRRYG
NGSGLFLEDE LDIIGRGTDV SREVEKRFEE LRLSGVGRGD RVPDELILLL QDQCTNPFSA
IVTVEHDRVK RGPSGDPVPP CVRVEERDFC SDCYMALKHG REFMDSMSGG KVDEVLVKST
CLHQWAKENA VDVSALCSQD VLRVLLSLQP VLQDAIQKKR TIRSWGVQGP LTWQQFHKMA
GRGSYGTDES PEPLPIPTFL VGYEYDFLVL SPFALPYWEK LLLDPFGSQR DIGYLVVCPD
NEALLSGAKS FFRDLTSVYE SCRLGQHRPI SRGYPDGIVL VGGSEAQSLA DKPVSDWFLK
AASGNSDAFT KLKLYAQVCR HNLAPYLSSQ PLDASLLTQP CPPPTPNQPL STQQPSSASS
TASQQGSSSI PPSSSGGGSA NASASLHGHS ASSGQPVSSL PSAKPSSFPP FGSMGSSQSG
QLGQQAGAQN TGDASSTLTQ GSTEPPESTL EREKVGVPTD GESHAVTYPP AIVLYIVDPF
SYEDADGCSG QLDSSVWTLS LLRCYLEMLQ SLPPHIQNSI SVQIVPCQYL LQPVRGEHRH
IYAQHLKSLA FSAFTQCRRP LPFSTNVKSL TGFGPGLAID TALRSPERPE CLRLYTPPFI
LAPVKDKQTE LGETFGEASQ KYNVLFVAYC LSHDQRWLLA TCTDLYGELL ETCIINVDVP
NRARRKKGSG RLLGLQKLWE WCLGLVQMTS LPWRVVIGRL GRIGHGELKD WSILLSRRSL
QSLSRRLKEM CRMCGISASD TPSILSVCLV AMEPQGSFVI MPDSVSTGSV FGRSTTLNMQ
TSQLSTPQDT SCTHILVFPT SAFVQITSSN YTNIDTNIDI LNGTNDAIGI FDLLDPENEL
VDPDIINISP PTSPVHSPGS HYHHGGDGSK GSNTNHMPSL EEVPNLLQQP LALGYFVSTA
KAGPLPDWFW SACPQAQNQC PLFLKASLHL HVSSVQSDEL LHSKHSHPLD SNQTSDVLRY
VLEQYNALSW LTCDPATQDR RSCLPLHFVV LNQMYNFIMN ML
//
