ID A0A3B3DT96_ORYME Unreviewed; 604 AA.
AC A0A3B3DT96;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Perforin-1-like {ECO:0000313|Ensembl:ENSOMEP00000033151.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000033151.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000033151.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
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DR AlphaFoldDB; A0A3B3DT96; -.
DR Ensembl; ENSOMET00000034759.1; ENSOMEP00000033151.1; ENSOMEG00000019169.1.
DR GeneTree; ENSGT00940000164067; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR PANTHER; PTHR46096; PERFORIN-1; 1.
DR PANTHER; PTHR46096:SF3; PERFORIN-1; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..604
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017227903"
FT DOMAIN 26..380
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 402..520
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 604 AA; 68788 MW; 62D4C1CCAD04DC07 CRC64;
MFPVKLPLFV LLFFPKCAFE QCIKGTPKEC QEAEFAPGSN LAGEGFDITK MERKGFFVLD
MNQWKHSDQA CTLCDNPDFE NRKQKLPLSV EDWRAKHFCS AKVSSKVYKS SESLVESTTS
SIENNWKVGL SVNMIDKSGS FMLVGTDSKL AVNSMEKTKS DKFSFTTQSV SCEYYSYRVS
KAPTVKKEFL DSVNQLPKVY NPQSKNNYYH LIDTFGTHYI TWLGWHSHNV SFQVKMGGKV
NAVTSIRECE AHLDGIEVNE METCLTVEAS ATVKATTISA ENQHCKAKKD KTRRKITFSS
YFNDRFTEVK GGQKTEPDLI FSANSDPSAY KEWLNSVPRN PDIISYSLDS LHELIPKSDP
MKENLRSAIS HYILEKGLLK SCTDPCKAGI KSSSREPCVC QCHNDPAVTS DCCPNQRGNA
RVKITILRAF NLYGDYRTAT DAYVIVKLLG KLVGRTSVIS NDDNPKWNMV LDMGDQVLSE
VSKLKFEVWD EDNTWDDDLL GECERVLTAG INNGECFFEY GKFLFKWKVD CAPNLSGRYC
QNYQSSPMNE DLKELYRSRH SHPIPKYFLQ QMGVFVNEST SRKIFKGNKT QTFFFYLKYK
VRIL
//
