ID A0A3B3DUX2_ORYME Unreviewed; 1458 AA.
AC A0A3B3DUX2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Calmodulin-regulated spectrin-associated protein 2-like {ECO:0000313|Ensembl:ENSOMEP00000033908.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000033908.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000033908.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- DOMAIN: The CKK domain binds microtubules. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
CC -!- SIMILARITY: Belongs to the CAMSAP1 family. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
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DR STRING; 30732.ENSOMEP00000033908; -.
DR PaxDb; 30732-ENSOMEP00000033908; -.
DR Ensembl; ENSOMET00000027452.1; ENSOMEP00000033908.1; ENSOMEG00000020226.1.
DR GeneTree; ENSGT00950000182975; -.
DR OrthoDB; 2918432at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-UniRule.
DR GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0030507; F:spectrin binding; IEA:InterPro.
DR GO; GO:0031175; P:neuron projection development; IEA:InterPro.
DR CDD; cd22265; UDM1_RNF168; 1.
DR Gene3D; 3.10.20.360; CKK domain; 1.
DR InterPro; IPR032940; CAMSAP.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR031372; CAMSAP_CC1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR038209; CKK_dom_sf.
DR InterPro; IPR014797; CKK_domain.
DR InterPro; IPR011033; PRC_barrel-like_sf.
DR PANTHER; PTHR21595:SF1; CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 2; 1.
DR PANTHER; PTHR21595; UNCHARACTERIZED; 1.
DR Pfam; PF17095; CAMSAP_CC1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR Pfam; PF08683; CAMSAP_CKK; 1.
DR SMART; SM01051; CAMSAP_CKK; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50346; PRC-barrel domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51508; CKK; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|PROSITE-
KW ProRule:PRU00841}.
FT DOMAIN 210..334
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1318..1452
FT /note="CKK"
FT /evidence="ECO:0000259|PROSITE:PS51508"
FT REGION 366..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 848..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 949..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1135..1172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1195..1232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1280..1323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 694..721
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 802..829
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 569..584
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..792
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..891
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1286..1319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1458 AA; 162107 MW; 33689392B0220E77 CRC64;
MGEVQEDKDV KRTFNAPAIK SFEYYDFSRA KICSSLTWLV AKAYGTDSIP TDLKNPFYTD
QYEQEHLKPP VASLLLSADL YCRAGSLILR SDAAKPLLGH DAVIQALAQR GLYVTDQDRL
VTERDLRKRP LQMSAHLAMI DTLMMAYTVE TVSVEKATAC IRQYSSYNPE VDTSFDTEDA
VTSWINTVNE CLKEIVTHEQ KKETQSLEPA GSPRSPTKWY MKLVPARYRK EQPSTQQTLW
IPPVDNLLKD TTDGSALAAL IHFYCPQVLP LEDICLKENM TLADRLYNLQ LIQDFCKDNL
NSCCHFSLED MLYASSTIKN NYLVFMAELF WWFEVVKPSF VKPRIMDVEE SSSLIKNLPA
VSKATKRSFM EQPPSPDRPS LPLRPQTGNS GEIKRSTSMS FVDGNLGTWP KEKRSGPYGV
SFDIPFDRED SASASLSSRG MVRSISTDDG SGFKVHHMPR GMKRNLSFQP VNGQSIGIDE
EGCPDSLAGL QPIRREYPNG HGSGLEKAPS MEEALQIIHS PSRPPVEGIS NGFFLHSQSH
GAAAGGLDPV SELDSKEALS PTETTEVDTG IHIRTEDMLD EDSSLRDCSV NMELDVETPS
PSPSSQSKSP SAIKMTSFAE QKMRKLSPSA QDSGRGSSSS MKTTPEGSEL GLPLSVSWAP
TPEHSPVHQQ AAAPAPAPVQ LPPNDPAQVM ATEMVHLRMR LEEKRKAIEA QKKKVEAAFT
RHRQKMGHSA FLNVVKRKGD GAASEEGSKT EGEGKSVSTF KFGRNIADTP DGAEQSSKAS
CWQKTPAAGE EQSHSHVTEV DLSEYTRSIE KLNHSLAFLQ AEMQRLAHQQ EVIMAMREQQ
HQQAWVIPPS YANPSPQKHT RAVIRSSGPS SPADSPHSTH RSPTNIKRKS ASFHSRNPRA
ARPNELKLTP YNRVLTAPQS VDSIPRLRRF SPCQPLVSSF IYMGEKPAAA GPETVAPPED
HNKETDSASS PEKEIPNILA ASSPPSSPNM QRKGEVDGDE QTQEGENPSN FPDIKKDGLN
DRVQNSFIEP KPTVEFPEVL ALPVVETFTV TPTEMPPQPQ PASPAKSCLI EVPLSVMELP
EALMMEDALE AEQDSVESVD EEQRMCHGFF FKDDGKAEEN MAQKRAALLE KRMRREKENQ
QRKVQLEAEL EQKKEEARLK AEEERVRKEE DKARKEFIKQ EYLRRKQLKL MEDMDSIIKP
RAGGGTKQRR SRPKSMHRDS IDSPKTPARA ATVSSLSLAS LNLGDSDSTQ SDKRASRRAS
LASSSLFYFL NSPKLRRMRP ESADGFLSPS RSSSRNGERD WENASTTSSV TSNTEYTGPK
LYKEPSAKSN KHIIQNALAH CCLAGKVNEG QKNKILEEID KSEANNFLVL FRDAGCQFRA
LYTYCPETEE IAKLTGIGPR GITRKMIDGL YKYNSDKKQF SQIPAKTMSA SVDAVTIHNH
LWQTKKPVTP KKVVPAPS
//
