ID A0A3B3DV28_ORYME Unreviewed; 686 AA.
AC A0A3B3DV28;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Complement factor B-like {ECO:0000313|Ensembl:ENSOMEP00000033299.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000033299.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000033299.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR AlphaFoldDB; A0A3B3DV28; -.
DR Ensembl; ENSOMET00000034857.1; ENSOMEP00000033299.1; ENSOMEG00000019236.1.
DR GeneTree; ENSGT00940000158605; -.
DR OMA; YDCYSGY; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00033; CCP; 2.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR011360; Compl_C2_B.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR46393:SF6; COMPLEMENT COMPONENT BFB-RELATED; 1.
DR PANTHER; PTHR46393; SUSHI DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00084; Sushi; 2.
DR Pfam; PF00089; Trypsin; 2.
DR Pfam; PF00092; VWA; 1.
DR PIRSF; PIRSF001154; Compl_C2_B; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00032; CCP; 2.
DR SMART; SM00020; Tryp_SPc; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50923; SUSHI; 2.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..686
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017368794"
FT DOMAIN 19..78
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 82..139
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 185..384
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 402..672
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT ACT_SITE 444
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR001154-1"
FT ACT_SITE 496
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR001154-1"
FT ACT_SITE 615
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR001154-1"
FT DISULFID 49..76
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 110..137
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 686 AA; 76388 MW; 72509607D4B6550E CRC64;
MCFCVCNICY SSLFCAADVE CPDPNVLENG NVSPPLERYL AGNTTTFECY SGYTLRGSES
RTCLPNGKWS GSTTICSRDS GETCPDPGVP PGASRRGNTF DVGYDVSYSC NGNLFLVGSK
VRVCQENGHW SGREPACYSK FTYDTSQEVS EAFGSSIRET LTTLQSTNDT QAGRKIRISK
NGTLNIYIAL DISESIEEKH FKKAKEAIIT LIKKISTFTV TPNYEIIFFS SEVFEVANIV
DFYSGTENLI SVIKKLEAFK IGDKSTGTDV NAALKTFEDR MAWIEEREKE NFRKHRHVFL
LFTDGAYNMG GSPLPTLARI KSRVYMSPTG DPGSRLEYLE SYVFGIGAVI FDDDLQPLTA
GTEEEKHYFR LEKETNLAAT FDSIIDENEV IGLCGLHRTY DLLGNKASIK AMYPWVVFIN
IQGESPKKCL GSLVSPEFVL TAAHCFIFSD EPKNVQVEIE DGHGSKNKKV KTFKLHPQYN
VTARKNQGVE EFYDYDVALI QLEKPVNISH SARPICIPCT KQTKDALRLP PSSTCKDQEE
LLLKNQQERL SFLTRLEPLV GEKDVYAKLG DSRDLCIKKA LEAKGIKAKD PKIPVTDNFL
CTGGEREHIA CTGDSGGAVF KNYEDRTIQI ALVSWGTQEL CTGGGMIEST EKSRDFHINL
FKMIPFLKEI MGNDDSDDFA SIGFID
//
