ID A0A3B3DW91_ORYME Unreviewed; 673 AA.
AC A0A3B3DW91;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000034407.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000034407.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3B3DW91; -.
DR STRING; 30732.ENSOMEP00000034407; -.
DR PaxDb; 30732-ENSOMEP00000034407; -.
DR Ensembl; ENSOMET00000035585.1; ENSOMEP00000034407.1; ENSOMEG00000021051.1.
DR GeneTree; ENSGT00940000166603; -.
DR OMA; ERCELNQ; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR PANTHER; PTHR46513:SF31; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF00058; Ldl_recept_b; 2.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS51120; LDLRB; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 550..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 124..167
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 168..211
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 342..375
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 378..414
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 415..447
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 450..486
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 80..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..673
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 346..356
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 382..392
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 404..413
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 418..428
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 454..464
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 476..485
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 673 AA; 75266 MW; 00661901D7ED2B97 CRC64;
MCTCHKPFSK HNHTCKTDSQ KHLYIADDNE IRSLDPSVSN WRYEQIFQGD ANVRIDAMDL
HVKTNRIYWT NWHTRRISSY DLPSSSTSSQ NSNRNRRQSD TRVTNLDIPD LKMPRGIAVD
WVAGNLYWTD SGRDVIEVAQ MNGGHHRKTL ISGMIDEPHS IVVDPQRGKM YWTDWGNHPK
IETAAMDGTM RETLIDKNIQ WPTGLAVDYF NERLYWADAK LSLICSVRLN GSDAVVAVNG
VKNNLHHPFS IDVFEDYIYG VTYINNHVFR VNKFGKGQVE DLTTGLNHAT SLVLYNRYKQ
PEVALSAEPQ WTGLHLSQRT HAGQRHMCGA AYTHTLFPTA PPSGPCTVQC MNGGSCFLNA
HKQPKCRCQP NFGGERCEID HCMDYCKNGG TCTPSPTGFP TCRCRIGFTG PKCNLHTCRD
NCKNGGNCTV SPGNQPTCHC PADFLGDQCQ YRSCEGYCLN KGTCLQRDNG SKVCRCPPQF
TGSTCEIDRC HYCRDGTCIP SDGVSSTGEV TCRCKNGRIQ PSCYTCETNG YCANGQCFMN
PITRLPECTA SIVVTVLILL LLVLLGVGAL LWYRRRMRGA KGFQHQRMTN GAMNVEIGNP
AYKIYEGEPD DDAGELLDAD FTLDPDKPTN FTNPVYATLY MGAHNSRNSL ASTDEKKELL
SRGDEERLVD PLA
//
