ID A0A3B3DXP1_ORYME Unreviewed; 1959 AA.
AC A0A3B3DXP1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=EMAP like 5 {ECO:0000313|Ensembl:ENSOMEP00000034691.1};
GN Name=EML5 {ECO:0000313|Ensembl:ENSOMEP00000034691.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000034691.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000034691.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic.
CC {ECO:0000256|ARBA:ARBA00003210}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR STRING; 30732.ENSOMEP00000034691; -.
DR PaxDb; 30732-ENSOMEP00000034691; -.
DR Ensembl; ENSOMET00000028931.1; ENSOMEP00000034691.1; ENSOMEG00000021512.1.
DR GeneTree; ENSGT00940000156613; -.
DR Proteomes; UP000261560; Unplaced.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 6.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF16; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 5; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 2.
DR Pfam; PF03451; HELP; 3.
DR Pfam; PF00400; WD40; 12.
DR SMART; SM00320; WD40; 29.
DR SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR SUPFAM; SSF101908; Putative isomerase YbhE; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 3.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
PE 3: Inferred from homology;
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 4..48
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 250..265
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 330..354
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 381..461
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT DOMAIN 664..715
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 896..926
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1231..1263
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1337..1398
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 1693..1721
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1732..1811
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REGION 606..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..632
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1959 AA; 218480 MW; 06EB8BEB1B9671FB CRC64;
MADRTAPNCH LRLEWVYGYR GHQCRNNLYY TAAKEIVYFV AGVGVVYNTR EHKQKFYLGH
NDDIISLALH PERVLVATGQ VGKEPYICVW DSYTVQTVSI LKDVHTHGIA CLAFDLEGQC
LVSVGLDSKN TICVWDWRRG KVLAVAPGHT DRIFDISWDL YQPSKLVSCG VKHIKFWSLC
GNALTPKRGV FGKTGDLQTI LCLACAKDEI TYSGALNGDI YVWKGINLLR TIQGAHGSGI
FSMNACEEGF ATGGRDGCVR LWDLNFKPIT VIDLRETDQG YKGLSVRSVC WRGDHILVGT
QDSEIFEVVV HDRNKPFLIM QGHCEGELWA LAVHPTKPLA MTGSDDRSVR IWSLIDHALI
ARCNMEEPIR CAAVSTDGIH LALGMKDGSF TVLRVRDMTE VVHIKDRKEA IHELKYSPDG
AHLAVGSNEN SVDVYGVVQR YKKVGECMGS NSFITHMDWS TDSKYLQTND GSGRRLFYRM
PSGKEVTNRE ELKLVQWASW TCVLGPEVNG IWPKYSDIND INSVDGNFSN QVLVTADDYG
LVKLFRYPCI KKGAKFKKYL GHSAHITNAR WSHDYQWVIT IGGADHSVFQ WKFVPERKSK
EALHIAPQET LADSNSEESD SDQSDVPEMD SEIEQETQLT YRRQVYKEDL PQLKEQCKVK
HRATAMKKRE RAPASGIKLH FIHGYRGYDC RSNLFYTQTG EIVYHVAAVG VVYNRQQNTQ
RFYMGHDDDI LCLAIHPLKD FVATGQVGRD SSVHIWDTET LKPMSVLKGS HQLGVCALDF
SADGKRLVSI GLDDNHTIVL WDWKKGEKLS AMRGSKDKIF VVKINPYVPD KLITAGVKHM
KFWHKAGGGL IGRKGNMGKT ETMMCAVYGW SEEMVFSGTC SGDICIWRDM FLMKTVKAHD
GPVFSMHALE KGFVTGGKDG IVALWDDTFE RCLKTYAIKR AVLAPGSKGL LLEDNPSIRA
ISLGHGHILV GTKNGEILEV DKSGPITLLV QGHMEGEVWG LASHPHLPLC ATVSDDKTLR
IWDLSPSHCM LAVRKLRKGG RCCCFSPDGK ALAVGLNDGS FIIVNADTLE DLVSFHHRKD
AISDIRFSPG AGKYLAVASA DSFVDIYNVM SSKRVGVCKG CLSYITHLDW DKRGKLLQVN
TAAKEQFFFE APRGKRQTIP ASEVEKIDWC TWTCVLGPSV EGTWPVISEV TEVTAACLSN
DRQVLATGDD LGYVKLFRYP AKGKYAKFKR YVAHSTHVTN VRWSHNDSLL VTVGGGDTCL
MIWAHELEGL REFKQCDSEE SDIESEDDGG YDSDVTRENE ISYTIKALST NMRAMTGVKP
HLQLKEPSVD ERPPVSRALP QPEKLQTNNV GKKKRPIEDL VLELVFGYRG SDCRNNVHYL
NEGADIIYHT ASVAIVLNLT TSCQSFYLEH SDDILCLTIN QHPKFPNVVA TGQVATSPSI
HVWDAMTKQT LSVLRCFHSS GVCSVSFSAT GKLLLSVGLD PEHTVTIWKW QEGAKVASRV
GHSQRIFVAE FRPDSDTHFV SVGIKHVRFW TLAGRALLSK KGVLSSIEDA RMQTMLSVAF
GANNLTFTGT ISGDVCVWKE HILVRIVAKA HTGPVFTMYT TLRDGLIVTG GKERPSKEGG
ALKLWDQELK RCRAFRLETG QIIDCVRSVC RGKGKILVGT RNAEIIEVGE KNAACNILVN
GHMDGPIWGL CTHPSRDVFL SAAEDGTVRL WDIPEKKMLN KVNLGHPAHA ISYSPEGDMV
AIGMKNGEFI ILLVASLKIW GKKRDRRSAI QDIRFSPNSR YLAVGSTECA VDFYDLTLGP
QLNRINCCRD IPSFVMQMDF SADSNHIQLS TGAYKRLVYE VPSGKQITEQ FHIDRITWAT
WTSVLGDEVI GIWSRNTEKA DVICACVSHS GLNIITGDDF GMVKLFDFPC LEKFAKHKRF
LGHSAHLTNI RFTNGDRFVV SAGGDDRSLF VWRCVHSLH
//
