ID A0A3B3DYI1_ORYME Unreviewed; 275 AA.
AC A0A3B3DYI1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Synapse differentiation-inducing gene protein 1 {ECO:0000256|ARBA:ARBA00040240};
DE AltName: Full=Dispanin subfamily C member 2 {ECO:0000256|ARBA:ARBA00041354};
DE AltName: Full=Transmembrane protein 90B {ECO:0000256|ARBA:ARBA00042246};
GN Name=SYNDIG1 {ECO:0000313|Ensembl:ENSOMEP00000035183.1};
GN ORFNames=FQA47_008047 {ECO:0000313|EMBL:KAF6731993.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000035183.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000035183.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|EMBL:KAF6731993.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bigg-433 {ECO:0000313|EMBL:KAF6731993.1};
RX PubMed=32938378;
RA Liang P., Saqib H.S.A., Ni X., Shen Y.;
RT "Long-read sequencing and de novo genome assembly of marine medaka (Oryzias
RT melastigma).";
RL BMC Genomics 21:0-0(0).
CC -!- FUNCTION: May regulate AMPA receptor content at nascent synapses, and
CC have a role in postsynaptic development and maturation.
CC {ECO:0000256|ARBA:ARBA00037790}.
CC -!- SUBUNIT: Homodimer. Interacts with GRIA1 and GRIA2.
CC {ECO:0000256|ARBA:ARBA00038680}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Cell projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Cell
CC projection, dendritic spine {ECO:0000256|ARBA:ARBA00004552}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}. Postsynaptic density membrane
CC {ECO:0000256|ARBA:ARBA00034112}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the CD225/Dispanin family.
CC {ECO:0000256|ARBA:ARBA00006843}.
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DR EMBL; WKFB01000201; KAF6731993.1; -; Genomic_DNA.
DR Ensembl; ENSOMET00000029897.1; ENSOMEP00000035183.1; ENSOMEG00000022278.1.
DR GeneTree; ENSGT00950000183147; -.
DR OMA; AYFSKNH; -.
DR OrthoDB; 4253341at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR Proteomes; UP000646548; Unassembled WGS sequence.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007593; CD225/Dispanin_fam.
DR PANTHER; PTHR14768:SF3; SYNAPSE DIFFERENTIATION-INDUCING GENE PROTEIN 1; 1.
DR PANTHER; PTHR14768; UPF0338 PROTEIN; 1.
DR Pfam; PF04505; CD225; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000646548};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 199..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 275 AA; 30108 MW; D267989D16640962 CRC64;
MEGEGEDRRW TEEVEVSYKH WRTPPRGGPG GRVSCKQNGL IDTHRLGAEP TEALLPAYTI
PHCQGHEGLR EHSGPPQLLN PGALLPHQAA PEPILRPAPG LLLCRESLLQ MWGEAGGGDC
CETTFIEGHG HDNSAPCSPK EVLLYADSKF LEYSGEGARI PSLSYDIDDD DDFQELESDY
SSESESEDAF LLLPPRDHLG LSVFSMLCCF WPLGIAAFYL SHETNKAVSK GDFHLASSSS
RRALFLAVLS ITIGTGIYVG VAVALIAYFS KNHQW
//
