ID   A0A3B3DYT4_ORYME        Unreviewed;       579 AA.
AC   A0A3B3DYT4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Solute carrier family 40 member {ECO:0000256|RuleBase:RU365065};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000035283.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000035283.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: May be involved in iron transport and iron homeostasis.
CC       {ECO:0000256|RuleBase:RU365065}.
CC   -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC       {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC       {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU365065}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU365065}.
CC   -!- SIMILARITY: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A
CC       subfamily. {ECO:0000256|ARBA:ARBA00006279,
CC       ECO:0000256|RuleBase:RU365065}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU365065}.
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DR   AlphaFoldDB; A0A3B3DYT4; -.
DR   STRING; 30732.ENSOMEP00000035283; -.
DR   PaxDb; 30732-ENSOMEP00000035283; -.
DR   Ensembl; ENSOMET00000036175.1; ENSOMEP00000035283.1; ENSOMEG00000022479.1.
DR   GeneTree; ENSGT00390000015143; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd17480; MFS_SLC40A1_like; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR009716; Ferroportin-1.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR11660; SOLUTE CARRIER FAMILY 40 MEMBER; 1.
DR   PANTHER; PTHR11660:SF47; SOLUTE CARRIER FAMILY 40 MEMBER 1; 1.
DR   Pfam; PF06963; FPN1; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion transport {ECO:0000256|RuleBase:RU365065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365065};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU365065};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU365065};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365065}.
FT   TRANSMEM        72..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        109..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        321..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        353..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        388..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        456..476
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        526..546
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   REGION          252..292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        263..289
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   579 AA;  63420 MW;  85F63E2CE8F48E78 CRC64;
     MTVQRESIVW GIVYLQQPNR MSIFGLFAES IRDFFTSAKF LIYMGHALST WGDRMWNFAV
     SVFLVELYGN SLLLTAVYGL VVAGSVLLLG AIIGDWVDKN PRLKVAQTSL LVQNSCVILC
     GVLLMLVFQF KEQLVELYNG WILTVCYILV ITIANIANLA STATSITIQR DWVVVVAGQD
     SSKLADMNAT VRIIDQLTNI LAPMLVGQIM TFGSHFVGCG FISGWNLCSM CVEYALLWKV
     YQKTPALAEK AGQKEQELKQ LSPSRDAENG QSPEESSQPL MNETAVVSSP DSPKKEGCCY
     QVAEPLRTFK GGWVAYYNQN IFLAGMSLAF LYMTVLGFDC ITTGYAYTQG LSGSVLSLLM
     GASAISGICG TVAFTWIRKK CGLIRTGFIS GVAQLSCLML CVASVFAPGS VFDLSVSPFQ
     DLYTHLMGEQ SLPEADHSLI NMNVTTVAPA EEMPPLQSYM SVSLLFAGVI AARVGLWSFD
     LTVTQLIQEN VIESERGVIN GVQNSMNYLL DLLHFVMVIL APNPEAFGLL VIISVSFVAL
     GHLMYFRYAF KSLGSRLFLC CSPEQKVETV DTLSLPTTV
//