ID   A0A3B3DZ29_ORYME        Unreviewed;      2053 AA.
AC   A0A3B3DZ29;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Dedicator of cytokinesis 8 {ECO:0000313|Ensembl:ENSOMEP00000035181.1};
GN   Name=DOCK8 {ECO:0000313|Ensembl:ENSOMEP00000035181.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000035181.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000035181.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00983}.
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DR   STRING; 30732.ENSOMEP00000035181; -.
DR   PaxDb; 30732-ENSOMEP00000035181; -.
DR   Ensembl; ENSOMET00000029890.1; ENSOMEP00000035181.1; ENSOMEG00000022364.1.
DR   GeneTree; ENSGT00940000155876; -.
DR   OMA; MMERKIP; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:1904124; P:microglial cell migration; IEA:Ensembl.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd08696; C2_Dock-C; 1.
DR   Gene3D; 1.20.58.740; -; 1.
DR   Gene3D; 1.25.40.410; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR037808; C2_Dock-C.
DR   InterPro; IPR027007; C2_DOCK-type_domain.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR026791; DOCK.
DR   InterPro; IPR021816; DOCK_C/D_N.
DR   InterPro; IPR043161; DOCK_C_lobe_A.
DR   InterPro; IPR043162; DOCK_C_lobe_C.
DR   InterPro; IPR027357; DOCKER_dom.
DR   InterPro; IPR046769; DOCKER_Lobe_A.
DR   InterPro; IPR046770; DOCKER_Lobe_B.
DR   InterPro; IPR046773; DOCKER_Lobe_C.
DR   PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR   PANTHER; PTHR23317:SF74; DEDICATOR OF CYTOKINESIS PROTEIN 8; 1.
DR   Pfam; PF06920; DHR-2_Lobe_A; 1.
DR   Pfam; PF20422; DHR-2_Lobe_B; 1.
DR   Pfam; PF20421; DHR-2_Lobe_C; 1.
DR   Pfam; PF14429; DOCK-C2; 1.
DR   Pfam; PF11878; DOCK_C-D_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS51650; C2_DOCK; 1.
DR   PROSITE; PS51651; DOCKER; 1.
PE   3: Inferred from homology;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          525..696
FT                   /note="C2 DOCK-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51650"
FT   DOMAIN          1593..2027
FT                   /note="DOCKER"
FT                   /evidence="ECO:0000259|PROSITE:PS51651"
FT   REGION          892..922
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        893..921
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2053 AA;  233910 MW;  75D0CBC6FAAC68C5 CRC64;
     MFYGHYRHSS AEIRRNFSGN LAAYHTRTNS NTSPTTYLIP QSYEAVEPLD LEEFLMSQLR
     SEDLALMQEL GDFPDDDLKV EQVEKECRTV RHSVPEEGGE LDPHVRDCLK SYTQPWLVVS
     RRCQGDGWST YSERVGLHKV LQKQVFETDV KSPTLEGLTD DSGRTLTSSD FNLRCLAPDQ
     RLDGLMAFSS PEELDRLNQQ ARNGNRHPEL FALYPPPDEE DSVEIRPIPD CPKEHVGERV
     LIRCQSIKFE IEIEPIFATM ALYDLKEKKK ISENFYCDLN SEQFKHFLKP HTPHVDVSTL
     AKSAIFSITY PSPDIFLVVK IEKVLQQGEI SDCADPYMTL KESESKNKDK IEKLRNQAEA
     FCQRLGRYRM PFAWATVNIM DVINSAIYVP ELDSTKGGKS SSIDRKLQLP RRNSERYTCI
     EEQFCQVGGF KPASITISTI FKQEGDRLSD EDLLKFLSDI KKTSRIKTIP GTIKLDIAPV
     NDMPQACLSP ELIPLKPLAE KNIRPVKEVL EFPSNEVYVP HNIYRNLLYV YPLRLNFVSR
     LTSSKNITIK IQFMSGEDPS SALSVFFGKS SGPEFLKEVY TPITYHNKSP DFYEEVKLSL
     PARLTERHHL LFTFYHISCQ QKQNQSGSCE TLIGFSWLPM LNSDRLQTGQ FCLPIILERL
     PINYSLHPPE KLPPQVPPVK WMEGHKGLFN LEVQAVSSVH TQDNHLERFF TLCHALEGGA
     VFPLRVKEEK IPENKLEHEL KLSIISLSSS SLEPLVLFLH RVLDKLFTLI MQPMVIAGQT
     ANFAQIAFES VVSIVNSLHN SPELVKDQQG RNSLLATYLY WVFCLPDPPQ NMQSSGMVTS
     AAESRYSTMG RATAATVGSM LLQSRVRSSS NPDIPGPHNS AEDAEVKNIL SSKGHNIPGS
     RMSTYGDINN HQNPTGSTRP SNRKQFHEEL ALQMVVSTGV CKENAYKYAW FFFELLVKSM
     AQHVCQMEKH SVPRRSRFSD RFKDDITTIV SVVTAEICTI LVKQHKEVEQ AEKVNISLAF
     FLYDLMSLMD RGFVFQLVKN YCNQMSAKSV SMPTLISMRL EFLRILCSHE HYLNLSVFFS
     SPASAPVSPS PSISSQSSGS CSFQEQQRIL ALFDLSYEFK QQHYLTGLLL TELSEALGME
     GKVQRKAINA INSLLCCHDL DIRCEKPEIR AKVAALYLPL VGIIIEATSN LDFTVSDTRS
     GKNKTGDSED DLENVPPINQ SIAMAIAGNP FNTLGGVCLS LQQGKSIATL AADSSRHLLV
     CFLWVMKNAD RNLVQRWAVE MPPSQLNKLL ELLAICVSCF EYRGKQSSDK VSTQALQKSQ
     QAKLQLEEAL LRGIGARGEM MKRVGGMDRT VGQRENLRWN KDRTQWRQTT DKHDKTKAEL
     DQEALISGNL ATEANLILLD ILETIIQAVP LAECKDSVVG GVLKVLLHSI TCNQSTTYLS
     HTFSTLRALV VKFGDLLFEE EAEQCADLCQ KVLQYCSSPV DENRSQACAT LYLIMRYSYS
     NASNFSRIKM QVTMSLASLV GKSSDFQEEY LRRSLRTILA YAEEDAEMQT TQLPAQVDEL
     LRNLNCILSD TVKMREFQED PEMLMDLMYR IAKGYQTSPD LRLTWLQNMA EKHNNRKCYT
     EAAMCLVHAA ALVAEYLSML EDHKYLPVGS VTFQNISPNV LEESAVSDDI LSPDEDGVCS
     GRCFTENGLV GLLEQAAELF STGGLYEAVN EVYKIIIPIL EARRDFRKLA FTHDKLQRAF
     ENIINKGLKR MFGTYFRVGF YGSKFGDLDE REFIYKEPGI THLPEISHRL ENFYSQCFGE
     DTLVMIKDST PVDRKQLKPN KAYIQITYVE PYFDDYEMKD RLTNFEKNFN LRRFMYTTPF
     TKSGRPRGEL NEQYKRKTIL TTMHAFPYVK TRINVIQKEE FDLTPIEVAI EDMQKKTREL
     AVATHREQPD AKMLQMLLQG SVGATVNQGP LEVAQVFLNE IPADPKLFRH HNKLRLCFKE
     FIMRCGEAVE KNKHLITSDQ KEYQQELKKN YNRLRENLRP MMERKIPELY KPIIRPRESF
     KRLSFRRAQE ENS
//