ID A0A3B3E015_ORYME Unreviewed; 927 AA.
AC A0A3B3E015;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000035049.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000035049.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR AlphaFoldDB; A0A3B3E015; -.
DR Ensembl; ENSOMET00000029616.1; ENSOMEP00000035049.1; ENSOMEG00000022126.1.
DR GeneTree; ENSGT00950000182815; -.
DR OMA; CMQNKRF; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd08802; Death_UNC5B; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR042156; Death_UNC5B.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF6; NETRIN RECEPTOR UNC5B; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 1.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT TRANSMEM 368..392
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 172..253
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 527..667
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 859..925
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 414..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 927 AA; 102205 MW; 1BC1C97773575A70 CRC64;
MLAQKHRFHL KPSVPSRRRK TGFREIGCLS LLQCNCSSDD GVTEGLPDSY PSAPAEPLPV
FLLEPEDAFI VKNRPVQLRC RASPATQIYF KCNGEWVNQN DHVTRESLDQ ITGLVVREVD
ISVSRTQVEE LFGLEDYWCQ CVAWSSAGTT KSIRAYVRIA YLRKNFEQEP LGREVRLEQE
VLLQCRPPEG MPAAEVDWLK NEDVIDPSKD SNFLITIDHN LIIKQARLSD TANYTCVARN
VVAKRRSSTA TVIVYVSGGW SSWTEWSECN ARCGRGWQRR TRSCTNPTPL NGGAFCDGPP
VQRVTCTTLC PVDGGWTEWA KWSACGTECT HWRSRECQAP PPINGGKHCS GSMMESKNCT
EGLCMGEAVY AGLVVALLLS VVMVLCVGVL AYRRRCRHLH GDITDSSSAL TAAFHPGNYK
PPRQDNPRPL HPSAPPDLTA TAGTFRGPLF SLQQAVHDSP HKIPMTTSPL LDPLPSLKIK
VYNSSTLSSL ELPTDSGDGE ILSLKSVGTV GREREYHCHT LSREPGLSTS ATLGNLGGRL
TIPSTGVSLL VPPGTIPQGK FYEMYLIINK SPSEGSQTVL SPVVSCGPSG MLLSRPVVLT
LPHCAQLDTP TPDWTLTLKT QTHQGGWEEV LTVGEETLSS PCYLQLEEEC CHVLLEQLGT
YGLVGQSCPP QPACKRLQLA LFAPRAPCLS LDLSLRIYCI HDTPHALKEV MDLERSLGGV
LLEDPKPLLF KDSYHNLRLS IHDIPHSHWR SKLLAKYQEI PFYHIWSGSQ RPLHCTFSLE
RSSLAVSQLT CKICVRQVEG EGQIFQLLTD IQETLPPHSP IPSGGSCLPS SQVGPYAFRL
PDSIRQKICT SLDAPSARGC DWRLLARSLG FDRYLNYFAT KPSPTGVLLD LWEACHQGDA
DLVSLATALE EMGKSEVLVV MTTDGDC
//
