ID A0A3B3E0S3_ORYME Unreviewed; 268 AA.
AC A0A3B3E0S3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=E3 ubiquitin-protein ligase RNF170 {ECO:0000256|ARBA:ARBA00014068};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
DE AltName: Full=RING finger protein 170 {ECO:0000256|ARBA:ARBA00031107};
DE AltName: Full=RING-type E3 ubiquitin transferase RNF170 {ECO:0000256|ARBA:ARBA00030110};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000035210.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000035210.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 30732.ENSOMEP00000035210; -.
DR PaxDb; 30732-ENSOMEP00000035210; -.
DR Ensembl; ENSOMET00000029908.1; ENSOMEP00000020449.1; ENSOMEG00000022333.1.
DR Ensembl; ENSOMET00000029923.1; ENSOMEP00000020457.1; ENSOMEG00000022333.1.
DR Ensembl; ENSOMET00000029937.1; ENSOMEP00000035210.1; ENSOMEG00000022333.1.
DR GeneTree; ENSGT00390000017123; -.
DR OMA; TIRPEYR; -.
DR OrthoDB; 154493at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd16553; RING-HC_RNF170; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR010652; DUF1232.
DR InterPro; IPR038896; RNF170.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR22894:SF1; E3 UBIQUITIN-PROTEIN LIGASE RNF170; 1.
DR PANTHER; PTHR22894; UNCHARACTERIZED; 1.
DR Pfam; PF06803; DUF1232; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 27..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 90..133
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 268 AA; 30876 MW; B026C6FCCED9FAA9 CRC64;
MEDSQCGELD YLIQDEDTII EGVSNQVLFV VVLSLTFLAG LLTLLCRQDE QNIHPENQEH
VRAVRQQLQT EQDENPQAEA RQQFYTDMSC PVCLQQAVLP VETNCGHLFC GSCIIAYWRY
GTWLGAIHCP ICRQMVTLLF PLFHEHAAPQ RVQDGEAQPQ LILRDLNDYN RRFSGQPRSL
MDRLRDVPTL LRHAFREMFS VGGLFWMFRI RILLCLVGAI TYLASPLDIL PEALFGLLGF
MDDFFVILLL FVYISIMYRE VVTQRLNG
//