ID A0A3B3E2W3_ORYME Unreviewed; 1257 AA.
AC A0A3B3E2W3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Ras-specific guanine nucleotide-releasing factor 1 {ECO:0000313|Ensembl:ENSOMEP00000036045.1};
GN Name=RASGRF1 {ECO:0000313|Ensembl:ENSOMEP00000036045.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000036045.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000036045.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3E2W3; -.
DR STRING; 30732.ENSOMEP00000036045; -.
DR PaxDb; 30732-ENSOMEP00000036045; -.
DR Ensembl; ENSOMET00000031427.1; ENSOMEP00000036045.1; ENSOMEG00000023646.1.
DR GeneTree; ENSGT00940000157599; -.
DR OMA; SCNTNGY; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd13261; PH_RasGRF1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF193; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 1; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 22..129
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 240..426
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 467..586
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 633..748
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1022..1254
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 711..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 150..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 799..829
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..852
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1257 AA; 143140 MW; D92B8EECF9238799 CRC64;
MQKGIRLNDG HVTYLGLLAK KDGTRRGCLS KKSSDNTKWH TKWFALLQNM LFYFENESSS
RPSGLYLLEG CMCDRAPSPK PSLSAKECLE KQYYFTVSFT HENQKALELR TEDVKDCDEW
VAAISHASYR NLATEHETLM QKYLHLLQIV ETEKTVAKQL RQQIEDGEIE IERLKSEIAG
LLKDNEKINT SPAAAPSDDD SEIKKIKKVQ SFLRGWICRR KWKTIIQDYI RSPHAESMRK
RNQVVFSMLD SEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH
QIFYQGLKAR IASWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC KQNRDFDKLL
KQYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP HEHIERNSLD YAKSKLEELS
RIMHDEVSET ENIRKNLAIE RMIIEGCEVL LDTSQTFVRQ GSLIQVPMSE KGKITRGRLG
SLSLKKEGER QCFLFSKHLI ICTRGSGAKL HLTKNGVVSL IDCTLMEEPE GTDDESKSDK
SGQDMEHLDF KIVVEPKDSQ SFTVILVASS RQEKSAWTSD ISQCIDNIRC NGLMMNAFED
NSKVTVPQMI KSDSSLYCDD VDIRFSKMMN SCKVLQIRYA SVERLLERLT DLRFLSIDFL
NTFLHSYRVF TTADVVLDKL ITIYKKPISA IPARSLELFF ASNQNSKLLY GEPPGSPRAS
RKFSSPPPLA IAKNSSPNRR RKLSLNIPII TGGKALDLAA LSCSSNGYAS MYSTMSPFSK
TTLDINKLYV SSPIASKISD EGEDKKEKVE DASVCKQADL SVREESDNDQ NQSDDGDAEA
SPTKSPTTPK NIKCKNSSEF SLFSYNNGMV MPSCRELDNN RSALSAASAF AIATAGANEG
TPTKEKYRRM SLASTGFPTD QRNGDKEFVI RRAATNRVLN VLRHWVSKHA QDFESNNELK
TKVIAFLEEV MHDPELLTQE RKAAANIIRT LTQEDHGDNQ ITTEDVTQLV GGGKAEPFES
HSALEIAEQL TLLDHLVFKV IPYEEFFGLG WMKNDKNEKT PYIMRTTKHF NDMSDLIATE
ILRSEDVVTR VSVIEKWVAV ADICRCLHNY NAVLEITSSL NRSSVFRLKK TWLKVSKQTK
ALIDKLQKLV SSDGRFKNLR EALKNCDPPC VPYLGMYLSD LAFIEEGTPN YTEDNLVNFS
KMRMISHIIR EIRQFQQTAY KIDLQPKVAQ YLLDKSSALD EESMYKASLR IEPKVPN
//
