ID   A0A3B3E311_ORYME        Unreviewed;       997 AA.
AC   A0A3B3E311;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Inter-alpha-trypsin inhibitor heavy chain 5 {ECO:0000313|Ensembl:ENSOMEP00000036120.1};
GN   Name=ITIH5 {ECO:0000313|Ensembl:ENSOMEP00000036120.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000036120.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000036120.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the ITIH family.
CC       {ECO:0000256|ARBA:ARBA00010158}.
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DR   AlphaFoldDB; A0A3B3E311; -.
DR   STRING; 30732.ENSOMEP00000036120; -.
DR   PaxDb; 30732-ENSOMEP00000036120; -.
DR   Ensembl; ENSOMET00000031513.1; ENSOMEP00000036120.1; ENSOMEG00000023705.1.
DR   GeneTree; ENSGT00940000158317; -.
DR   OMA; AKKFIYT; -.
DR   OrthoDB; 608326at2759; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR010600; ITI_HC_C.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR10338:SF62; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H5; 1.
DR   Pfam; PF06668; ITI_HC_C; 1.
DR   Pfam; PF08487; VIT; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00609; VIT; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..997
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017299370"
FT   DOMAIN          54..181
FT                   /note="VIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51468"
FT   DOMAIN          322..506
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          133..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          230..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          682..723
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   997 AA;  109006 MW;  BDAAB98B8A0EDDA7 CRC64;
     MTSARARRKM LPLLVLLLSA LSRTEQLQSE LDSEDLEDLD LDLNLDLDLA PRRVPRQVKT
     ILAKETKPHI QELSIKTTII SRYAFTAVHC AMLNRHVAAA EGVFQFQIPA DAFISNFTMI
     VGGRVYQSEV TAKERKVKQG NGKAKSQESG ENSPEPEVEV FRMAVNIPGR NRAVFLLTYE
     QLLQRRLGRY QHVTSLRPLQ LVSRLSLDVT VVDHAPITDL EVLPLQSGRT SSSASSASAG
     SNAAAKPELP ITTEIKQQQN VWRITFSPNI VQQARISTSG VLGDFVIRYD VQRELGIGDI
     QVLDGHFVHY FAPKDLPAVP KNVVFVIDTS ASMLGAKMRQ TKDALFTILK DLRPGDHFNF
     ISFSNKVKVW QPNRLVPVTP LNIRDAKKFI LLLMPTGGTN IDGAIQTSSS VLRDYLSGSD
     SGPNSVSLII FLTDGRPTTG EVQSATILGN TRSAVQEKFC IFTIGIGNDV DYRLLERMAL
     DNCGMMRRIP EEADASAMLK GFYDEIGTPL LSDIRINYTE STVGYVTQNL FTNYFNGSEI
     VIAGKLTNSS AESLHVQVTA SNNDKSIVLE TDVPLQHRQL ETRRHVKEAT AAVAAGAKAP
     ASGSLSGLGL PLGSIAEHFA ERVWGFLSVK EGLRSRLRST TSREREDHIQ QATNLSLTYH
     FLTPLTNMVV EKPVVLADGT MEPASTAAPG GGEAPPAAND LPGEADGETE HEPLRRLGSQ
     TAPLTNVLGK DKRRPAKKPI TISKTSADGD PHFVVEFPLS KLTVCFNING EPGHVLRLVS
     DHKHSGVTAN GKLVGAPAPP GSHKQQRTYF SSITIVVDRP RRAYIEVTPR KVILDGRDRI
     VLPCHSSAAV DSGVLSVAIV GKANVTVTIG GNISFVILLH HYKNPAPYQT DHLGFYIGNS
     KGLSANCHGL LGQFLHQEVG LAELPVEVGA QPSTVLKVKD RSVPVVHKSR RIYSGTQSVD
     CWFARNNAAK LIDGRYEDYV APHMFDTGDS PQRTNRM
//