ID A0A3B3H292_ORYLA Unreviewed; 259 AA.
AC A0A3B3H292;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Metaxin 2 {ECO:0000313|Ensembl:ENSORLP00000025946.1};
GN Name=mtx2 {ECO:0000313|Ensembl:ENSORLP00000025946.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000025946.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000025946.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000025946.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000025946.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000025946.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004294}.
CC -!- SIMILARITY: Belongs to the metaxin family.
CC {ECO:0000256|ARBA:ARBA00009170}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3B3H292; -.
DR STRING; 8090.ENSORLP00000025946; -.
DR Ensembl; ENSORLT00000046701.1; ENSORLP00000025946.1; ENSORLG00000001332.2.
DR GeneTree; ENSGT00950000182919; -.
DR InParanoid; A0A3B3H292; -.
DR Proteomes; UP000001038; Chromosome 15.
DR Bgee; ENSORLG00000001332; Expressed in animal zygote and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0001401; C:SAM complex; IBA:GO_Central.
DR GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd03211; GST_C_Metaxin2; 1.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR019564; Sam37/metaxin_N.
DR PANTHER; PTHR12289; METAXIN RELATED; 1.
DR PANTHER; PTHR12289:SF38; METAXIN-2; 1.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF10568; Tom37; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG01180; SUF1; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 45..162
FT /note="Mitochondrial outer membrane transport complex
FT Sam37/metaxin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10568"
FT DOMAIN 188..249
FT /note="Metaxin glutathione S-transferase"
FT /evidence="ECO:0000259|Pfam:PF17171"
SQ SEQUENCE 259 AA; 29659 MW; 7271DBF38CEE98C1 CRC64;
MIRVNERVLL CLSLTAAEPW PENATLYQPL KGEGFFSSSC SLYHLQTYLR MCGLPVQVVC
RPNAEYMSPS GKIPFIHVGN QVVSELGPIV QFSKAKGHSL SDGLDDVQRA EMKAYMELVN
NMLLTAELFI QWCDETTVSQ ITRHRYGTPY SWPLNLILAY QKQWEVRRKM NAVGWGGKTV
DQVYEDVSQC CQALSQRLGT QPYFFKIPTE LDALVFGHLF TILTTQLTNT ELLERVRSYS
NLLSFCRRIE QTYFESKDS
//
