ID A0A3B3H2L6_ORYLA Unreviewed; 1355 AA.
AC A0A3B3H2L6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=DNA repair protein REV1 {ECO:0000256|ARBA:ARBA00020399};
GN Name=rev1 {ECO:0000313|Ensembl:ENSORLP00000026020.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000026020.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000026020.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000026020.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000026020.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000026020.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945}.
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DR Ensembl; ENSORLT00000045536.1; ENSORLP00000026020.1; ENSORLG00000012211.2.
DR GeneTree; ENSGT00940000156374; -.
DR Proteomes; UP000001038; Chromosome 21.
DR Bgee; ENSORLG00000012211; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:InterPro.
DR GO; GO:0042276; P:error-prone translesion synthesis; IEA:InterPro.
DR CDD; cd17719; BRCT_Rev1; 1.
DR CDD; cd01701; PolY_Rev1; 1.
DR CDD; cd12145; Rev1_C; 1.
DR CDD; cd19318; Rev1_UBM2; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 6.10.250.1630; -; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR Gene3D; 1.20.58.1280; DNA repair protein Rev1, C-terminal domain; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR025527; HUWE1/Rev1_UBM.
DR InterPro; IPR012112; REV1.
DR InterPro; IPR031991; Rev1_C.
DR InterPro; IPR038401; Rev1_C_sf.
DR InterPro; IPR047346; Rev1_UBM1/2.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR45990; DNA REPAIR PROTEIN REV1; 1.
DR PANTHER; PTHR45990:SF1; DNA REPAIR PROTEIN REV1; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF00817; IMS; 2.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF21704; POLH-Rev1_HhH; 1.
DR Pfam; PF16727; REV1_C; 1.
DR Pfam; PF14377; UBM; 2.
DR PIRSF; PIRSF036573; REV1; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 59..146
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 556..796
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT REGION 236..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 996..1042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1068..1110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1195..1243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..538
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..624
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 996..1028
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1207..1221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1355 AA; 149435 MW; 8A5646D35741E58B CRC64;
MMAFFRWLSM SRDGWMRKRA SAGDDNGWAE RGGYMAAKVS KLDEQFRLDA PREKQKEGAC
SGIFRGVAIY VNGYTEPSAD ELRRLMMLHG GQFHVYYSRS KTTHIIANNL PNCKIQDLKG
EKVIRPEWIT DSIKAGHLLP HLKYQLYAKQ KSTLFPGITL HQTLEVAGTS QSSLQPNVRQ
KLHLPQQKIG LSVPHTGPSL LSCRNNHIPP SSCSSPQPTQ HSIGHSIVGQ IITDSKHRGP
LQSHPPQNLN HTKPPHKSTH RKEEEKIAIN GILPTSSDVM SHSKTNKMQE CVKGGPCLPA
ASNMAKEVPL TNGHAHLLNG ALRPEDLEPL IDHHGSNQPK HRARSSPEKP QSPVEQARSD
PYEFPLSPPK QSQMSPVVLD QSSTEGASGC PHTPPTNHDT AKDSETQLFT ELHQPSPQVS
TGSEQNHLSQ PPFSHSHSLL RPNGSHHNAF SCNPALSSPA GVKTKLNLHS DPSSKSSVQL
LEQTGSLISE FYSHSRLHQI STWRIGFSEY INELHHKKKE SGSISYPGKD RLRKAAAQRP
SDSRGSSAPV SVKSCIFHVD MDCFFVSVGI RHRPDLKGKP VAVTSNRGHG RVPTRPGANP
QVEQQYYQRK HAHPQPEKEG DLLHTSPSQD SPDSYANGVN LDSAALSMAE IASCSYEARQ
AGVRNGMFFG KAKQLCPSLQ SVPYDFEAYK EVAINMYEIL ASYTRDIEAL SCDEALIDGS
ALLAELGISP DDLAQAIRAD IKEKTGCSAS VGMGSNILLA RLATRKAKPN GQYFLKSEEV
DDFIRDLPVT RLPGVGHVMG KKLATLGVTT CGDLQQVSLS QLQRMFGPRT GQTLFRFCRG
LDDRPVRCEK ERKSVSAEMN YNIRFTKVEE AESFLSNLSM EVQKRLREAG LRGRRVTLKV
MVRKVGAPLE SAKYGGHGIC DNLARTVMLT QPTDSGQLIA SAVIKLLHAM QLQVQDLRGI
GIQVQLLEGN RHLPPDGRGP RSCSIKEMLT IRSNKNNYCK EQSTPSASTS SLISSPAEPV
PGTSKEQPTC RKTPKHSRTR LSITIEVPSP SQVDRSVLEA LPPELREQVE QSWTKRDGIP
NKCHSPALQQ SSPHPRQASP PRPALSSPPA GTLVLQIPNQ PNTPGIVLEL PNFSQVDPDV
FAALPKELQE ELKSAYNRAA NVQAQLKTVE QKNPLLQLKQ PAVGTGIGRV KRRYKRKNAV
SPLKKGTSPM KRQQTNSPVK PIAAAGKSRE PINIPKNENN PSTSNLDLAE PAVEAVSSPV
PMLAGAFDLT DIRTLLREWV TTITEPMEED ILQVVKYCTE LIEDKDLEKL DLIIKYMKRL
MQQSVESVWS MAFDFILDNV QVILQQAYGS ILKIT
//
