ID A0A3B3H3G5_ORYLA Unreviewed; 757 AA.
AC A0A3B3H3G5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Mitofusin 2 {ECO:0000313|Ensembl:ENSORLP00000026370.1};
GN Name=mfn2 {ECO:0000313|Ensembl:ENSORLP00000026370.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000026370.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000026370.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000026370.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000026370.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000026370.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004374}.
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DR AlphaFoldDB; A0A3B3H3G5; -.
DR STRING; 8090.ENSORLP00000026370; -.
DR Ensembl; ENSORLT00000037233.1; ENSORLP00000026370.1; ENSORLG00000025366.1.
DR GeneTree; ENSGT00390000013727; -.
DR InParanoid; A0A3B3H3G5; -.
DR OrthoDB; 3282693at2759; -.
DR Proteomes; UP000001038; Chromosome 7.
DR Bgee; ENSORLG00000025366; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0008053; P:mitochondrial fusion; IBA:GO_Central.
DR GO; GO:0051646; P:mitochondrion localization; IBA:GO_Central.
DR CDD; cd09912; DLP_2; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR006884; Fzo/mitofusin_HR2.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR027094; Mitofusin_fam.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10465:SF1; MITOFUSIN-2; 1.
DR PANTHER; PTHR10465; TRANSMEMBRANE GTPASE FZO1; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF04799; Fzo_mitofusin; 1.
DR SUPFAM; SSF111479; Fzo-like conserved region; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 629..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 93..342
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT COILED 700..737
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 757 AA; 85795 MW; ED7023FACE17DDEF CRC64;
MSVAFPRVSP APFHCKEKRT MAEVNASPLK HFVTAKKKIN GIFEQLGAYI RESASFLEDA
HRNEDLDPVT AEEQVQEVRG FLSKVAGIGE VLARRHMKVV FFGRTSNGKS TVINAMLCDK
VLPSGIGHTT NCFLRVEGTD GSEGFLLTEG SEEKKSIKTV NQLAHALHQD QDLDAGSLVC
VMWPKVKCAL LRDDLVLVDS PGIDVTTELD SWIDKFCLDA DVFVLVANSE STLMQTEKSF
FHKVNERLSS PNIFILNNRW DASASEPEYM DEVRRQHMDR CSNFLVEELG VVDRAQASDR
IFFVSAKEVL QARMQRVQGM PEAGGALAEG FQARMFEFQN FERRFEECIS QSAVKTKFEQ
HTVRAKQISE ALRRIMDSVH VAAQEQRVYC LETKEDRQDR LEFIDKQLDL LTTDCKSKIK
KITEEVERQV SNAMAEEIRK LYVLVDDFHM DFHPSAVVLK VYKNELHRHI EEGLGKNMSE
RCSSSISSAL QATQADMIEG LKPLLPSTLR DQVEKMVPRQ CFSLTYDLAC DKLCSDFQED
ISFHFSLGWT MLVNRFLGPK NTRRALMGYS DQVPRPMALT PVSSSMPPFP QSAMTQEELM
VSMVTGLASL TSRTSMGVLV VGGVIWKAVG WRLIALSLGL YGLLYVYERL TWTTKAKERA
FKRQFVDYAS EKLQLIVSYT GSNCSHQVQQ ELAGVFAQLC QQVDITRQNL EDEIQDMNSK
IELLDNLQSR AKLLRNKAGW LDSELNMFTQ QYLQHSK
//
