ID A0A3B3H4T7_ORYLA Unreviewed; 758 AA.
AC A0A3B3H4T7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=NACHT LRR and PYD domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000026887.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000026887.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000026887.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000026887.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000026887.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3H4T7; -.
DR STRING; 8090.ENSORLP00000026887; -.
DR Ensembl; ENSORLT00000041329.1; ENSORLP00000026887.1; ENSORLG00000030311.1.
DR GeneTree; ENSGT01070000253760; -.
DR InParanoid; A0A3B3H4T7; -.
DR Proteomes; UP000001038; Chromosome 19.
DR Bgee; ENSORLG00000030311; Expressed in heart and 13 other cell types or tissues.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF13516; LRR_6; 6.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 12.
DR SUPFAM; SSF52047; RNI-like; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 68..127
FT /note="NOD2 winged helix"
FT /evidence="ECO:0000259|Pfam:PF17779"
FT DOMAIN 129..250
FT /note="NACHT LRR and PYD"
FT /evidence="ECO:0000259|Pfam:PF17776"
SQ SEQUENCE 758 AA; 84627 MW; B01BE179358680A1 CRC64;
MCEVPVFCWI TAVVLEHILT TEQIGELPTT LTDMYSHFLI VQTKRKKNKY QQEHEKGPQE
LIEGDNEVLL KLGKLAFDNL EKGNIMFYQE DLEQCGLDVT EASVYSGVCT EIFRRECEIF
QKPVYSFVHL SVQEFLAAVY MFHCYVKRNK EVIEGFMKYD VNSLALDEFL SRVMEKSLQS
RTGHLDLFVR FLHGLSMDSN QKILGSLLGR TSKNQKNVQA VIQRMKKISV KMSPDRGINI
FHCLMEMKDR LVHQEIQQFL KSENQSEKKL SDIHCSALAY MLQMSEEVLD ELDLNRYNAT
PDGRRRLIPA VRNCRKAWLS GCGLSETHVE VVASALKSNL GHLTELDLSK NKVKDMGMEA
LSAGLERSNC KLETLSLSEL TCAALSSALK SNPSHLTELD LSKNMLQDVG VEHLSWFLQN
PDCRLKTLRL MECGLSGLSC AALSSALKSN PSHLTELDLS KNMLQDVGVE HLSGFLHNPD
CRLKTLSYGK GLVECELSEI SCAVLASALR SNPFHLKDLD LGCNSLQDSG VQQLASFLQS
PDCTLNALRL DICSFSEYGC AALASALTIS PSHLLELDLS CNKNLKDAGL QHLCTYLQHC
GCRLKKLRSD CFCTYCSPPL LMAECGLSEM SCAALDSALK SNPSYLEELD LTMNSLKDAG
LEQLFGILKN PHCGLKTLNV ESCGLTEISC TALLSALKSN PSHLAFLDLS RNDLKASQVK
KLEDLLKNPH YKLETLRSVQ ALTHSDNFSM LNLSRSNS
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