ID A0A3B3H559_ORYLA Unreviewed; 1440 AA.
AC A0A3B3H559;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000026342.1};
GN Name=LOC110015202 {ECO:0000313|Ensembl:ENSORLP00000026342.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000026342.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000026342.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000026342.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000026342.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000026342.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
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DR Ensembl; ENSORLT00000031541.1; ENSORLP00000026342.1; ENSORLG00000022515.1.
DR GeneTree; ENSGT01060000248608; -.
DR InParanoid; A0A3B3H559; -.
DR Proteomes; UP000001038; Chromosome 6.
DR Bgee; ENSORLG00000022515; Expressed in mesonephros and 7 other cell types or tissues.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00303; retropepsin_like; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR Gene3D; 3.10.20.370; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR001995; Peptidase_A2_cat.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR005162; Retrotrans_gag_dom.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR24559:SF437; RIBONUCLEASE H; 1.
DR PANTHER; PTHR24559; TRANSPOSON TY3-I GAG-POL POLYPROTEIN; 1.
DR Pfam; PF13650; Asp_protease_2; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF03732; Retrotrans_gag; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00298; CHROMO; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50175; ASP_PROT_RETROV; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 311..325
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 368..407
FT /note="Peptidase A2"
FT /evidence="ECO:0000259|PROSITE:PS50175"
FT DOMAIN 560..739
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1077..1236
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 1378..1436
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 257..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1440 AA; 161803 MW; 1241694AC1765731 CRC64;
MTERTGQTPD PADPEGLQHA LSIQENLLTH QAEAITLLSS AQWDLFRRFD SITQFLSAST
SQHANSAAAA QDPDSVNKAT SVSADIPENA RLQPEPSYGN VDAFGGFLLQ CQLIFQQAPR
YYHSDHSKIS LIVNSLRSKA LQWAQAFLAS HPIAHLPYDS FIGEFRLVFD QPRKQEEAVR
RLLSLKQGNR PVSDHLIDFR ILAVEAGWPD SALKGIFYQS LNERIKDHLC SQPEADSFED
LVTAALRSDD RLRERFAEQK RKSPVNPSPP MHAVQPSNRE TLDNVPHEPM QIGHSKLSPE
ERDKRRDEGL CFYCGQAGHM VSDCRARLKL PSPPLDNRPR GGDAELIHSS KFLCVPVKLS
HKNLVFELEA LIDSGAEHSL IDQRLVQELS LPVEPLANPV KAAGLGGKQL TRITKRTGPV
LLLTSGNHRE YLQFFITHCP QTPIILGFSW LQIHNPHIDW SSPRIANWST YCLANCLHSA
LPITNVPDSA QEDIDLSNVP ACYHDLRTVF SKVKASSLPP HRPYDCSIEL LNGAPLPKGK
LYKLSGPEKT AMENYIQEAL SQGHIRPSSS PVGAGFFFVE KKDKTLRPCI DFRELNQITV
KDKYSLPLID SVFESVQQAK IFTKLDLRNA YHLVRIREGD EWKTAFTTPL GHYEYLVMPF
GLTNAPAVFQ RLVNDVLRDF LNRFVFIYLD DILIYSSDSS QHKHHVRLVL ERLLANQLFV
KAEKCEFHVS TVPFLGYIIE AGNIRPDPAK IEAVAQWEIP QTRKKLQQFL GFANFYRRFI
RNYSSIAAPL TQLTSINKTY YWNPAADSAF KKLKSLFVSA PILIQPDVTK QFIVEVDASD
SGVGAVLSQR EESSGKLKPC AFFSRKLSQA EQNYDVGNRE LLAIKLALEE WRHWLEGAEK
PFIVWTDHKN LAYLRSAKRL NSRQARWCLF FDRFHFTISY RPGSRNVKPD ALSRKYSSSD
SSSDSSILPM SCFVGSLTWE IESKVQQAQG EIPAGTSCPS GTLYVPESLR SEVIAWGHTS
RIACHGGVYR TIRLLKRRFF WPSLERDVRE YISACSICAR SKASNRPPSG HLLPLSTPSR
PWSHIAVDFV TGLPPSQGHT VILTVIDRFS KAAQFIPLPQ LPSAMETADA LIHHVFRHHG
IPSDIVSDRG PQFTSQVWKA FCSALGATVS LTSGYHPQAN GQAERANQEL EAALRCLAAQ
NQEDWSKYLV WVEYAHNSHS STATGISPFE ASLGYSPPLF PSQELDLAVP SVQLHLQRCR
DIWLQTRAAL LRTKESNCQI ANRRRVVSPN YQPGQKVWLS SRNIPLQASS RKLAPKFIGP
YTIDRVINPV CVKLRLPAAL KVNPTFHVSQ VKPVTESPLC PPSASPPPAR TIDGAPAFTV
DRILDVRRRG RGVQFLVDWE GYGPEERSWI SRSLILDHTL IDDFYRAHPD RRLGPPGGGR
//
