ID A0A3B3H573_ORYLA Unreviewed; 1688 AA.
AC A0A3B3H573;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=SH3 and multiple ankyrin repeat domains 3b {ECO:0008006|Google:ProtNLM};
GN Name=shank3b {ECO:0000313|Ensembl:ENSORLP00000027084.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000027084.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000027084.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000027084.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000027084.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000027084.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Postsynaptic density
CC {ECO:0000256|ARBA:ARBA00034105}.
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DR Ensembl; ENSORLT00000037046.1; ENSORLP00000027084.1; ENSORLG00000024534.1.
DR GeneTree; ENSGT00940000153561; -.
DR Proteomes; UP000001038; Chromosome 23.
DR Bgee; ENSORLG00000024534; Expressed in heart and 11 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd09506; SAM_Shank1_2_3; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24135; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24135:SF29; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 3 ISOFORM X2; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT REPEAT 184..216
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 251..283
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 284..316
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 449..508
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 549..643
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1623..1686
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 350..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 904..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1011..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1469..1494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1506..1557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1581..1602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..784
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..800
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..859
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..921
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1249..1265
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1282..1298
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1299..1318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1366..1399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1406..1420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1524..1540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1688 AA; 183309 MW; 437546F094ED93DB CRC64;
MIAHGNRRLL TATRQALLSP GTTTGMTRPL ETASWSASAS QTYSRRSVCG WTQSYQFGPP
AFNGRAGKFL DEERLLKEYP LPPITPIPYL EFRYKRRVYT QTYVDDKQLA KLHTKANLKR
FMEHVHQKNV EKVSKWLEKG LDPNFHDSDS GECPLTLAVQ LEDSCDLIKV LRSGGAHLDF
RTRDGITALH RAVLCRNSTA LMTLLDLGAS PDYKDSRGLT PLYHSAMVGG APYCCELLLQ
DHASIGITDE NGWQEIHQAC RYGNVQHLEH LLFYGADMSS QNASGNTALH LCALYNQDGC
ARVLLFRGAN KDIKNYNNQT AFQVAIIAGN FDLAETIKIH KSSDVVPFRE TPSYTKRRRA
GAPKTPAGNG LSSPRSLIRS ASDNALESPA SSPGPSLQSL ETHHDTHTHS LRRHTRRLSP
GGAGHVENSP PSSPPITPQM RKRRLYSAVP GRTFIATRSH VPQGPGEIQL HRGERVKVLS
IGEGGFWEGT VKGRTGWFPA DCVEEVQMRQ FDPRLETRED RTKRLFRHYT VGSYDNYTSY
SDYVIEEKIA VLQKRESEGF GFVLRGAKAE TPIEEFAPTP AFPALQYLES VDQGGVAWRA
GLRTGDFLIE VNGTDVVKVG HRQVVSLIRQ GGSRLLMKVV SVSRKSESNL IRKKAPPPPK
RAPSTSLTLR SKSMTADLED IEKLDEMLAG GQQEVVLRGR PTDDFRAATV KQRPTSRRIT
QAEINSLFER QGLVPPSAPE KSTMALPRGM SRTKSFGTPE DDRITALINE SRFPRSSSLT
DSFIPPPPQT APPPPPPASS ISSLYMFDSG PPPSFLPPPP PARGEGLTRS SFKPGAEPRL
QELSDLPARS HAHAERQRKA RSMIILQDTS GPPPALQPDA HVAPGAHALH TPTHTATHTL
RTATHTSTLS LHSTSPSLGH TPLSRRRGRP IENPYANVGQ QAPPTKPQRR KSPLLKQLPV
EEHGLGIKDH DPSKLDGGGP TSPSRAELYQ QQVLSERARV QGRRSSLFLS VEGAGSENQA
PPLLTQSHSM DDLGELPPPA PVLSPSPTPH TFLHPLTGKP LDPSSPLALA LAARERALTA
RTPSPEPRTK HASASTTPIP TPAASPEGRH RRTPMTTPQS SPEPRSKRST PQMSPEQRAK
RTTPQTSPEL RHKRMTPPLF PDGQVERPET EGGVTSPAAP SPERWRPCPL PALANESHSP
LIDRRRSLTV GSSEEEGGAY TVTLPPALLS SSDEETREEL RRIGLVTPPP AFASPPAPPP
PSSLALLPRR SGEGGGESGP ESLGKRGDEE EAGDEHFHEG STSPSSLPPS ITLASPPAQT
SPSSPPATHP SPSSAATSPS ALKPRLRSPI GRGRSALRDP LLKQSSDSEL LPSVASSSSP
SSPLCSSPTS GSSRQPRYLF QRRSKLWGGG DDERRGFSPD DGGGRPAALG GQASGSAVDL
TSRSASALEL SGRAGSGLDL ANRLQLLNKD SHSLGEEPSP LDPGRRSPVG GARLFSSLGE
LHTISQRGYG ASYTVRPGSR YPVTRRSPSP SPSPSDRSIG LASSPAPERP DLSSGRGLTI
LKSSSLSLPS EPKEVRFVMR SASARTRSRS PSPSPHASPC PSPVLSGPLL ALRPWRQRPL
SLWNKYDVGD WLESMGLAEH RQRFQEHEIE GSHLPALTKE DYIELGVTRL GHRINIERAL
RQLLEGST
//
