ID A0A3B3H703_ORYLA Unreviewed; 989 AA.
AC A0A3B3H703;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Extended synaptotagmin-1 {ECO:0000313|Ensembl:ENSORLP00000027295.1};
GN Name=LOC101173223 {ECO:0000313|Ensembl:ENSORLP00000027295.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000027295.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000027295.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000027295.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000027295.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000027295.1};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}.
CC Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the extended synaptotagmin family.
CC {ECO:0000256|ARBA:ARBA00005867}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3B3H703; -.
DR STRING; 8090.ENSORLP00000027295; -.
DR Ensembl; ENSORLT00000036426.1; ENSORLP00000027295.1; ENSORLG00000007709.2.
DR GeneTree; ENSGT00940000156561; -.
DR InParanoid; A0A3B3H703; -.
DR Proteomes; UP000001038; Chromosome 7.
DR Bgee; ENSORLG00000007709; Expressed in brain and 11 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0005544; F:calcium-dependent phospholipid binding; IBA:GO_Central.
DR GO; GO:0031210; F:phosphatidylcholine binding; IBA:GO_Central.
DR GO; GO:0008429; F:phosphatidylethanolamine binding; IBA:GO_Central.
DR GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR GO; GO:0061817; P:endoplasmic reticulum-plasma membrane tethering; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd08391; C2A_C2C_Synaptotagmin_like; 2.
DR CDD; cd04050; C2B_Synaptotagmin-like; 1.
DR Gene3D; 2.60.40.150; C2 domain; 5.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037733; Ext_Synaptotagmin_C2A.
DR InterPro; IPR037749; Ext_Synaptotagmin_C2B.
DR InterPro; IPR031468; SMP_LBD.
DR InterPro; IPR039010; Synaptotagmin_SMP.
DR PANTHER; PTHR45761:SF3; EXTENDED SYNAPTOTAGMIN-1; 1.
DR PANTHER; PTHR45761; EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C; 1.
DR Pfam; PF00168; C2; 5.
DR Pfam; PF17047; SMP_LBD; 1.
DR SMART; SM00239; C2; 5.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 5.
DR PROSITE; PS50004; C2; 4.
DR PROSITE; PS51847; SMP; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00023055}.
FT TRANSMEM 51..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 102..290
FT /note="SMP-LTD"
FT /evidence="ECO:0000259|PROSITE:PS51847"
FT DOMAIN 289..413
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 414..532
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 573..708
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 868..989
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 555..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 989 AA; 111481 MW; 9C541827CD3F4CB1 CRC64;
LPALTEALLC PTPREQPFTP VVTAPPAERA VGALWSFAKC LGALLPVYLA GYYGFSISLV
LLGLMLYIGW KHGRMEKVMR LKSAMYLLEN EREFTTEKVF RAKRDLPPWV RDTGVIFSLM
QILQQAWPFI GQYLEKLLVE TIAPAIRTSS IHLQTLSFTK VNIGDKALKV VGVKAHTEHD
KKQVMLDLYL SYAGDVEINV EIKKYFCKAG VKGVQLYGKL RVILEPLIGD VPLVGAITMF
FIRRPKLDIN WTGLTNLLDI PGLNSMSDTM IMDAIASHLV LPNRLTIPLV ANLHVAQLRS
PLPRGVVRIH LLEAEDLTAK DTVIKGLIDG KSDPYAVIRV GTQIFTSHHV DSNLNPQWRE
MYEVIVHEVP GQELEVEVFD KDPDQDDFLG RYIHLRLEWL SLLSSADRLS EVIQKNQNLT
TKTSDPPSAA ILAIYLDQGF ELPMRKGSKF PSPMAQISIQ DTTKESKTCY GSNSPVWEEA
FTFFIQDPHK QDIDIQVKDD DHSVPLGSLT IPLNRLLETS DLTLDQWFHL ENSGTASRIY
AKIVLRVSSG SEVGQGGITS DLSPAGPGGL NKPQPTQPQH TTPDPEFATE GVLRIHLVEA
QNLIAKDNFM GGMVKGKSDP YVKIKVAGIT FRSHTIKENL NPVWNELYEV ILTQLPGQEI
QFELFDKDID QDDFLGRCTS IKIKLGHKIW YTLNDVKSGR VHLVLEWLPR VSDLIRLEQV
KLHFSFCSPF IAAICERSTS PRWDEAFHFL VRDPTDETLT VKVREIGWGQ ALGSLTLPLK
EVLSESGLVL DRWLSLDGAL PESQILLRVT LKVNLKRNKC NISVTHEVKL LLSAVLILIN
FFANIEKVQS NHERDIRQLR YVSDNANTAG QVKLTIGYST EENRLFITVH SCRGLAPRSK
DGADPYVSFI LLPDKKATTK RRTTTKRKDL NPEFNERFEF DFSLEESTQR KLYLSVKNSV
SFMSREKELI GKLQLDLDQI DLKAGVAQW
//