GenomeNet

Database: UniProt
Entry: A0A3B3H703_ORYLA
LinkDB: A0A3B3H703_ORYLA
Original site: A0A3B3H703_ORYLA 
ID   A0A3B3H703_ORYLA        Unreviewed;       989 AA.
AC   A0A3B3H703;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Extended synaptotagmin-1 {ECO:0000313|Ensembl:ENSORLP00000027295.1};
GN   Name=LOC101173223 {ECO:0000313|Ensembl:ENSORLP00000027295.1};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000027295.1, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000027295.1, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000027295.1,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000027295.1}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000027295.1};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}.
CC       Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the extended synaptotagmin family.
CC       {ECO:0000256|ARBA:ARBA00005867}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3B3H703; -.
DR   STRING; 8090.ENSORLP00000027295; -.
DR   Ensembl; ENSORLT00000036426.1; ENSORLP00000027295.1; ENSORLG00000007709.2.
DR   GeneTree; ENSGT00940000156561; -.
DR   InParanoid; A0A3B3H703; -.
DR   Proteomes; UP000001038; Chromosome 7.
DR   Bgee; ENSORLG00000007709; Expressed in brain and 11 other cell types or tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IBA:GO_Central.
DR   GO; GO:0031210; F:phosphatidylcholine binding; IBA:GO_Central.
DR   GO; GO:0008429; F:phosphatidylethanolamine binding; IBA:GO_Central.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR   GO; GO:0061817; P:endoplasmic reticulum-plasma membrane tethering; IEA:InterPro.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd08391; C2A_C2C_Synaptotagmin_like; 2.
DR   CDD; cd04050; C2B_Synaptotagmin-like; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 5.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR037733; Ext_Synaptotagmin_C2A.
DR   InterPro; IPR037749; Ext_Synaptotagmin_C2B.
DR   InterPro; IPR031468; SMP_LBD.
DR   InterPro; IPR039010; Synaptotagmin_SMP.
DR   PANTHER; PTHR45761:SF3; EXTENDED SYNAPTOTAGMIN-1; 1.
DR   PANTHER; PTHR45761; EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C; 1.
DR   Pfam; PF00168; C2; 5.
DR   Pfam; PF17047; SMP_LBD; 1.
DR   SMART; SM00239; C2; 5.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 5.
DR   PROSITE; PS50004; C2; 4.
DR   PROSITE; PS51847; SMP; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00023055}.
FT   TRANSMEM        51..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          102..290
FT                   /note="SMP-LTD"
FT                   /evidence="ECO:0000259|PROSITE:PS51847"
FT   DOMAIN          289..413
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          414..532
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          573..708
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          868..989
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   REGION          555..584
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        570..584
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   989 AA;  111481 MW;  9C541827CD3F4CB1 CRC64;
     LPALTEALLC PTPREQPFTP VVTAPPAERA VGALWSFAKC LGALLPVYLA GYYGFSISLV
     LLGLMLYIGW KHGRMEKVMR LKSAMYLLEN EREFTTEKVF RAKRDLPPWV RDTGVIFSLM
     QILQQAWPFI GQYLEKLLVE TIAPAIRTSS IHLQTLSFTK VNIGDKALKV VGVKAHTEHD
     KKQVMLDLYL SYAGDVEINV EIKKYFCKAG VKGVQLYGKL RVILEPLIGD VPLVGAITMF
     FIRRPKLDIN WTGLTNLLDI PGLNSMSDTM IMDAIASHLV LPNRLTIPLV ANLHVAQLRS
     PLPRGVVRIH LLEAEDLTAK DTVIKGLIDG KSDPYAVIRV GTQIFTSHHV DSNLNPQWRE
     MYEVIVHEVP GQELEVEVFD KDPDQDDFLG RYIHLRLEWL SLLSSADRLS EVIQKNQNLT
     TKTSDPPSAA ILAIYLDQGF ELPMRKGSKF PSPMAQISIQ DTTKESKTCY GSNSPVWEEA
     FTFFIQDPHK QDIDIQVKDD DHSVPLGSLT IPLNRLLETS DLTLDQWFHL ENSGTASRIY
     AKIVLRVSSG SEVGQGGITS DLSPAGPGGL NKPQPTQPQH TTPDPEFATE GVLRIHLVEA
     QNLIAKDNFM GGMVKGKSDP YVKIKVAGIT FRSHTIKENL NPVWNELYEV ILTQLPGQEI
     QFELFDKDID QDDFLGRCTS IKIKLGHKIW YTLNDVKSGR VHLVLEWLPR VSDLIRLEQV
     KLHFSFCSPF IAAICERSTS PRWDEAFHFL VRDPTDETLT VKVREIGWGQ ALGSLTLPLK
     EVLSESGLVL DRWLSLDGAL PESQILLRVT LKVNLKRNKC NISVTHEVKL LLSAVLILIN
     FFANIEKVQS NHERDIRQLR YVSDNANTAG QVKLTIGYST EENRLFITVH SCRGLAPRSK
     DGADPYVSFI LLPDKKATTK RRTTTKRKDL NPEFNERFEF DFSLEESTQR KLYLSVKNSV
     SFMSREKELI GKLQLDLDQI DLKAGVAQW
//
DBGET integrated database retrieval system