ID A0A3B3H7E1_ORYLA Unreviewed; 1538 AA.
AC A0A3B3H7E1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Calmodulin regulated spectrin associated protein 1 {ECO:0000313|Ensembl:ENSORLP00000027435.1};
GN Name=camsap1 {ECO:0000313|Ensembl:ENSORLP00000027435.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000027435.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000027435.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000027435.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000027435.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000027435.1};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- DOMAIN: The CKK domain binds microtubules. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
CC -!- SIMILARITY: Belongs to the CAMSAP1 family. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
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DR STRING; 8090.ENSORLP00000027435; -.
DR Ensembl; ENSORLT00000031437.1; ENSORLP00000027435.1; ENSORLG00000000683.2.
DR GeneTree; ENSGT00950000182975; -.
DR InParanoid; A0A3B3H7E1; -.
DR Proteomes; UP000001038; Chromosome 9.
DR Bgee; ENSORLG00000000683; Expressed in brain and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-UniRule.
DR GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR GO; GO:0051011; F:microtubule minus-end binding; IBA:GO_Central.
DR GO; GO:0030507; F:spectrin binding; IEA:InterPro.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR GO; GO:0007026; P:negative regulation of microtubule depolymerization; IBA:GO_Central.
DR GO; GO:0031175; P:neuron projection development; IEA:InterPro.
DR CDD; cd22265; UDM1_RNF168; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.10.20.360; CKK domain; 1.
DR InterPro; IPR032940; CAMSAP.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR031372; CAMSAP_CC1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR038209; CKK_dom_sf.
DR InterPro; IPR014797; CKK_domain.
DR InterPro; IPR011033; PRC_barrel-like_sf.
DR PANTHER; PTHR21595:SF3; CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR21595; UNCHARACTERIZED; 1.
DR Pfam; PF17095; CAMSAP_CC1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR Pfam; PF08683; CAMSAP_CKK; 1.
DR SMART; SM01051; CAMSAP_CKK; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50346; PRC-barrel domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51508; CKK; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|PROSITE-
KW ProRule:PRU00841}; Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 229..344
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1401..1535
FT /note="CKK"
FT /evidence="ECO:0000259|PROSITE:PS51508"
FT REGION 387..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 990..1210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1232..1333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1350..1389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 842..869
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 387..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..616
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 702..743
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..767
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1098
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1135..1150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1161..1180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1181..1195
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1232..1299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1538 AA; 169903 MW; 90B72037F2FC6136 CRC64;
MDVDLCAGGD GTRRKGELPG AAEGTMDVVP LEMYDSARAK IAANLRWLFA KAFGIDHIPE
DLRDPFYTDQ YEQEHIKPPV IRLLLSCELY CRVCALILKT EQAASLQSHL SVIQALARKG
IYVVESDDTP VTEEDLASMP IKMSAHMPMI DALMMAYTVE MISIEKVVAS VKRFSTFSAS
KELPFDLEDA MVFWINKVNM KMRETTEREH KVKHHPLESP SHQKSPSKWY WKLVPVRYRR
EHSSGRQLPF FPLLEDLMRD VCDGAALLAV VHYYCPDIMK LEDICLKEVP SIADCLYNIQ
LLREFATEYL NKSCYLTVED MLYSPLVLKH NVMVFIAELF WWFETVKPEF VQPRDLQEFK
DARAIAHPKS ARPSVPISNA TKRSFLASPG VADNQSSPEV CNSKGGPTFS PSHPLLPLRQ
RQQRQQGEDV SGLRNRSNSL TQMDAHHSRG SGVAWPDKRQ SRPLSTLSPF ALHSATDSDA
DRASGDSVSL ARSISKDSLA SSVANVTPKH QTSFHQPPHA ALRRVNGHGL LSNVSLEGEE
EAMLAVTRTD ASVLPRLAET APAGPKPPSD SKPAEDGFYL EPLMPAVLKT AKEKSVCLNK
EEESGEVLRS AERGSFRRGD GSAAAVRRKA PSGLNQTFEK EELVEPPPPA GFRPAVASSV
DSSSSSSREP AEGFYLHSDS EEQKYGAEME DLNEEEEDLD EALTTKGSHC PRKEYIEEAE
EEESAKLQED LNLKEHEDKD LNGGSGRSSP CLSTHSQASS LASGSVRMTS FAERKAHQQR
FGSNHDLRSS ASSSQRTTPD GSESSGPLAS SWRLRRDQSP SSPLGGCARA GDGGANVLAS
EIIQLRMQLE EKRRAIEHQK KKMEVLSARQ RQKLGKAAFL HIVKKGGGKS DTLPNPLKAD
ICKDEFNGEK EALSKDDTCV DVLRGEKGAE QAGSLGALGA DKRGNGGSFY LEEELDLNEC
SRSIELLNEA IGSIQQQMMQ LSLQQEVLMR QNTQSPSGAA PPLPHPTDKN GKVGGGFHFV
EHHSGAGGSQ TRKPPKLTSS KSSRSKPSEL KISKEQSQQS RPTSRTPTQS RSETLPNPRQ
LSGGRSPRTD QPDSPRNPTA AATIDRPGSG HARTATFRLH DEANMRLPTR VDLTSVSVEG
PQSSPRESEL HSADGSGKEN VPSEEGQRSK THLIEVDLSE LKAPEEDEGA EDGTAEEADG
EQKSGLGFFF KDEQKAEDEL AKKRAAFLLK QQKKAEEARL RKQQLEAESE LKRDEARRKA
EEDRLRKEEE KTRRELIKQE YLRRKQQEIF EEQGLAKPKT PRPKQKHKHK AVLREESSIE
SFSKCPSTPD NLITAQSGSS LSLASAATNE ADSVNSGGGG SQRCDSVESF PGSRNNSRAA
ERDWDNGSTA SSITSMAEYT GPKLFKEPSA KSNKPIIHNA ISHCCLAGKV NEPQKNQILE
ELEKCESNHL MILFRDGGCQ FRALYSYFPD TEEIQKLTGT GPKSISKKMI DKLYKYNSDR
KQFTVIPAKT VSVSVDALTI HNHLWQAKRG TVPKKSGK
//