ID A0A3B3H7R9_ORYLA Unreviewed; 752 AA.
AC A0A3B3H7R9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=RAP1 GTPase activating protein 2a {ECO:0000313|Ensembl:ENSORLP00000027273.1};
GN Name=rap1gap2a {ECO:0000313|Ensembl:ENSORLP00000027273.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000027273.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000027273.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000027273.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000027273.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000027273.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3H7R9; -.
DR STRING; 8090.ENSORLP00000027273; -.
DR Ensembl; ENSORLT00000044966.1; ENSORLP00000027273.1; ENSORLG00000014038.2.
DR GeneTree; ENSGT00940000165230; -.
DR InParanoid; A0A3B3H7R9; -.
DR OrthoDB; 25782at2759; -.
DR Proteomes; UP000001038; Chromosome 13.
DR Bgee; ENSORLG00000014038; Expressed in intestine and 11 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF17; RAP1 GTPASE-ACTIVATING PROTEIN 2; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 276..492
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..745
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 752 AA; 82609 MW; 810F71DBBB75A580 CRC64;
MVAQPPSVTH SPSPGCGSTA DAAPSPDCQM FTPAFKAPAG ESRIDKSTLA ALRARKQELL
NITNVPIGEC PPSPPRTAPP TMKSAEFFDM LEKMQVPKAE ETKKWKDDYI PYPRIEDVLE
KGGPYPQVIL PQFGGYWIED SEAPAGTPSS SESSFCEEDE DGDEAMSPGG AHSFRLECNS
TARAYGKHFL GKEHMNYYCT GSSIGNLIMS LKHEETEAQE FLRIILRSRT KTIHDRISLA
GINQLPSVPQ IAKLLCDDAT GIKFNPVLYP RGSRLIVAYD EHEVNNTFKF GVIYQKFGQT
SEEELFGNNE ETPAFKEFLS VLGDNIELQD FKGFRGGLDV SHGQTGSESI YTVFRQREIM
FHVSTKLPFT EGDVQQLQRK RHIGNDIVAA VFQEESTPFV PDMIASNFLH AYVLVQAENP
CTEHTTYKVS VTAREDVPSF GPPLPNPPVF KKGPEFRDFL LTKLINAENA CYKSDKFAKL
EGRTRAALLD NLHDELHRQS QAMMGLGQVG EEDKLENGGH GGLLESFKRA MRVRSHSMET
MVGSQRHRSP GVGGGVPASL SGGGLPQSTS ECTKSTFTPP TMSAKSPLKS PVKRRSGLFP
RLHSSTESPA DRHSRIDQKP AEFYPASQEV RSETSSNPSS PEICPNREKP FMKVRESTSS
CRPNISRSSS STSSFSSTTG ETEALEELES AAQHSFTASS SAFSPTLSVD SQGCSTPVIM
CRSPTDGKSK TSPRSHLKFR FDKMSHSSAT TE
//
