ID A0A3B3H810_ORYLA Unreviewed; 1621 AA.
AC A0A3B3H810;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Apoptosis associated tyrosine kinase {ECO:0000313|Ensembl:ENSORLP00000028064.1};
GN Name=AATK {ECO:0000313|Ensembl:ENSORLP00000028064.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000028064.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000028064.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000028064.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000028064.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000028064.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSORLT00000044485.1; ENSORLP00000028064.1; ENSORLG00000030499.1.
DR GeneTree; ENSGT00940000154244; -.
DR Proteomes; UP000001038; Chromosome 19.
DR Bgee; ENSORLG00000030499; Expressed in bone element and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR PANTHER; PTHR24417; SERINE/THREONINE-PROTEIN KINASE LMTK1; 1.
DR PANTHER; PTHR24417:SF0; SERINE_THREONINE-PROTEIN KINASE LMTK1; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1621
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017284921"
FT TRANSMEM 34..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 131..401
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 940..983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1031..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1321..1444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1508..1584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 959..983
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1098
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1111..1136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1164..1178
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1204..1243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1254..1271
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1321..1337
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1338..1357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1402..1421
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1508..1537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1551..1566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 162
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1621 AA; 179291 MW; 8180739B819E0DE1 CRC64;
MLVPLVTMAS VLFSPGFALS SHFSPDGAPL SELSWSSSLA VVAISFSGLF TFVFLMLACL
CCKRRRMGFK EFKNADGDEY HADLSTLASP ASQGGPDVYI LPLTEVSLPT AKQPARSVQL
LKSADVGRHS LLYLKEIGHG WFGKVLLGEV TSGPTTTQVV VKELKASAGV HDQMHFLDEA
QPYRALQHPA LLQCLAQCTE VTPYLLVMEF CPLGDVKGYL RSCRANESMA PEPLILQRMA
CDIAAGLLHL HKHNFTHSDL ALRNCLLTAD VSVKIGDYGL AHSKYKDDYF VTSDQVFVPL
RWIAPELLDE VHGNLLVADQ NQQSNIWSLG VTLWEMFELG NQPYRHYSDR QVLTYVVRDQ
QLRLPKPLLK VPLAERWYEV MQFCWLQPDQ RPNAEEVHLL LSYLCAKGAN EAEEDFERRW
NSMRPNTGCS RSTSAMSREH CVSNSSSFPL LEQFVSGDGY HSESGDDVLT VTETSQGLNF
EYKWEQARAE QPFIASHSSS SLSLASRHCQ EAFYPPGGIV GGCPLESLNR GISPSYYQAK
HIHAPSVLPV LSAHSPSVSS EYYIRIEEPV DCNIDPEYTM GSYSPDYPGS AGSFMTGSAE
SGECMTCPLQ TENMGPYWSS EVHKTDLYDS NDSSPAISLT MEPLLGQVSD SSPLQPWESS
HYVSYKNQDG GYYYEPSPPL GVDHYLLGNE HHQESWGSRS LRQALGEMES SPVSSRQRTY
RDSYLDTSQT SILGKTVTGG YYDMMGSLRK TMPSHTGHNS HSVSINMETQ GALFIGHRES
DSEEDEDDIF IERHSCNTWP SKHRHSSASH HRRASHSCRQ DAYADFHYTM PSTDIEDSWP
EDHNLVFHSL PKPIDYLEPH QVKDNSACLS LTNPMVPSDN CNAYIYLCRE VDTQPESRDC
CHPQFVDPLT GLLVRNNSFC PSYSHSSYLT DKATDIPNNE ELINLSPAPG GPIVSKPAPK
KPEDSEEQYA DLSADKTPLK ENRDGPIKEK IMQKPPEPRL EEVALTMTKA TPPPPDNMHV
MVALMDPQSE ISPSADSGME RRGSTVSLAD ILDCSDEDDT TDEITDVTSG IFVDECSELN
SSPAIKSLQK QIGTPDSMDS MDLLSVAGSC EGLSPASSRP SSSPKAMDSG YDTENNESPE
FVPKESHEQW PSSQGKPALE TSLEEDEEGH DPEDALFNDD DDLKASGALQ PLSDKTPYRD
SAYFSDYEND RQSREEEEVS EQNDSEKEGG QIKEEEPKVD VDLKLQAESS SPEIREQLFE
ENPRHEEEGS PQGLSDSSAE GLLDEWPSHE ETSSMGDWAA EVVGAMEEAI GALNGDCSTA
FKADDRKKEE HKTSIQASET NEETPVKSSQ NRPSGTSGEH PHVLPKDEVA LQHTAHARRF
LCSSTPPPST PPATEGRTCP AEGEEADEED GDTEDSDESD EELRTYSVQE QSGGEDSEDE
CHRVPIVVSD CSEARLRSLL RKPTPLTADN LEEELARKTK TVTFFDNVTV YLFDQESPTK
ELTEHILTSG TEDQSSGGQT QEKLNASDDS SDGNISEESG GFEWDDDFTL HPLPTSSTVN
DSPPPQSFTK TPDPKPPVQL SRFTVSPSSV SRFSRFSITH ISDSDVESAG GWFQLQLGAF
L
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