ID A0A3B3HBI5_ORYLA Unreviewed; 1562 AA.
AC A0A3B3HBI5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Zinc finger homeobox 2 {ECO:0008006|Google:ProtNLM};
GN Name=zfhx2 {ECO:0000313|Ensembl:ENSORLP00000029206.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000029206.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000029206.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000029206.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000029206.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000029206.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR RefSeq; XP_011487103.1; XM_011488801.1.
DR STRING; 8090.ENSORLP00000029206; -.
DR Ensembl; ENSORLT00000035470.1; ENSORLP00000029206.1; ENSORLG00000023291.1.
DR GeneID; 101157653; -.
DR CTD; 85446; -.
DR GeneTree; ENSGT00940000160537; -.
DR InParanoid; A0A3B3HBI5; -.
DR OrthoDB; 4249381at2759; -.
DR Proteomes; UP000001038; Chromosome 20.
DR Bgee; ENSORLG00000023291; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 2.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45891; ZINC FINGER HOMEOBOX PROTEIN; 1.
DR PANTHER; PTHR45891:SF3; ZINC FINGER PROTEIN 2; 1.
DR Pfam; PF00046; Homeodomain; 2.
DR Pfam; PF12874; zf-met; 2.
DR SMART; SM00389; HOX; 3.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SMART; SM00451; ZnF_U1; 2.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 170..199
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 227..256
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1024..1084
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 1351..1411
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 1026..1085
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 1353..1412
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 62..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1005..1027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1163..1189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1212..1251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1302..1354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1513..1562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..486
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 782..815
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1005..1019
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1167..1189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1319..1338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1513..1546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1562 AA; 168325 MW; 5F759C8C2678AC05 CRC64;
MQEESGELVR SQRNGVAKWV CPLCQQGQSN RSSLSLHLNE QHSVLPSCVN RLLDIIVLKQ
SSSQEEEENQ APQSTDTESL QVRHTEDGSS EPQQSRESSD PTQMLGDKDM DEKRVMEQEG
GKVQQELEEE ETPIAGAKQR NATESTEMSN TSEKLLCKNG VPAENNTRSF KCNACQESFS
SRTALSVHYT CTSHIQRMTT GSAKQGAESN PQSPSVSARP FTLNKPYQCA VCRVSYNHAI
TLESHMKSVL HQTRSRNAGM VAQTVNSATA AANLRGNAAS ASTIVVTSGS ETGHLVTSSN
SAAPGSLMPS SAEEGEQIPT SQVAQSLLAS PVASAQAVSA FLTLLTSSPN TLSHSLLPSL
FTASAAPGAA APQLVPQPQM IMPLILNGLQ AQTQQHQENQ QGQLLTQCVP FVGLGAAQQA
LLTQRLNSLQ NQWPSAGLLN IQPSQEDPKQ TVLSEGEISE ELDQCASKEV KVESNEGSRK
ERRSSSDGNS ATNQLESGGD KAAVLNLSPA ATEKSLCNNI SPSASMPSNA SLSPVNINLT
LSPDPTPQKP LMDTSPSDSP KSSPSSNALT TNQTRLHSKP VRSSYPDLPV LSEFQSEVLW
AFFESRSEAD AASPPHEDCE ALGREVGLSE EEVRKWLTQA CHAKQRQRAM ELERQCQGSD
DYDDDEESML VIAEAESESD VQTSSGRAID LSNNRRKHKP RVVGRKGQED SCLTSDSENE
AYTSIIVSDE ESRVDLVKES CESPAKDETQ QDAQNGSAGG KVLRSTTVFL SDAEDEYEDD
EGGGSQGAKR KKRKGEFERD EVEVKRERPD PDVDLELEAQ GDPPSSHASV TDVAGIVPAA
LHSFPLSLGP FSAQFLNPYV LSLPPSMLTD GSKMPLFSNP QNLTRFSNSL LSQSLSSHSP
LSPYLSNGDD CESALDLSMG KNNSKPTSSS SSLADSIAAQ KGQLLDGLGL RPTSKGLVVV
QVKPESIATM SPSSSPINLV NCSNVATPHM NARAAAKMNA MLMEREREKD REQQQRKSKG
KRYRDMRRSR TIIQAEQLDI LYGCYFKDPN PGKHEFEQIS EWVHLPKKVV QIWFQNMRAR
ERKGEVRFIS DGTLAAVGKP LIKFTWPLSK PIFSNKSASN NTGGITATPI VRTLIKTERE
SGKELDKAVM VKKIAPVPIK PKEMSSTAVG SPVSSSASSM PKTHPETTSN VTMVKVAPKV
NTPVLLAAPR DLIPIAPRPP HPQKAEESEE EKTDEEKDDG TEMTSGPGIA NRMVPKLATT
PINNRSSLTA VVPQKQNGLN YWTPKVPIKI NTLSREQLAL PTHSARTIPP PPTPNIAPVS
PNTQSSAKAA SPSTPAVAKS SPGDGGFLSH SSSRRPRTHL SCLQLSILQS CYETCAHPNA
MECEAIGSEL NLPLKVVQIW FQNTRAKEKR WRLQQEKLSP LTGGKVDMSS GGYLQYSALK
ANRPILPKPV QLTVTEPLAS PVPGQPVPKE ALTGHCDTCK VSFESRAAAR AHVFSPRHLA
TLRTTNFGQP TALVKSGSST NGSGSILPSS QVSLPTPVTS SGSGSEGEIV IELPLTTATS
SS
//
