ID A0A3B3HBP8_ORYLA Unreviewed; 2244 AA.
AC A0A3B3HBP8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
GN Name=tspoap1 {ECO:0000313|Ensembl:ENSORLP00000028668.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000028668.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000028668.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000028668.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000028668.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000028668.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RIMBP family.
CC {ECO:0000256|ARBA:ARBA00010749}.
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DR Ensembl; ENSORLT00000037010.1; ENSORLP00000028668.1; ENSORLG00000011077.2.
DR GeneTree; ENSGT00950000183203; -.
DR Proteomes; UP000001038; Chromosome 14.
DR Bgee; ENSORLG00000011077; Expressed in testis and 14 other cell types or tissues.
DR CDD; cd00063; FN3; 2.
DR CDD; cd12014; SH3_RIM-BP_1; 1.
DR CDD; cd12012; SH3_RIM-BP_2; 1.
DR CDD; cd12013; SH3_RIM-BP_3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR035753; RIM-BP_SH3_2.
DR InterPro; IPR035755; RIM-BP_SH3_3.
DR InterPro; IPR040325; RIMBP1/2/3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14234:SF20; PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR-ASSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR14234; RIM BINDING PROTEIN-RELATED; 1.
DR Pfam; PF07653; SH3_2; 3.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 929..996
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1945..2013
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 2069..2136
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 175..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 843..909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1478..1525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1538..1567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1685..1734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1749..1796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1820..1843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1892..1942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2140..2244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 18..67
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 374..444
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 609..797
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 180..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..328
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..564
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 864..894
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1054
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1481..1495
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1547..1561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1702..1729
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1750..1764
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1765..1779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2158..2203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2244 AA; 247075 MW; FA05A37D4F26CDF5 CRC64;
MRDDRDNPLA LSFKSSSCND YSQELRRLRA DLEVEKNQAA WACGRLAVEL RRLREEAERE
HQRAVKELAA RRGSRKSQNG SRNLLVEDLR NKDDGQFCKG VPTGEETFHF CSSQTQLLLD
KINGKDAPFK SQDFELEKAI LLCHLLETHG QLLRGTQKTK SQRCAAKCSS KKQAKEETSK
PYKTSTFSNY PSAPQLKPQG DSHSSQRSKL EGWRQSLECN LPADASCFST KTCPSTSLTT
GHPHPPPTHA GQENRASNWT ESSGTDESSI SKCMGRNMER VMYDLCSRPE QPEPAPEHAD
MESSNGMEAL GKQQEKLNES EKHSNNNDVP KTAKLATKSL LGKRHHSLYA NLSGFEAEGV
QKNGTDYGFL VRQNSELLRA LDDLEKTCST LKEENGLLRK SSAPGTEEKV RRLRKKNTEL
AVLAKRLEER ARKLQEANLR VVNSPSLMRP GSAEHYKRAF ARQRARDLAH HADALLSKDK
EIAALQQECR ELEAQLGHSK GFPLHSSRGE FENLLRESQK EVLRLQRQLS VTSSRHQDDT
ELSVKTCGEN TKDKGQEKVE GETPSVGLDE APSRSAKTPT EEGESWLRVT PPSGLSPSPS
SQEDPQQRIQ FLERELNNKR KECEDFEHEV KKRQRRCLDL ESQLENERGK NEHLKEEADL
LRRKALLLDQ ARAENEELRE ELSEVTAQRN SVLEENQRLR AKLENLEQVL KHMREVAERR
QQLELEHEQA LAILKFKQDE IKRLQRAQLF AKREHEGVVQ MLEELTQLVL RRELSKVREL
EEKCRNQSEQ FGLLSQELEK FRLQASKVDL ASSTLLNTPS LSVLTNGVGL TTERDVAAAL
RMGATPHPAG LTRAERSPVT KHRELPTISV SKSASSSNKS ETAHLTPKSD THLSPHKSSP
THEVDTASEV EELDIDVALA PYTASRGAAK LQVFIARYSY NPYDGPNDNP EVELPLTAGE
YIYVYGDMDD DGFYEGELMD GRRGLVPSNF VERVSDDDFM SAHQPDTGDA SHNSLLVSSL
HSASHQHHLH SGVSASAPAS APPDSRTAST VPPPLTNGLD LDLEEVGVDL VPYPRKLTLI
KQLAKSIIIG WDPPLVPAGW GNVFSYNVFV DQELRLNVPF GAQTKAVLER LDINLKAYRV
SVQSLTEKGV SDQLRCSMLV GRDVCVAPTQ LCVDRVTATS ANLTWLPSNS NYVHIVSLND
EECELVKAGC YSLCLNNLLP SLQYTVKVEA RPHRTPWELP VERREHRSAT ITFSTLMAGP
PDAPLDVQLE QGPSPGIALI SWLPVTIDAA GTSNGVRVTG YSIYVDRKKV LEVSSPTAGS
ALLGPSQMQC LQAAQELTLR TMSAHGESCD SLPVKVPSKL AAIMAGPAFS SPVVPAALCA
SPASSIVAPH PSYGNCTANV STSPLPLDTH IPGLRVEPTT KTHGALHSDH HPTNASYVMA
WANPSAAAAL SVCEAPLPAP SAITPPVNVT TSIISTPPQA CPAAAPSPTQ APTAAPAPVL
EPRRDADSPG TIRPFPSITE FMEDPSDPKF ATPERIPTPP KAPITDLLNP QCSNILRPPS
TSPLESEVEE ELENTRLVSI EEFLRQDQDP AYCRTQQSYS RGFEEPPSDY NADNSRSDLS
DILEEEEEDL YSDHLLEGQP RGYSVGANRH CKFGTPDSEE ETRERILKLP PQVCQNKQLF
SIAEVTEEED SSQEEALAHR RKARSGHSHL HHSGHHHAPQ HHANPHNPSH HHHFNRDLRS
LALRQEPLQV KPKTQHRVHY TDTVSYPEDE NSSMYEGHTS RRVSAHPPPK HTPIGKERSL
LRGLGDRLRR EALLRSQMAV AATVPPDPGP TPPRSYPVSK TVRSVKSPVG RRMEIDVEYG
TDTEEPADYN PGEVVLEQMS SEWWVEGAPV EHCRPSHRRG PKAEPTDPSL IPPAVAAPPW
TSQAELSGKA TKTPKGESPK IKGDGDVRIF VALFPYDPAS MSPNPDAAEE ELPFSEGQII
KVYGDKDADG FYRGESAGHV GFVPCNMVSE IQVEDEETRQ QLLQQGFLST ATSMEKIVES
AALQEESVDS CGPEPCQAAP PTVTGKPASG ARRMIAIFDY DPRESSPNTD IEAELTFSAG
DVIHVFGDMD EDGFFYGDLN GHRGLVPSNF LQAFPDEAPA EAACAPPAPD PKKESQDTST
EPQGSGPPSL EETPNPQSEA PHPSRSEATQ LNPTTSTSSD PDPPAGPANV AVCCSSPTPL
PSDSPAPADC SAQAKKKKGF FSKD
//
