ID A0A3B3HC50_ORYLA Unreviewed; 471 AA.
AC A0A3B3HC50;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DNA polymerase delta subunit 2 {ECO:0000256|ARBA:ARBA00017588};
GN Name=pold2 {ECO:0000313|Ensembl:ENSORLP00000029115.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000029115.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000029115.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000029115.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000029115.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000029115.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA polymerase delta/II small subunit
CC family. {ECO:0000256|ARBA:ARBA00006035}.
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DR RefSeq; XP_004072565.1; XM_004072517.2.
DR AlphaFoldDB; A0A3B3HC50; -.
DR Ensembl; ENSORLT00000044228.1; ENSORLP00000029115.1; ENSORLG00000012796.2.
DR GeneID; 101156744; -.
DR KEGG; ola:101156744; -.
DR CTD; 5425; -.
DR GeneTree; ENSGT00390000006780; -.
DR OMA; HCILIGT; -.
DR OrthoDB; 1604at2759; -.
DR Proteomes; UP000001038; Chromosome 9.
DR Bgee; ENSORLG00000012796; Expressed in animal zygote and 14 other cell types or tissues.
DR GO; GO:0043625; C:delta DNA polymerase complex; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd07387; MPP_PolD2_C; 1.
DR Gene3D; 2.40.50.430; -; 1.
DR Gene3D; 3.60.21.50; -; 1.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR040663; DNA_pol_D_N.
DR InterPro; IPR024826; DNA_pol_delta/II_ssu.
DR InterPro; IPR041863; PolD2_C.
DR PANTHER; PTHR10416; DNA POLYMERASE DELTA SUBUNIT 2; 1.
DR PANTHER; PTHR10416:SF0; DNA POLYMERASE DELTA SUBUNIT 2; 1.
DR Pfam; PF18018; DNA_pol_D_N; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 51..177
FT /note="DNA polymerase delta subunit OB-fold"
FT /evidence="ECO:0000259|Pfam:PF18018"
FT DOMAIN 198..412
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 471 AA; 52089 MW; 81226C6FD26C5681 CRC64;
MFSDVSAQKN GPSLLCSPAS EEQGPTFERI SLPYELYSDR YRVGQRSFSR QYAHIYAARL
MQMRPLLAER AQQKWGSNVL IKKLCDLEPG EQCCIVGTLF KRMELQPSIL KEISEEHNLL
PQPARAKYIS EADELILEDE LQRIKLEGKF DKDKCVTGSV VAIYGAEKND GKFTVEDFCM
ADLPLQTPRP ALSSDRFVLL ASGLGLGGHN ADSMLGLQLL VDMVTGQLGD TGEQSGAAAI
SRVLLAGNLL SQNTQDKDAS TKAKYLTKKT QAGSVEAIRV LDELLLQLVA SVPVDVMPGQ
YDPTNYTLPQ QPLHPCMFPL SSAYNTLQLV SNPFEASIDG VRFLGTSGQN VCDIQRYSSM
DSHLEILEET LQLRHLAPTA PDTLGCYPFY QKDPFILEEC PHVYFSGNAP TFESKLIKGP
DGQEVLLVTI PEFSSTQTAC LVNLRTLQCE PISFTAFSAD KDEENEMNIS H
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