ID A0A3B3HCQ8_ORYLA Unreviewed; 1522 AA.
AC A0A3B3HCQ8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=RecQ like helicase 4 {ECO:0000313|Ensembl:ENSORLP00000029591.1};
GN Name=RECQL4 {ECO:0000313|Ensembl:ENSORLP00000029591.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000029591.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000029591.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000029591.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000029591.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000029591.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR Ensembl; ENSORLT00000035061.1; ENSORLP00000029591.1; ENSORLG00000024764.1.
DR GeneTree; ENSGT00940000160387; -.
DR Proteomes; UP000001038; Chromosome 11.
DR Bgee; ENSORLG00000024764; Expressed in blastula and 10 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd18018; DEXHc_RecQ4-like; 1.
DR CDD; cd22289; RecQL4_SLD2_NTD; 1.
DR Gene3D; 1.10.10.1460; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR021110; DNA_rep_checkpnt_protein.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR13710:SF108; ATP-DEPENDENT DNA HELICASE Q4; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF11719; Drc1-Sld2; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 609..623
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 741..919
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 941..1128
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 52..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1157..1212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..407
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..443
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..476
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..515
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1522 AA; 168313 MW; 4F659FB4504058FB CRC64;
MDRYNELKSL LKRWEQTFVE QHRKKPCKED VDRAPADIRG LYLEYRSLRR AREEGSHAAH
REPPPSDSWG AHLNRRAMPG PPPKLSQQDR DALQASSQYY GLKLKSNLAA LSEEKPALLK
KTKLTGRVPL SFLTDQKSRT GSAPSAGAAQ TVMVEPPSSP PRRRTPPSLV SPTCSPAEPG
EPFRAFEAEA GDASPQGATG GSPRGSPRGS PRGSPGGSPR GSPGGSPRGS PRGSPRGSPR
GSPRGSPGCS PGCSPRGSPR GSPGGSPGCS PGCSPRGSPR GSPGGSPRGS PGGSPRGSPR
GSPRAPGSRG TSHRNTEWGT SGHSEGCPPF MKRGVAAGLG RPTPAKRLSA VDRKWLQRCQ
VFGELCLEER PAAGNQEMKP EERREENRKE EGSEDDRGGK TEADMKTVRV LEAPQLQTQE
TGGDGNQKRE EQTGGELRES VTPDLDRNLN SNKTQRGGRK RQREEDVLEE GGQEKKKQRR
RKKKDEGPHV PPREEETTKK KEERSERPHE AFRENLLGEV QEEFEAKMFR TPSAKPRVTR
GAEGNFVKIN LKKKSHVKGY ALRGQGLRRQ LSMQKFQMKG ERFGGGAGRF SGGRRGGFRG
GPSRHGDTCF RCGGSGHWAM DCRGAASAGP PLPVPEEPPA EGDEEAFELP TLEDVARATG
TLQPGPADAQ HQLEKEDNQQ EDELLLNVIR PDYECPPPPP PMEPLYHLTE EGKVQETPEA
VHSALRELGY QSFRAGQEEA IMRILSGLST LVVLSTGMGK SLCYQLPAYL YAQRSKCISL
VISPLISLMD DQLSGLPTKL RAACIHSNMS RKQREAAIEK VKSGQVCFLL LSPEVLVGAA
GSGMGCLPSA QELPPVAFAC IDEAHCVSEW SHNFRPCYLR LCKVLRERLG VQCFLGLTAT
ATLSTALDIA QHLGIRDQEG ISVRSAAVPP NLNLSVSMDQ DKDQALVSLL KGDRFGCLDS
IIVYCTRREQ TLRIAALLRT CLQGVLLKHN NQSSQINPAA QRKKELAKKK IRKPLKWLAE
AYHAGMSAAE RRRVQNNFMC GELRMVVATV AFGMGLDKPD VRGVIHYNMP KSFESYVQEI
GRAGRDGEPA HCHLFLDAEG ADLHELRRHI YADTVDYYSI KRLLQRVFPA CTCKRMQQHQ
RERWKDVEDS DLLEMMDEHE QENKQDPSSQ QNQADASGVQ DLSGSGQTSM EGGAGGEDLT
TRDTSGSVWP QQRACRTHER AIPIQEVVEA LDVPEEGVET LLCYLELHPQ RLVELLHPTL
SVCKVSCYDG PKQLRKIAKI CPPVAAVLAR KRMAGERVER CDQVEFDVVE VADIMGWQLP
LVKRGLRQLQ WSTDRSGGRS GVLVEFSAPS FYFRSYGDLS HGEMDRLCRF LHGRVQEQER
TRLHQLTACF KAFRSVAFQS VLSCGRHLDG SRSSQLKTLL SDYFDKKRDG GGAVQQEEPE
EPDKHELLEW EEPIRADIRR FLAHRSDEKF SGRAVARILH GIGSPRYPAV IYGKDRRYWR
KYIHFDFNRL IQMATQEIIG FK
//
