ID A0A3B3HDF4_ORYLA Unreviewed; 1888 AA.
AC A0A3B3HDF4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Rho GTPase activating protein 21 {ECO:0000313|Ensembl:ENSORLP00000029836.1};
GN Name=ARHGAP21 {ECO:0000313|Ensembl:ENSORLP00000029836.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000029836.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000029836.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000029836.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000029836.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000029836.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasmic
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004284}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004284}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004395}.
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DR Ensembl; ENSORLT00000030473.1; ENSORLP00000029836.1; ENSORLG00000013115.2.
DR GeneTree; ENSGT00940000155406; -.
DR Proteomes; UP000001038; Chromosome 20.
DR Bgee; ENSORLG00000013115; Expressed in brain and 13 other cell types or tissues.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01253; PH_ARHGAP21-like; 1.
DR CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR Gene3D; 1.20.5.220; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF16; RHO GTPASE-ACTIVATING PROTEIN 21; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 58..166
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 894..1008
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1119..1312
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1058..1103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1348..1376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1392..1535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1550..1762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1812..1878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..314
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..856
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1076..1092
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1348..1368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1443..1474
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1482..1520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1550..1572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1579..1599
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1601..1616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1694..1710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1711..1746
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1888 AA; 205380 MW; 3C5DE6E1392F5272 CRC64;
MMAARWSNTT RDNKENQHAV LTPACQAKPK DGREQSEPSA TASPGAEEEP FSWPGPKTLC
LRRTSQGFGF TLRHFIVYPP ESAVHNSLKD DENGSRGRQR NRLEPMDTIF VKQVKEGGPA
HGAGLCTGDR IVKVNGESII GKTYSQVIAL IQNSDASLEL CVMPKDEDIL QLAYSQDAYL
KGNEAYSGNA QNIPEPPPIC YPRIELKTAG SAQTSEPLPG PGRRGGAAEK SYRMEIPVSP
SPLQAAARTA PPDPVERGSQ LARAGPSHRA EENRYGVSAN RTAVPSGQGG TQLQHPAQTP
VFPPAKPAAA HPDTLPPPAR DATSAAISPS PNHCSPSPPA PPSSPHQHID WRNYTTYKDY
IDAKRLHSYG CRTIQERLDS LRAAADSAYS QQRTPPPSNS QRGAPGSQVR RRSASNERGG
DISCTGAAPL RSVSQDRLGG GTERAAADRN WPRSASQDAL PFSPAVRVLK PRARSCDYLS
QPPVERGGAD PGDRAAVEER LLQCRAGLGS GQKALPHLRR NLAVQEEETQ RGGSSSPPAA
AADPTEGTTD SAPTSRTEGL ILRPSRLPVK TSEAAPASSP AKTADPLKDQ RAGAMGNHQD
SCPPLHLQLR SRADSLKVEN RSESGLAARS SSCSGASSKP LRQPHIGVVT VSSRIPPPNR
AVTQKPYSGS AQALFRTNHG SAEGVEGPDS TVVVLRKDRN FGPARPRPPS YAFAVNDNKE
EVAYRPPPLV KAGSADGAMC WMSAESCRDL HLRGLGENRQ QSGSTNLDNS LDSIPFIDEP
SSPSIDLDST HIPASVVICG TPTITTIPPS PTSSSPLIRR QLSHDQDSFR LTIVESDSGS
KTERSKSYDE GLDNYQDGRG RSLIPGLKGL RKAIDRSSED SGSRGDSSSD VFCDATKEGF
LHFKQLHTDK GKRVGGGMRP WKQVYAVLRG HCLCLYKDRR EGQAHASCQT VEEPLQISIK
ACLIDISYSD TKRKNVLRLT TSDCEYLFQA EDREDMLAWI RVIQENSHLD EESAVFSSHD
LISRKIKEYN TLMSPTGSKS EPSPRTSRQS LSIRHTLLGG KGEAKAPSPQ SPKAEVEKRS
VLKDDTSPPK DKGTWRKGIP GLMRKPFEKK SSAGFTFGVR LDDCPPAQTN KFVPLIVEVC
CKLVEERGLE YTGIYRVPGN NSAISNMQEE LNNKGVSDID VQEDKWKDLN VISSLLKSFF
RKLPEPLFTN RRYADFIEAN RIEDPVERLK VLKRLLHELP DHHYETLKFL SAHLKTVAEN
SEKNKMEPRN LAIVFGPTLV RTTEDNMTHM VTHMPDQYKI VETLIQNYDW FFTEDGNGDP
VTLSRQESAV ESQPVPNIDH LLTNIGRTGA SQGEVSDSPA SDSAKSKGSW GSGREPCSRE
LLVSSIFAAA SRKRKKSKEK VQPSSSDDDL DPVFSAMELP AQKPDPRGLQ AETQTHPGPD
GRQEAAALER KENGGVPELA SKAKREHRIS LYLKETPPKQ HSPNAIRRNA RQGKSSLSDP
PSQLEENPSD LGTMSSGASV PRSRPKKWAA GGSPDLLVNI GVSARAEVSS ITSDYSTTSS
NTFLTGAESS ALSPELQLGE DADDERSELI SEGRPTETDS ESDFPVFSAA QSTPRPEQSQ
DRKEQGGAAA GGPAPRPEAR RLFPSQKMIE SDTLSRRWSF RQKTDSDSSA EGTVGGEGRP
ESSTRLSRVL EVMKKGRSSS SISSSSRSES ERPEPPWHLK ITERLKFRLR SSADDMLAPR
SRAAEARGKK RSIRRRHTMG GQRDFAELAV IHDWREQGGG DGAADLSALD RLKPRCSSQD
FSIRDWIARE RCKGSEPSAA VAPKAVPEDD PAEAQGHAPQ GRSPGAPAGE QLNGSGPQSK
NKPSLGTDPH PHKLSGAQVV RSRFYQYL
//
