ID A0A3B3HHR2_ORYLA Unreviewed; 916 AA.
AC A0A3B3HHR2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Potassium voltage-gated channel subfamily Q member 5 {ECO:0000313|Ensembl:ENSORLP00000031304.1};
GN Name=KCNQ5 {ECO:0000313|Ensembl:ENSORLP00000031304.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000031304.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000031304.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000031304.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000031304.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000031304.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3B3HHR2; -.
DR Ensembl; ENSORLT00000046148.1; ENSORLP00000031304.1; ENSORLG00000002279.2.
DR GeneTree; ENSGT00940000155933; -.
DR Proteomes; UP000001038; Chromosome 15.
DR Bgee; ENSORLG00000002279; Expressed in animal zygote and 9 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR PANTHER; PTHR47735:SF8; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 5; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 108..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 108..337
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 429..612
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 847..916
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..649
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..705
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..890
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 916 AA; 100747 MW; 656E8D6AEBBC87BE CRC64;
MPRSSTGEEG GGTGLWMKTA AGKRTQEYPL KDVESGRAAM NSAARAGDGL LRAGAAGAAG
PDRKQGARLS LLGKPLTYSA QSGRRNARYR RLQNCLYNVL ERPREWAFVY HAFVFILVFG
CLVLSVFSTI PAHQEFSSHC LLILEFVMIV VFGLEYIFRI WSAGCCCRYR GWQGRLRFAR
KPFCVIDIIV LITSVAVVSA GSQGNVFATS ALRSLRFLQI LRMVRMDRRG GTWKLLGSVV
YAHSKELVTA WYIGFLVLIF SSFLVYLVEK EFNKDFDTYA DALWWGTITL TTIGYGDKTP
QTWTGRLLSA GFALLGISFF ALPAGILGSG FALKVQEQHR QKHFEKRRNP AASLIQCVWR
SYAADENSVS IATWKPHLKA LHTCSPANQK LSFKERVRMA SPRGQSMKSR QTTIGDRQRC
SPGSEVVGSN ELMSGSPAKV QKSWSFNDRT RFRPSLRLKS QARNATPEGD GGAATEDSFE
RGCHCDVTVE DLSAPLKAVI RAVRIMKFHV AKKKFKETLR PYDVKDVIEQ YSAGHLDMLC
RIKSLQTRVD QILGKGQIPV EKKPRDKLHP DGDSLEGMSM LGRVCKVERQ VSSIESKLDS
LLDIYRQVLQ KGSSGLSSLP LFELENHQRH GSDFPLSPHR GDAIRSRDEG GGMQRSLSAS
PRGLRLILAP ADDECPPDSE PPSYPPSTAS LSPSPLLPPD SPYPTLVTPS KKSQFPDLPP
PPSSSGSFTL QLPPMVPPNL RGPVQPMSDE VMDESSLAPP VVVRCSVDDD DDEDDDGEVE
GGAGSTQGRV QLRKKPPLKS QGLWRRHLSL EVNPLKLLSS TQEAGPADWA GSLGKSLSVH
NLSQPLGNPR LSSALDNSIS SSNGSERGND QLSSWGGTDF FNSESNLEEL QSGEEAAPHP
NGQQEFLRQS SDIQLV
//
