ID A0A3B3HI74_ORYLA Unreviewed; 1118 AA.
AC A0A3B3HI74;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 12A {ECO:0000256|ARBA:ARBA00044128};
DE AltName: Full=Myosin phosphatase-targeting subunit 1 {ECO:0000256|ARBA:ARBA00044333};
GN Name=ppp1r12a {ECO:0000313|Ensembl:ENSORLP00000031631.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000031631.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000031631.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000031631.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000031631.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000031631.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; A0A3B3HI74; -.
DR Ensembl; ENSORLT00000043114.1; ENSORLP00000031631.1; ENSORLG00000016314.3.
DR GeneTree; ENSGT00940000156120; -.
DR OrthoDB; 5482573at2759; -.
DR Proteomes; UP000001038; Chromosome 23.
DR Bgee; ENSORLG00000016314; Expressed in heart and 14 other cell types or tissues.
DR GO; GO:0019208; F:phosphatase regulator activity; IEA:InterPro.
DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd21944; IPD_MYPT1; 1.
DR Gene3D; 6.10.140.390; -; 1.
DR Gene3D; 6.10.250.1820; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR017401; MYPT1/MYPT2/Mbs85.
DR InterPro; IPR031775; PRKG1_interact.
DR PANTHER; PTHR24179; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12; 1.
DR PANTHER; PTHR24179:SF20; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12A; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF15898; PRKG1_interact; 1.
DR PIRSF; PIRSF038141; PP1_12ABC_vert; 3.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT REPEAT 72..104
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 105..137
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 198..230
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 231..263
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1015..1118
FT /note="cGMP-dependent protein kinase interacting"
FT /evidence="ECO:0000259|Pfam:PF15898"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..473
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..531
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..783
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..855
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 857..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..932
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 962..976
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 977..1001
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1118 AA; 124329 MW; 56D0000EB63817B7 CRC64;
MKMADAKQKR NEQLKRWMGS ETDQEPPVFK KKKTKVKFDD GAVFLAACSS GDTEEVLRML
DRGADINYAN VDGLTALHQA CIDDNVDMVT FLVEHGASVN QPDNEGWIPL HAAASCGYLD
IAEYLISQGA SVGVVNSEGE TPLDIAEEEA MGELLKNEIN RQGVDIEAAR KEEERIMLRD
ARQWLNSGQI QDVRHAKSGG TALHVAAAKG YVEVLKLLIQ AGYDVNIKDY DGWTPLHAAA
HWGKDEACRI LVENLCDMDV VNKMGQTAFD VADEDILGYL EELQKKQTLL MSEKKDVKKS
PLIETTTTGD NNQSLKPLKS KETLLLEPEK SAPCIETLEP EKVDEEEEGK KDESSCSSEE
EEDEDSESET EPEKNKPSAV VSNSTAPTSA SITVSSPSSP TNQVTTPTSP AKKFDYIPPL
MPVAEPGCPA LWRQGLRKTG ISLVPKKPMV VQPAVKVSSK VEEDKKDESP ASWRLGLRKT
GSYGALAEIT ATKEAQREKD TAGVMRSASS PRLSSSLDNK EKEKEKDKGT RLAYVAPTIP
RRLASTSDID EKENRDSTPL IRSGSYTRRR WDDDLKNSEG SSSINRTSSY KRSTSHTLAL
GRSGSTRDVP AKSSSTSSLD PNTYSTKPWQ PPTTHYQSYN VYRSGSFDRR HVDLSSSTTS
SSSTSTATTA AATTTTTSSS SSSSVTSPTG HRSLLFSLGS SSTRTGSSSL TSRYWSEESA
EREKEKESAA IIPTINTGST TTSTTTSTAT STTTGTGIGS EKRRSYLTPV RDEESESQRK
ARSRQARQSR RSTQGVTLTD LQEAEKTIGR SRPPKTWEEE KEEKEKQDKE KQEEKKETET
KEDDYRSKYR SFEERYRPSS SLASAVSSVT TASSTSSSSP LSSSSGSLFR PNSLSGITSS
YSRSSREAEK EMDKKEDEKD GEDKSQPRSI RDRRRPREKR RSTGVSFWTQ DGDENDPDQQ
SDLEESSLKG ELQSDRLSRN ESTSSLDRND TLLSRSYGES RRPYSSRLDR DDSTDYKKLY
EQILAENEKL KAQLRDTDLE LKDLKLQLEK ATQRQERYAD RSQLEMEKRE RRALERKISE
MEEELKNLPQ MLPDLKADNQ RLKDENGALI RVISKLSK
//
