ID A0A3B3HKU7_ORYLA Unreviewed; 1123 AA.
AC A0A3B3HKU7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Potassium channel, subfamily T, member 1 {ECO:0008006|Google:ProtNLM};
GN Name=kcnt1a {ECO:0000313|Ensembl:ENSORLP00000032522.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000032522.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000032522.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000032522.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000032522.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000032522.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3B3HKU7; -.
DR Ensembl; ENSORLT00000039751.1; ENSORLP00000032522.1; ENSORLG00000005264.2.
DR GeneTree; ENSGT00940000156880; -.
DR Proteomes; UP000001038; Chromosome 12.
DR Bgee; ENSORLG00000005264; Expressed in brain and 7 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF43; POTASSIUM CHANNEL SUBFAMILY T MEMBER 1 ISOFORM X1; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 237..304
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 462..556
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT REGION 1008..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1008..1029
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1123 AA; 127832 MW; 33B38DB074D477DB CRC64;
MDPEIIIHTW ISPSVGTWRS EPFGSDAGQR VQVEFYVNEN TFKERLKLFF IKNQRSSLRI
RVFNFCLKLL TCLLYIIRVM TDNPGQGTSS SHIAVQQNSA NGNNKCVDCQ WNGSVQDREI
NWELIFWVDR KLPVWAIQVI VAIISFLETM LLMYLSYKGN IWEQIFQVSF LLEMINTVPF
IITIFWPSIR NIFIPVFLNC WLAKCALENM INDVHRAIQR TNSAMFNQVL ILICTLLCLV
FTGTCGIQHL ERAGKNLSLF NSFYFCIVTF STVGFGDVTP RIWPSQLLVV IMICVALVVL
PLQFEELIYL WMERQKSGGN YSRHRAQTEK HVVLCVSSLK IDLLMDFLNE FYAHPRLQDY
YVVILCPSEM DVQVRRVLQI PLWSQRVIYL QGSVLKDQDL MRAKMDDAEA CFILSSRNEV
DRMAADHQTI LRAWAVKDFA PNCPLYVQIL KPENKFHVKF ADHVVCEEEF KYAMLALNCV
CPATSTLVTL LVHTSRGREG QQSPEHWQRM YGCCSGNEVY HIRLCDSKFF GEYNGKSFTY
ASFHAHKKYG VCLIGIKREE NKSILLNPGP HHIMASTDTC YYINITKEEN SAFIFNQEER
KGRPAGGIYD GPSQLPVHSI IASMGTVAID LQNTSPPNIS GGKLVPPTVN GTGIRRPSIA
PVQEIADANS ILACDLLGDQ SEDDSVFTDE KGRSPTEYVK GYPLNSPYIG SSPTLCHLLA
EKAPFCCLRL DQGCRHNSFV DAKAYGFKNK LIIVSAETAG NGLYNFIVPL RAYYRPRREL
NPIVLLLDNP PDNHFLEAIC CFPMVYYMAG TIDNLDSLLQ CGIIYADNLV VVDKESTMSA
EEDYMADAKT IVNVQTMFRL FPSLSIITEL THPSNMRFMQ FRAKDCYSLA LSKLEKKERD
KGSNLAFMFR LPFAAGRVFS ISMLDTLLYQ SFVKDYMILI TRLLLGLDTT PGSGFLCAMK
ITEGDLWIST YGRLFQKLCS SSAEIPIGIY RTESHIFSTS ESQVSVSVDD CEDTKDRADD
SRSNVQSDPP LRRKKSMQWA RRLSKKSVRW QGGSRDLNKD QAQRIAQQRL NLYRRSEREE
LSELVRNRMR HLGLPTSGYA EDLSNLTASD VMNRVNLGYL QGI
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