ID A0A3B3HLZ1_ORYLA Unreviewed; 1790 AA.
AC A0A3B3HLZ1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Kinesin family member 1Aa {ECO:0008006|Google:ProtNLM};
GN Name=kif1aa {ECO:0000313|Ensembl:ENSORLP00000032734.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000032734.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000032734.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000032734.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000032734.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000032734.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR STRING; 8090.ENSORLP00000032734; -.
DR Ensembl; ENSORLT00000040677.1; ENSORLP00000032734.1; ENSORLG00000001265.2.
DR GeneTree; ENSGT00940000156474; -.
DR InParanoid; A0A3B3HLZ1; -.
DR Proteomes; UP000001038; Chromosome 4.
DR Bgee; ENSORLG00000001265; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0008574; F:plus-end-directed microtubule motor activity; IBA:GO_Central.
DR GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IBA:GO_Central.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd01233; PH_KIFIA_KIFIB; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR049780; PH_KIFIA_KIFIB.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF2; KINESIN-LIKE PROTEIN KIF1A ISOFORM X1; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 5..355
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 530..585
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 1675..1773
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 872..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1632..1658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 444..471
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 641..690
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 872..895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 903..937
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 96..103
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1790 AA; 201827 MW; 8220B2614F1D0138 CRC64;
MAGASVKVAV RVRPFNSREI GKESKCIIQM TGNTTTISHP KQAKDVKSFN FDYSYWSHTS
PEDVNYASQM QVYKDIGEEM LLHAFEGYNV CIFAYGQTGA GKSYTMMGKQ DVKDQQGIIP
LLCEDLFRKI SDNTDNSMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLMGPYVED
LSKLAVTSYN DIQDLMDSGN KARTVAATNM NETSSRSHAV FNIIFTQKRH DAETDNTSEK
VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEMDS GPNKNKKKKK
AESFIPYRDS VLTWLLRENL GGNSRTAMVA ALSPADINYD ETLSTLRYAD RAKQIRCNAV
INEDPNNRLV RELKDEVSRL KDLLYAQGLG DIIETYRASD VDLETLKLTN AMTGMSPSPS
LSALSSRAGS IASLHDRIMF SPGSEEAIER LKETEKIIAE LNETWEEKLR KTEAIRMERE
ALLAEMGVAM REDGGTVGVF SPKKTPHLVN LNEDPLMSEC LLYYIKDGMT RVGRLDASKH
QDIGLSGHFI QDEHCTFTSS TGPTGETVVL EPCEGAETYV NGKRVTEPTV LRSGNRIILG
KSHVFRFNHP AQARAERERT PCAETPSEPV DWAFAQRELL EKQGIDMKQE MEQRLQELED
QYRREREEAN NLLEQQRLDY ESKLEALQKQ VDRCHPEASE EDEEAEEEVQ WTERERELAE
WSFRKWKGYQ FTSLRDLLWG NAIFLKEANA ISVELKKKVQ FQFVLLTDTL YSPLPPDFLP
PEATQDREKM HFPRTIVAVE VQDQKNGATH YWTLEKLRQR LDLMREMYDR AADVPNTATE
ECENAMTGGD PFYDRFPWFR LVGRNPIFNT CMSERMSDPT PSPTLSTSEI TELATSQREG
RGEEEEEMED LDDDIFLDDP SSELVAEDDD DDDDDDGGAL CRGSSEGQDP FYDRSPLFSV
VGRAFVYLSN LLYPVPLVHR VAIVSEKGEV KGFLRVAVQA ISADEEAPDY GSGVRQSGTA
KISFEDQQYE RFQSESCSAG LSRTGISQEE LRIVEGEGQN AEVGPSADEV NNNTAGTDEL
ENPLKACLDG ASEATLEHLR IGNVFTFRVT VLQASSISAE YADIFCQFNF IHRHDEAFST
EPLKNTGRGP PLGFYHVQNI AVEVTKSFVD YIKTQPVVFE VFGHYQKQPF LPLCKDVMSP
LRPCRRQFPQ VMPLSKPVPA TKLKAMARPQ AGPCHCKYDL MVFFEICELE ATGEYIPAVV
DHRGGMPCHG TFLLHQGLQR RVAVTIVHES GGDVEWRDVR ELVVGRLRNT PEADETIMDP
NILSLNILSA GYVKPLLDDR QFLDSDMPRT FYRFEAAWDS SMHNSLLLNR VTPYGEKIYM
TLSAYLEMEN CTQPAVLTKD ICMVFYSRDT KLSATRSIRN LFGTGSLRAA DGNRVTGVYE
VSLCYLADAG SPGMQRRRRR VLDTSVAYVR GEENLAGWRP RSDSLILDHQ WELEKLSLLQ
DVEKTKHYLL LREKLESTLL MGQESLQCGT SEDLCESPKP CEVDQEASCS SEITTERQRE
LAAKCLRLLT HSFNREYSHV CVSASESKIS EMSVTMLKDS PSTYALNTIT PSSTCPSLVD
GSYITADLRL PRPRPRADTQ QEAAEAKAPV NGASDAKPAT RRFVPDIQEI RVSPIVSKKG
YLHFLEPNTN GWVKRFVTVR RPYVYIYNSE RDTVERAILN LSSAQVEYSE DQQAMLKTPN
TFAVCTEHRG ILLQAANEKE MHDWLYAFNP LLAGTIRSKL SRRRAGQMKM
//
