ID A0A3B3HM51_ORYLA Unreviewed; 511 AA.
AC A0A3B3HM51;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Nectin cell adhesion molecule 1 {ECO:0000313|Ensembl:ENSORLP00000032789.1};
GN Name=NECTIN1 {ECO:0000313|Ensembl:ENSORLP00000032789.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000032789.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000032789.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000032789.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000032789.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000032789.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nectin family.
CC {ECO:0000256|ARBA:ARBA00007810}.
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DR RefSeq; XP_011480594.1; XM_011482292.1.
DR AlphaFoldDB; A0A3B3HM51; -.
DR Ensembl; ENSORLT00000044913.1; ENSORLP00000032789.1; ENSORLG00000002527.2.
DR GeneID; 101170036; -.
DR CTD; 557665; -.
DR GeneTree; ENSGT00940000156933; -.
DR OrthoDB; 5358399at2759; -.
DR Proteomes; UP000001038; Chromosome 13.
DR Bgee; ENSORLG00000002527; Expressed in pharyngeal gill and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR23277:SF69; NECTIN-1; 1.
DR PANTHER; PTHR23277; NECTIN-RELATED; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..511
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017229791"
FT TRANSMEM 363..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..139
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 144..239
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 244..331
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 409..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..476
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 511 AA; 56643 MW; 674ECEA15EDFD809 CRC64;
MARCVGLWAL LLALHVQAGD GQVVQMDSVK SGFVGSQVEL RCVFVNSNPP VKVSQVTWQK
LLNGTKQNVA IVNPVLGVSV LSPFRERVSF KQATVRHQMS SLEDTTIVFS NLQLSDEAAY
ICEYTTFPAG NRENMVNLTV YAQPQTRMSL TSTTIVAKTP RRKMTVATCM AANGKPPSVI
KWETRIKGDA TYQETRNQNG TVTVRSNYQV TPSRETHKQK LTCIVTYRGE RITESVVLNV
QYEPEVKIEG FDGNWYLNRQ TVQLTCRADA NPPVTIYQWK LLNGSLPSNV EIKNNTLFFK
GPVTYDLAGT YVCDATNAIG TRTGVVDVNI TDFPSPDRGI VQSTDFPTNP PNNHGIQQEQ
HSAGVVIGGA VGGVALLGVA AVLLFIFLRR RQRTFKGDYN TKKHAFGNGY SKAGGLPAHP
SKPKNLPYPD DSDDEKKPTQ IGSTGGFEPS DRNFDTESED LKRPYFTVDE GESREYDERT
LGFQYDPEPE IVDDMISQTD GSVISKKEWY V
//
