ID A0A3B3HMY1_ORYLA Unreviewed; 1286 AA.
AC A0A3B3HMY1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Alpha-2-macroglobulin-like 1 {ECO:0008006|Google:ProtNLM};
GN Name=LOC111948476 {ECO:0000313|Ensembl:ENSORLP00000033242.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000033242.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000033242.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000033242.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000033242.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000033242.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
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DR STRING; 8090.ENSORLP00000033242; -.
DR Ensembl; ENSORLT00000037305.1; ENSORLP00000033242.1; ENSORLG00000030198.1.
DR GeneTree; ENSGT00940000166660; -.
DR InParanoid; A0A3B3HMY1; -.
DR Proteomes; UP000001038; Chromosome 2.
DR Bgee; ENSORLG00000030198; Expressed in gastrula and 6 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF160; ALPHA-2-MACROGLOBULIN-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 345..486
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 594..683
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1192..1280
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1286 AA; 142534 MW; 4F6607B571582C1D CRC64;
MFLIPSSGYR TYLVTVSSHL TAGNKEILCA LIKTPTEPAS LTITLDVDSS STKIGQLSFK
TEIYRCFQFL VLSSTTVASI SVKIQGKMDS LYQETKVLIE PPAFVHIVQT EKPIYKPGQT
VQFRIVSMDT NFIPVNRMDP NSNRIAQWMD KSIDGGILDL SHSTIPEAAQ GIYVITAETD
KGETVSHNFE IKEYVLPKFE VTVNLPTVIT ILDDEVTLKI CGKYTYGKPV LGSVRADIYL
QIIMSKQSLF LLQSFFLFLQ IKVTGADGSP IANQAVYLYV VDSLEFTLYT DQKGIAVFSL
DTSSWSESVS LSVSGDLLQL LVAFCTKRVS CWTNNPIGRY KRSILNVQPL KNIFCCFIKK
NKLNMFCIKL FKDCLCNNCI IVLGELRYTA VFLNVSPVNK GTIKIPLTNV IDLAPIAQVV
VYTIVSSGEV VADSRDFPIQ LCLNNKVSLK FSAVQELPGA KTTLTLRAQP SSLCSVRAID
QSVLLLKSEE ELTVDYVYNQ LPIKKMWEYD YQVEDDSFNP CFPRPWPRPI ALEPELLPRE
LRDTVSHIFP LYEGDDVYTI FKVKSFTFLI NFCMAAPAPE GEKTETIRTY FPETWIWDLV
SVGSSGSTSL VKTVPDTITK WTAGAFCVSP AGFGVAPNVR LTAFQPFFVS LTLPYSVVRG
EVFTLKATVF NYLPKCIMVK ATLVKSDQFT FKNCDGCVYS SVCLCAEESK TFSWIVTPTA
LGDVTLKVSA EAEKSNKKCG TEVVTVPTLG QVDTVITTLL VEVKGPVSKK ISLELPEDFV
NGSEGASVSV VGDLMGRAMK NLDKLLAMPY GCGEQNMLLF APNIFILDYL KSTGQLKEST
QKMAVGYLES GYQRELNYKR DDGSYSAFGM GDPSGNTWLT TFVMKSFNAA KQYIFVDQKY
IQDARTWLSG LQKPDGCIQS LGKLFHNGMK GGVSDDVSLT AYVAAAMLEL DGNATNPVVQ
NCLKCLRTAV SGKITNLYTV ALLSYTFTLA GDQDMRSKLI TLLDQKSINE GGTRHWKRDG
ASETDLDSVE VEMTSYVLLA LLSGPSLPGF GLDYAAGIVR WLAQQQNPFG GFSSTQDTVV
ALQALAKYAT ATFSPEGSTT VTVTSVGGLN KRFTVNKDNR LLYQEEKLTQ IPGEYTIKAE
GQSCVLAQIS LFYNIPPPSD FSAFEISTNT RGQCDIPRPE FTLFVEGRRE ETNMVVINIK
LLSGYILQDN SLKMLKENRL VKRVDVEEGY INIYLDGVRS FEKETFNVIL EEDQQVGNLK
PAVVKVYDYY QTSDEAVTDY TSPCNK
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