ID A0A3B3HQ34_ORYLA Unreviewed; 995 AA.
AC A0A3B3HQ34;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Nuclear transcription factor, X-box binding 1 {ECO:0000313|Ensembl:ENSORLP00000033897.1};
GN Name=NFX1 {ECO:0000313|Ensembl:ENSORLP00000033897.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000033897.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000033897.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000033897.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000033897.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000033897.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NFX1 family.
CC {ECO:0000256|ARBA:ARBA00007269}.
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DR AlphaFoldDB; A0A3B3HQ34; -.
DR Ensembl; ENSORLT00000038099.1; ENSORLP00000033897.1; ENSORLG00000026662.1.
DR GeneTree; ENSGT00940000156325; -.
DR Proteomes; UP000001038; Chromosome 20.
DR Bgee; ENSORLG00000026662; Expressed in ovary and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06008; NF-X1-zinc-finger; 6.
DR CDD; cd02643; R3H_NF-X1; 1.
DR CDD; cd16696; RING-CH-C4HC3_NFX1; 1.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR034078; NFX1_fam.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR034076; R3H_NF-X1.
DR InterPro; IPR000967; Znf_NFX1.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR12360; NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1; 1.
DR PANTHER; PTHR12360:SF12; TRANSCRIPTIONAL REPRESSOR NF-X1; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF01422; zf-NF-X1; 8.
DR SMART; SM00393; R3H; 1.
DR SMART; SM00438; ZnF_NFX; 9.
DR SUPFAM; SSF82708; R3H domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 228..285
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 231..283
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 868..936
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT REGION 1..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..148
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 995 AA; 110385 MW; 20F9EC6E4E99B082 CRC64;
MAEGSSDPQN FNQDGSSLQK THQQRSRRGR PRNNAHNPPF RGEDTAQRRG RGRGRREGDR
GLNGNPDASG SWWQRSGHEF GQHGSGSRNV EQRRAEQRER GDHFKAADQR HGTKGETTER
TQESKSGPKR HYHETQKKEV EVKRRQGPIK PPKPPSQEID GRERGANARL DSDQSRPAQD
SRGPPPPAKG GKRFNQRSHK PGRQSWEQVP KSKETQTGCL IEQLTEENYE CMVCCDVIRV
MAPVWSCQSC FHVFHLNCIK KWARSPASQA DDSTEGWRCP ACQNVALKSP ASYTCFCGKV
TNPEWRRSEI PHSCGDMCGK RRGGDCNHPC NILCHPGPCP QCPAFVTKSC ICGKTSQPMR
CGQAAVLRCD RVCAALLNCA VHTCMQLCHA GPCEPCQRQI KQVCHCGVAT REVPCGTDKD
GSVGSGHYSC RNTCGKKLSC DAHECQEVCH PGACQPCPRS PKLVKTCPCG QTALTKLLEL
GYAERKICSD PIPSCGKTCY KPLACGSSDT IHLCQNLCHE GSCGPCSLTS TVRCRCGFKT
KDVPCSLIQK EEELIFTCDR RCNKKRLCGR HKCGELCCVN VEHKCLLICG YKLNCGLHRC
QEPCHRGNCE PCWQSSFDEL SCHCGLTVLY PPIPCGTKPP ECKNPCTRRH ECNHPVFHNC
HSEDKCPPCT YLTQKWCMGK HEQRSNIPCH LQDISCGLMC NKPLPCEMHR CKRLCHRGEC
LPDGGCCQQP CALPRPDCGH PCSAPCHEGS SCPRTTCTAK VALQCDCGRR KDTVACADAA
TSYQRYAAIA MASKLSDMQL GDSMDMGPLL TKKEAKQTRL DCDEECATLE RNRRLAEALQ
IDATSDPFNT RSTSVYSSSL KEDARKDLKF VTEVEEEMRS LVELANKGKQ PKRSHCFPAM
NREHRKIIHE LAEVYGVESA SYDSEPKRNV IITAHKGKSA CPNSSLTAVI ERETAARAPP
PIAHIKQQSS RAAGGSAWSK MLKEEPAIDY FDVQD
//
