ID A0A3B3HSM1_ORYLA Unreviewed; 1569 AA.
AC A0A3B3HSM1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Shroom family member 1 {ECO:0008006|Google:ProtNLM};
GN Name=shroom1 {ECO:0000313|Ensembl:ENSORLP00000034745.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000034745.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000034745.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000034745.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000034745.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000034745.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the shroom family.
CC {ECO:0000256|ARBA:ARBA00006469}.
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DR RefSeq; XP_004076171.1; XM_004076123.2.
DR RefSeq; XP_011481485.1; XM_011483183.1.
DR RefSeq; XP_011481486.1; XM_011483184.1.
DR STRING; 8090.ENSORLP00000034745; -.
DR Ensembl; ENSORLT00000038773.1; ENSORLP00000034745.1; ENSORLG00000030255.1.
DR GeneID; 101169477; -.
DR KEGG; ola:101169477; -.
DR CTD; 134549; -.
DR GeneTree; ENSGT00940000160656; -.
DR InParanoid; A0A3B3HSM1; -.
DR OrthoDB; 4120529at2759; -.
DR Proteomes; UP000001038; Chromosome 14.
DR Bgee; ENSORLG00000030255; Expressed in intestine and 14 other cell types or tissues.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0043296; C:apical junction complex; IBA:GO_Central.
DR GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR Gene3D; 6.10.250.3120; -; 1.
DR InterPro; IPR014800; ASD1_dom.
DR InterPro; IPR014799; ASD2_dom.
DR InterPro; IPR027685; Shroom_fam.
DR PANTHER; PTHR15012; APICAL PROTEIN/SHROOM-RELATED; 1.
DR PANTHER; PTHR15012:SF37; PROTEIN SHROOM1; 1.
DR Pfam; PF08688; ASD1; 1.
DR Pfam; PF08687; ASD2; 1.
DR PROSITE; PS51306; ASD1; 1.
DR PROSITE; PS51307; ASD2; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00637};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 616..741
FT /note="ASD1"
FT /evidence="ECO:0000259|PROSITE:PS51306"
FT DOMAIN 1301..1568
FT /note="ASD2"
FT /evidence="ECO:0000259|PROSITE:PS51307"
FT REGION 39..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 635..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 822..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 895..948
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 970..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1147..1225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1268..1296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1532..1566
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 48..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..531
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..693
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..945
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 996..1019
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1035..1058
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1065..1112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1147..1169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1182..1200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1569 AA; 175556 MW; 6081705C9828A5AC CRC64;
MDSYSLHFDR MSNVDLHPLS LPVSRLSPAK SSSSIIEQLA HHQHGKGDSA YSSFSGGSTA
PDYPSPFLQD ELQPNSFSHY AELGCVKSLY RPAQILHSES KTMDQLYRSV EAISQQYHNS
TNINHQSENT DNNLHGNNKT LSTQHAHSRN PSQGGQPHSP PPPIPARLDS YIATKNLENS
RVHHSTELQP QQPKPQQNSR SHSQLIPCGL PPKSETANQD NNSPSFNGDP VWRAVKQEQP
QAQNPPSHQS HLQYHKDTRM TPEDLFITDN KALTEQQRPA NILSKSPPRR NCQPNHLPPR
ESLSSDGYDR ENHKKHSSYS GTYRRRAHSA QDQIVLDPTR GASPWNAGQN LISGSIQHKG
QFYFVTGVCK MSESGLRMHS ASTSGAEDGR DISVLLERRQ HRDKERSHST LDSMFRPFQE
SSCSSIPEKR EVFTPVSRKK DLMSKISDQE NPRQTHLSQS PPIFDSLEDM DFMHSQEIGR
HTLDSPIFYC GPDRKGPPLS AAPQKEFSTL FSKDQSNHNN REDPAKKEKE QTLCDAVSEK
INKDTTPLLY HLTGANLSVL QPKNESGFST KDHGDVGVND GRPPQHDAVM TDRGGVSSVA
CNTLDDSFKK YYKEKLKDAQ RKVLRETSFT RRDLQLSLPN QARLKPEQRP TSIHSFSSSQ
DSETSTDTLT PSVTSEETER GSIKEKASEN LKMTERDFEK VNGRPAHVAQ PQVARIGGRK
RLTPEQKKIC YSEPEKLNQL DGGPQHAVCR SFGNESDSPF TAEYEEEERV HQGDQGLVAS
RRKMFETRGR AMSVSGASQT NLKHFRHKAL VEYMERKTGH IVTEPQQPMA QLPSQPRQRH
SLGEKPSDWG VRSTPGNHEG RNAKKHRPHS AGRILDCPQS SMRYAQFLPA QSCSGQYAGR
QNPFRQRQSR GSAQAKSASA ESLLDQQESA GLCRNRSTST PHAFQAHEYS EDLLTVDSME
TRSFQKNAVE ESLVKPLSGG PLPVRVAAQR GKSMEELGTS KMTQPCAMSK SSEHLDQLQK
ISNGPGGPGR DEAGASRGGH GKETQWNERG RKNQAVKEPE FICQKNPQEQ IQNQTQKQPL
SQQSSVEDSI AEEKSSSRSC SPPSTSSSHF RAHSACLGPH GPLSDGLGSG KESILHFRGL
DSDMKIKSIV SQTNPPCETP SCSSKEKTSS GLSRAEKEQN VDDSSSNLQP PESNHEVPLS
CGITTEPFLW NLPPNEESSE EAQTPLEDSV FDEFPSSDLM KQTSEAFVPV CTPVSDADLD
QEAEEQKLPG MEAKAVGEKT EERGTPEGET VENPNEKPQW EELVEAVVKA DQSLARVLFP
LANRKTALML MEQVMSEDTL LMEEHYKRKQ EQRGTAESAV MVEGPEKSAF DSASDIQESR
PADVLCKDKI SEMKHLLVSY IEAHLRSLEE RRCALQMEVQ ENAARGKVLE VLVQERCQPV
EQERYNLFIG DLERVMNLLL CLSARLARVQ NALSNVDENT DAEEKECLDS RHRLLCKQRD
DAKDLKDNLD RRENLVSTFL SRQLSEEQVQ DYRRFVQTKA SLLIRLKDLE EKQRLGEEQL
EALSSRLKP
//
