ID A0A3B3HTD2_ORYLA Unreviewed; 1349 AA.
AC A0A3B3HTD2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Regulatory associated protein of MTOR complex 1 {ECO:0000313|Ensembl:ENSORLP00000034588.1};
GN Name=RPTOR {ECO:0000313|Ensembl:ENSORLP00000034588.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000034588.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000034588.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000034588.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000034588.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000034588.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat RAPTOR family.
CC {ECO:0000256|ARBA:ARBA00009257}.
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DR Ensembl; ENSORLT00000029739.1; ENSORLP00000034588.1; ENSORLG00000001734.2.
DR GeneTree; ENSGT00640000091541; -.
DR Proteomes; UP000001038; Chromosome 1.
DR Bgee; ENSORLG00000001734; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0031931; C:TORC1 complex; IEA:InterPro.
DR GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR004083; Raptor.
DR InterPro; IPR029347; Raptor_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR12848; REGULATORY-ASSOCIATED PROTEIN OF MTOR; 1.
DR PANTHER; PTHR12848:SF16; REGULATORY-ASSOCIATED PROTEIN OF MTOR; 1.
DR Pfam; PF02985; HEAT; 2.
DR Pfam; PF14538; Raptor_N; 1.
DR Pfam; PF00400; WD40; 1.
DR PRINTS; PR01547; YEAST176DUF.
DR SMART; SM01302; Raptor_N; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 56..209
FT /note="Raptor N-terminal CASPase-like"
FT /evidence="ECO:0000259|SMART:SM01302"
FT REGION 694..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 748..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 855..945
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..708
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..772
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 855..897
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..945
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1349 AA; 151259 MW; 80872698C9B72F8C CRC64;
MKMDSDLLHS PAVGLAEEEE ADMNDWKLPL TFMKKRHLEK IEGSKALAQS WRMKDRMKTV
SVALVLCLNV GVDPPDVVKT SPCARLECWI DPLSMSPQKA LETIGANLQK QYENWQPRAR
YKQSLDPTVD EVKKLCTSLR RNAKEERVLF HYNGHGVPRP TVNGEIWVFN KNYTQYIPLS
IYDLQTWMGS PSIFVYDCSN AGIIVKSFKQ FALQREQELE VAAINPSHPL AQMPLPPSMK
NCIQLAACEA SELLPMNPDL PADLFTSCLT TPITIALRWF CMQKSAKLVP GVTLDLIEKI
PGRLNDRRTP LGELNWIFTA ITDTIAWNVL PRDLFQKLFR QDLLVASLFR NFLLAERIMR
SYNCTPVSSP RLPPTYMHAM WQAWDLAVDI CLSQLPTIME GTAFRPSEFF TQQLTAFEVW
LTMGVENRNP PEQLPIVLQV LLSQVHRLRA LELLGQFLDL GPWAVSLALS VGIFPYVLKL
LQSSARELRP LLVFIWAKIL AVDSSCQADL VKDNGHKYFL SVLADNYMPA EHRTMAVFIL
AVIVNNYSTG QEACLQGNLI ANCLEQLSDP HPLLRQWVAI CLGRIWQNFD PARWCGVRDS
AHEKLYTLLS DPIPEVRCAA VFALGTFVGN SGERTDHSTT IDHNVAMMLA QLINDGSPVV
RKELVVALSH LVVQYESNFC TVALQFIEEE KNYSVPSPAN TTEPGNLTPV RDSPAIPRLR
SVNSYTNIRA VTTARNLNKS LQNLNLNEEG GPAAFSPGNL STSSSASSTL GSPDNDEYIL
SFETIDKMRR VSSYSSLNSL IGVSFNSVYT QIWRVLLHLA ADPFPEVSDL AMKVLNSIAY
KATMNARPQR ILDSASLTKS APASPTSKGT LIHQAGGSPP MPSTSSSSLT NDVPKPPNRE
QPATRPPYTP TLGGQAPHSH QFPRTRKMFD KGPEQGAEDG DEPVGHRNYV SLSLQTGLCD
WSAKYFAQPV TKIPEEHDLE SQVRMERQWR FLRNARVRRQ SRVITQRGIS RLDDQIFINR
NPGVPSVVKF HPFNTCIAVA DKDSICFWDW EKGERLDYFY NGNPRYTRIT AMQYLNGHDC
SLLLTATDDG ALRIWKNFAD QKNPEMVTAW QGLSDMLPTT RGLARRVSIY LDRSKQGGAG
MVVDWEQETG LLMTSGDVRI IRIWDTDREM KVQDIPTGAD SCVTSLSCDS HRSLVVAGLG
DGSVRVFDRR MGPNECRVMT YREHGAWVVK AHLQKEADGN IISVSVNGDV RFFEPRTPDS
INVLQTVKGL TALDIHPQAN LFACGSMNQF IAVYNSNGDV ISNIKYYDGF MGQRIGAISC
LAFHPYWPHL AVGSNDYYMS IYSAEKRLR
//
